Targeted Enrichment of Enzyme‐Instructed Assemblies in Cancer Cell Lysosomes Turns Immunologically Cold Tumors Hot

Self-Guiding Polymeric Prodrug Micelles with Two Aggregation-Induced Emission Photosensitizers for Enhanced Chemo-Photodynamic Therapy

(2021) Xiaoqing Yi et al.   ACS Nano

Supramolecular Self‐Assembly‐Facilitated Aggregation of Tumor‐Specific Transmembrane Receptors for Signaling Activation and Converting Immunologically Cold to Hot Tumors

(2021) Jun Li et al.   ADVANCED MATERIALS

Semiconducting polymer nano-PROTACs for activatable photo-immunometabolic cancer therapy

(2021) Chi Zhang et al.   Nature Communications

Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery

(2021) Lei Jiang et al.   Nature Communications

Identification and Single‐Cell Analysis of Viable Circulating Tumor Cells by a Mitochondrion‐Specific AIE Bioprobe

(2020) Bo Situ et al.   Advanced Science

Targeted crystallization of mixed-charge nanoparticles in lysosomes induces selective death of cancer cells

(2020) Magdalena Borkowska et al.   Nature Nanotechnology

Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti–PD-1/PD-L1 immunotherapy

(2020) Muhammad Zaeem Noman et al.   Science Advances

Bioinorganic hybrid bacteriophage for modulation of intestinal microbiota to remodel tumor-immune microenvironment against colorectal cancer

(2020) Xue Dong et al.   Science Advances

Supramolecular prodrug hydrogelator as an immune booster for checkpoint blocker–based immunotherapy

(2020) Feihu Wang et al.   Science Advances

Near-Infrared-Activated Lysosome Pathway Death Induced by ROS Generated from Layered Double Hydroxides-Copper Sulfide Nanocomposites

(2020) Chen-Guang Liu et al.   ACS Applied Materials & Interfaces

Multispectral Nanoparticle Tracking Analysis for the Real-Time and Label-Free Characterization of Amyloid-β Self-Assembly in vitro

(2020) Colman Moore et al.   ANALYTICAL CHEMISTRY

Enzymatically Formed Peptide Assemblies Sequestrate Proteins and Relocate Inhibitors to Selectively Kill Cancer Cells

(2020) Hongjian He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Autophagy as a decisive process for cell death

(2020) Seonghee Jung et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Enzymatic Noncovalent Synthesis

(2020) Hongjian He et al.   CHEMICAL REVIEWS

Advances in nanomaterial vaccine strategies to address infectious diseases impacting global health

(2020) Chelsea N. Fries et al.   Nature Nanotechnology

Endoplasmic reticulum targeted AIE bioprobe as a highly efficient inducer of immunogenic cell death

(2020) Jun Li et al.   Science China-Chemistry

Lysosomal quality control of cell fate: a novel therapeutic target for human diseases

(2020) Sheng-yu Zhu et al.   Cell Death & Disease

Directly observing intracellular nanoparticle formation with nanocomputed tomography

(2020) Miaomiao Zhang et al.   Science Advances

Targeting immunogenic cell death in cancer

(2020) Asma Ahmed et al.   Molecular Oncology

Bispyrene-Based Self-Assembled Nanomaterials: In Vivo Self-Assembly, Transformation, and Biomedical Effects

(2019) Ping-Ping He et al.   ACCOUNTS OF CHEMICAL RESEARCH

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

(2019) Jérôme Galon et al.   NATURE REVIEWS DRUG DISCOVERY

Turning “Cold” Into “Hot” Tumors—Opportunities and Challenges for Radio-Immunotherapy Against Primary and Metastatic Brain Cancers

(2019) Lisa Sevenich   Frontiers in Oncology

A Multifunctional Peptide-Conjugated AIEgen for Efficient and Sequential Targeted Gene Delivery into the Nucleus

(2019) Yong Cheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Assemblies of Peptides in Complex Environment and Their Applications

(2019) Bing Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Microenvironment-Induced In Situ Self-Assembly of Polymer-Peptide Conjugates That Attack Solid Tumors Deeply

