Amplification of immunity by engineering chicken MDA5 combined with the C terminal domain (CTD) of RIG-I

Transcriptomic Analysis of the Chicken MDA5 Response Genes

(2020) Shiman Yu et al.   Genes

Targeted Knockout of MDA5 and TLR3 in the DF-1 Chicken Fibroblast Cell Line Impairs Innate Immune Response Against RNA Ligands

(2020) Su Bin Lee et al.   Frontiers in Immunology

Evolutionary selection on MDA5 and LGP2 in the chicken preserves antiviral competence in the absence of RIG-I

(2019) Ling Xu et al.   Journal of Genetics and Genomics

Susceptibility of Chickens to Low Pathogenic Avian Influenza (LPAI) Viruses of Wild Bird– and Poultry–Associated Subtypes

(2019) Bergervoet et al.   Viruses-Basel

Overexpression of Chicken IRF7 Increased Viral Replication and Programmed Cell Death to the Avian Influenza Virus Infection Through TGF-Beta/FoxO Signaling Axis in DF-1

(2018) Tae Hyun Kim et al.   Frontiers in Genetics

Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis

(2018) Qin Yu et al.   MOLECULAR CELL

Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5

(2016) Emiko Uchikawa et al.   MOLECULAR CELL

RIG-I in RNA virus recognition

(2015) Alison M. Kell et al.   VIROLOGY

Duck RIG-I CARD Domain Induces the Chicken IFN-βby Activating NF-κB

(2015) Yang Chen et al.   Biomed Research International

Mechanisms of RIG-I-Like Receptor Activation and Manipulation by Viral Pathogens

(2014) M. U. Gack   JOURNAL OF VIROLOGY

A novel virus-inducible enhancer of the interferon-β gene with tightly linked promoter and enhancer activities

(2014) A. Raja Banerjee et al.   NUCLEIC ACIDS RESEARCH

In Vivo Ligands of MDA5 and RIG-I in Measles Virus-Infected Cells

(2014) Simon Runge et al.   PLoS Pathogens

Parts, assembly and operation of the RIG-I family of motors

(2013) David C Rawling et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Chicken MDA5 Senses Short Double-Stranded RNA with Implications for Antiviral Response against Avian Influenza Viruses in Chicken

(2013) Tsuyoshi Hayashi et al.   Journal of Innate Immunity

LGP2 Plays a Critical Role in Sensitizing mda-5 to Activation by Double-Stranded RNA

(2013) Kay S. Childs et al.   PLoS One

Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5

(2012) Bin Wu et al.   CELL

Goose RIG-I functions in innate immunity against Newcastle disease virus infections

(2012) Yingjie Sun et al.   MOLECULAR IMMUNOLOGY

A FOXO3–IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses

(2012) Vladimir Litvak et al.   NATURE

MDA5 Detects the Double-Stranded RNA Replicative Form in Picornavirus-Infected Cells

(2012) Qian Feng et al.   Cell Reports

Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA

(2011) Eva Kowalinski et al.   CELL

Activation of RIG-I-like receptor signal transduction

(2011) Annie M. Bruns et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter

(2011) S Mehdi Belgnaoui et al.   CURRENT OPINION IN IMMUNOLOGY

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

Chicken Cells Sense Influenza A Virus Infection through MDA5 and CARDIF Signaling Involving LGP2

(2011) M. Liniger et al.   JOURNAL OF VIROLOGY

From unwinding to clamping — the DEAD box RNA helicase family

(2011) Patrick Linder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition

(2011) A. Peisley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of RIG-I with innate immunity of ducks to influenza

(2010) M. R. W. Barber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

(2010) T. Satoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5

(2009) Xiaojun Li et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Origin and evolution of the RIG-I like RNA helicase gene family

(2009) Jun Zou et al.   BMC EVOLUTIONARY BIOLOGY

Solution Structures of Cytosolic RNA Sensor MDA5 and LGP2 C-terminal Domains

(2009) Kiyohiro Takahasi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA

(2009) Diana A. Pippig et al.   NUCLEIC ACIDS RESEARCH

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The C-Terminal Regulatory Domain Is the RNA 5′-Triphosphate Sensor of RIG-I

(2008) Sheng Cui et al.   MOLECULAR CELL