Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis

Title

Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis

Authors

Keywords

RIG-I-like receptor, RLR, nucleic acid sensing, innate immune pattern recognition, DExD/H-box RNA helicase, superfamily 2 helicases, SF2 helicases, cryoelectron microscopy, cryo-EM, helical reconstruction, ATPase, Aicardi-Goutières syndrome, AGS, Singleton-Merten syndrome, SMS

Journal

MOLECULAR CELL

Volume 72, Issue 6, Pages 999-1012.e6

Publisher

Elsevier BV

Online

2018-11-16

DOI

10.1016/j.molcel.2018.10.012