(2019) Yong Cong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tumor Microenvironment-Activatable Prodrug Vesicles for Nanoenabled Cancer Chemoimmunotherapy Combining Immunogenic Cell Death Induction and CD47 Blockade

(2019) Fangyuan Zhou et al.   ADVANCED MATERIALS

Boosting Cancer Therapy with Organelle-Targeted Nanomaterials

(2019) peng gao et al.   ACS Applied Materials & Interfaces

Enzyme‐Instructed Self‐Assembly (EISA) and Hydrogelation of Peptides

(2019) Jie Gao et al.   ADVANCED MATERIALS

Manipulating the intramolecular motion of AIEgens for boosted biomedical applications

(2019) Hanlin Ou et al.   Science China-Chemistry

Key Role of Microtubule and Its Acetylation in a Zinc Oxide Nanoparticle–Mediated Lysosome–Autophagy System

(2019) Jia Liu et al.   Small

Supramolecular protein glue to boost enzyme activity

(2019) Yuna Shang et al.   Science China-Materials

Activatable NIR Fluorescence/MRI Bimodal Probes for in Vivo Imaging by Enzyme-Mediated Fluorogenic Reaction and Self-Assembly

(2019) Runqi Yan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineering nanoparticles to locally activate T cells in the tumor microenvironment

(2019) Dangge Wang et al.   Science Immunology

Ratiometric Fluorescent Strategy for Localizing Alkaline Phosphatase Activity in Mitochondria Based on the ESIPT Process

(2019) Peng Zhang et al.   ANALYTICAL CHEMISTRY

Massively Evoking Immunogenic Cell Death by Focused Mitochondrial Oxidative Stress using an AIE Luminogen with a Twisted Molecular Structure

(2019) Chao Chen et al.   ADVANCED MATERIALS

Lysosomes as dynamic regulators of cell and organismal homeostasis

(2019) Andrea Ballabio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Organelle-Targeting Gold Nanorods for Macromolecular Profiling of Subcellular Organelles and Enhanced Cancer Cell Killing

(2018) Yanting Shen et al.   ACS Applied Materials & Interfaces

Self-Assembled Peptide-Based Nanomaterials for Biomedical Imaging and Therapy

(2018) Guo-Bin Qi et al.   ADVANCED MATERIALS

Nanoparticle-mediated Immunogenic Cell Death Enables and Potentiates Cancer Immunotherapy

(2018) Xiaopin Duan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Minimalistic peptide supramolecular co-assembly: expanding the conformational space for nanotechnology

(2018) Pandeeswar Makam et al.   CHEMICAL SOCIETY REVIEWS

Peptide-based nanoprobes for molecular imaging and disease diagnostics

(2018) Pengcheng Zhang et al.   CHEMICAL SOCIETY REVIEWS

Enzymatic Assemblies Disrupt Membrane and Target Endoplasmic Reticulum (ER) for Selective Cancer Cell Death

(2018) Zhaoqianqi Feng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Controlled Tuning of the Properties in Optoelectronic Self-Sorted Gels

(2018) Emily R. Cross et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Functionalized chitosan with self-assembly induced and subcellular localization-dependent fluorescence ‘switch on’ property

(2018) Kuheli Mandal et al.   NEW JOURNAL OF CHEMISTRY

In situ formed reactive oxygen species–responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy

(2018) Chao Wang et al.   Science Translational Medicine

Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap

(2018) Wantong Song et al.   Nature Communications

Enzyme-instructed self-assembly leads to the activation of optical properties for selective fluorescence detection and photodynamic ablation of cancer cells

(2018) Shenglu Ji et al.   Journal of Materials Chemistry B

Combined local immunostimulatory radioisotope therapy and systemic immune checkpoint blockade imparts potent antitumour responses

(2018) Yu Chao et al.   Nature Biomedical Engineering

Controlling Supramolecular Chirality in Multicomponent Self-Assembled Systems

(2018) Pengyao Xing et al.   ACCOUNTS OF CHEMICAL RESEARCH

Binary Cooperative Prodrug Nanoparticles Improve Immunotherapy by Synergistically Modulating Immune Tumor Microenvironment

(2018) Bing Feng et al.   ADVANCED MATERIALS

Enzyme-Instructed Supramolecular Self-Assembly with Anticancer Activity

(2018) Qingxin Yao et al.   ADVANCED MATERIALS

The lysosome as a cellular centre for signalling, metabolism and quality control

(2018) Rosalie E. Lawrence et al.   NATURE CELL BIOLOGY

Polymeric peptide pigments with sequence-encoded properties

(2017) Ayala Lampel et al.   SCIENCE

AIEgen-based theranostic system: targeted imaging of cancer cells and adjuvant amplification of antitumor efficacy of paclitaxel

(2017) Chao Chen et al.   Chemical Science

Intracellular construction of topology-controlled polypeptide nanostructures with diverse biological functions

(2017) Li-Li Li et al.   Nature Communications

In situ activation of platelets with checkpoint inhibitors for post-surgical cancer immunotherapy

(2017) Chao Wang et al.   Nature Biomedical Engineering

Integrating Enzymatic Self-Assembly and Mitochondria Targeting for Selectively Killing Cancer Cells without Acquired Drug Resistance

(2016) Huaimin Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cell Environment-Differentiated Self-Assembly of Nanofibers

(2016) Zhen Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tuning Cellular Uptake of Molecular Probes by Rational Design of Their Assembly into Supramolecular Nanoprobes

(2016) Lye Lin Lock et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enzyme-Instructed Self-Assembly of Small d-Peptides as a Multiple-Step Process for Selectively Killing Cancer Cells

(2016) Jie Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy

(2016) Chunbai He et al.   Nature Communications

In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics

(2016) Xiangzhao Ai et al.   Nature Communications

Photosensitizer-Loaded Branched Polyethylenimine-PEGylated Ceria Nanoparticles for Imaging-Guided Synchronous Photochemotherapy

(2015) Zhang-You Yang et al.   ACS Applied Materials & Interfaces

Real-time monitoring of the mitophagy process by a photostable fluorescent mitochondrion-specific bioprobe with AIE characteristics

(2015) Weijie Zhang et al.   CHEMICAL COMMUNICATIONS

A multiphase transitioning peptide hydrogel for suturing ultrasmall vessels

(2015) Daniel J. Smith et al.   Nature Nanotechnology

Transient assembly of active materials fueled by a chemical reaction

(2015) J. Boekhoven et al.   SCIENCE

25th Anniversary Article: Supramolecular Materials for Regenerative Medicine

(2014) Job Boekhoven et al.   ADVANCED MATERIALS

Evaluation of acridine orange, LysoTracker Red, and quinacrine as fluorescent probes for long-term tracking of acidic vesicles

(2014) Agnieszka Pierzyńska-Mach et al.   CYTOMETRY PART A

Imaging of MMP Activity in Postischemic Cardiac Remodeling Using Radiolabeled MMP-2/9 Activatable Peptide Probes

(2014) Sander M.J. van Duijnhoven et al.   MOLECULAR PHARMACEUTICS

Installing logic-gate responses to a variety of biological substances in supramolecular hydrogel–enzyme hybrids

(2014) Masato Ikeda et al.   Nature Chemistry

Enzyme-triggered supramolecular self-assembly of platinum prodrug with enhanced tumor-selective accumulation and reduced systemic toxicity

(2014) Huan Liu et al.   Journal of Materials Chemistry B

Spatiotemporally controlled induction of autophagy-mediated lysosome turnover

(2013) Yu-Hsien Hung et al.   Nature Communications

Coassembly of Enantiomeric Amphipathic Peptides into Amyloid-Inspired Rippled β-Sheet Fibrils

(2012) Ria J. Swanekamp et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A biocompatible condensation reaction for controlled assembly of nanostructures in living cells

(2009) Gaolin Liang et al.   Nature Chemistry

Lysosomal membrane permeabilization in cell death

(2008) P Boya et al.   ONCOGENE