Supramolecular Self‐Assembly‐Facilitated Aggregation of Tumor‐Specific Transmembrane Receptors for Signaling Activation and Converting Immunologically Cold to Hot Tumors

Transformable peptide nanoparticles arrest HER2 signalling and cause cancer cell death in vivo

(2020) Lu Zhang et al.   Nature Nanotechnology

Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology

(2020) Isaure Vanmeerbeek et al.   OncoImmunology

Immunogenic cell death in colon cancer prevention and therapy

(2020) Hang Ruan et al.   MOLECULAR CARCINOGENESIS

Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti–PD-1/PD-L1 immunotherapy

(2020) Muhammad Zaeem Noman et al.   Science Advances

Bioinorganic hybrid bacteriophage for modulation of intestinal microbiota to remodel tumor-immune microenvironment against colorectal cancer

(2020) Xue Dong et al.   Science Advances

Supramolecular prodrug hydrogelator as an immune booster for checkpoint blocker–based immunotherapy

(2020) Feihu Wang et al.   Science Advances

Collagen-binding IL-12 enhances tumour inflammation and drives the complete remission of established immunologically cold mouse tumours

(2020) Aslan Mansurov et al.   Nature Biomedical Engineering

Metal–Organic Framework Derived Nanozymes in Biomedicine

(2020) Dongdong Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Enzymatically Formed Peptide Assemblies Sequestrate Proteins and Relocate Inhibitors to Selectively Kill Cancer Cells

(2020) Hongjian He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Manumycin polyketides act as molecular glues between UBR7 and P53

(2020) Yosuke Isobe et al.   Nature Chemical Biology

Prospecting for molecular glues

(2020) Willem den Besten et al.   Nature Chemical Biology

Rational discovery of molecular glue degraders via scalable chemical profiling

(2020) Cristina Mayor-Ruiz et al.   Nature Chemical Biology

Penetrable Nanoplatform for “Cold” Tumor Immune Microenvironment Reeducation

(2020) Qinjun Chen et al.   Advanced Science

Enzymatic Noncovalent Synthesis

(2020) Hongjian He et al.   CHEMICAL REVIEWS

Directly observing intracellular nanoparticle formation with nanocomputed tomography

(2020) Miaomiao Zhang et al.   Science Advances

Bispyrene-Based Self-Assembled Nanomaterials: In Vivo Self-Assembly, Transformation, and Biomedical Effects

(2019) Ping-Ping He et al.   ACCOUNTS OF CHEMICAL RESEARCH

Turning “Cold” Into “Hot” Tumors—Opportunities and Challenges for Radio-Immunotherapy Against Primary and Metastatic Brain Cancers

(2019) Lisa Sevenich   Frontiers in Oncology

Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling

(2019) Liqiang Pan et al.   CELL

Assemblies of Peptides in Complex Environment and Their Applications

(2019) Bing Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Dual-Bioresponsive Drug-Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade

(2019) Huitong Ruan et al.   ADVANCED MATERIALS

Tumor Microenvironment-Activatable Prodrug Vesicles for Nanoenabled Cancer Chemoimmunotherapy Combining Immunogenic Cell Death Induction and CD47 Blockade

(2019) Fangyuan Zhou et al.   ADVANCED MATERIALS

Enzyme‐Instructed Self‐Assembly (EISA) and Hydrogelation of Peptides

(2019) Jie Gao et al.   ADVANCED MATERIALS

Engineering Nanomolar Peptide LigandsThat Differentially Modulate EphA2 Receptor Signaling

(2019) Maricel Gomez-Soler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intercellular Instructed-Assembly Mimics Protein Dynamics To Induce Cell Spheroids

(2019) Huaimin Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Indenoisoquinoline Topoisomerase Inhibitors Strongly Bind and Stabilize the MYC Promoter G-Quadruplex and Downregulate MYC

(2019) Kai-Bo Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bromodomains: a new target class for drug development

(2019) Andrea G. Cochran et al.   NATURE REVIEWS DRUG DISCOVERY

Crizotinib-induced immunogenic cell death in non-small cell lung cancer

(2019) Peng Liu et al.   Nature Communications

Engineering nanoparticles to locally activate T cells in the tumor microenvironment

(2019) Dangge Wang et al.   Science Immunology

New power of self-assembling carbonic anhydrase inhibitor: Short peptide–constructed nanofibers inspire hypoxic cancer therapy

(2019) Jiayang Li et al.   Science Advances

Broadening and Enhancing Functions of Antibodies by Self-Assembling Multimerization at Cell Surface

(2019) Lian Li et al.   ACS Nano

Massively Evoking Immunogenic Cell Death by Focused Mitochondrial Oxidative Stress using an AIE Luminogen with a Twisted Molecular Structure

(2019) Chao Chen et al.   ADVANCED MATERIALS

In Situ Self-Assembled Nanofibers Precisely Target Cancer-Associated Fibroblasts for Improved Tumor Imaging

(2019) Xiao-Xiao Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular glue concept solidifies

(2019) Kheewoong Baek et al.   Nature Chemical Biology

Nanocarrier-Mediated Chemo-Immuno Therapy Arrested Cancer Progression and Induced Tumor Dormancy in Desmoplastic Melanoma

(2018) Qi Liu et al.   ACS Nano

Nanoparticle-mediated Immunogenic Cell Death Enables and Potentiates Cancer Immunotherapy

(2018) Xiaopin Duan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Minimalistic peptide supramolecular co-assembly: expanding the conformational space for nanotechnology

(2018) Pandeeswar Makam et al.   CHEMICAL SOCIETY REVIEWS

Supramolecular Polymer-Based Nanomedicine: High Therapeutic Performance and Negligible Long-Term Immunotoxicity

(2018) Guocan Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Controlled Tuning of the Properties in Optoelectronic Self-Sorted Gels

(2018) Emily R. Cross et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sequentially Responsive Therapeutic Peptide Assembling Nanoparticles for Dual-Targeted Cancer Immunotherapy

(2018) Keman Cheng et al.   NANO LETTERS

In situ formed reactive oxygen species–responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy

(2018) Chao Wang et al.   Science Translational Medicine

Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap

(2018) Wantong Song et al.   Nature Communications

Light-driven transformable optical agent with adaptive functions for boosting cancer surgery outcomes

(2018) Ji Qi et al.   Nature Communications

Combined local immunostimulatory radioisotope therapy and systemic immune checkpoint blockade imparts potent antitumour responses

(2018) Yu Chao et al.   Nature Biomedical Engineering

Binary Cooperative Prodrug Nanoparticles Improve Immunotherapy by Synergistically Modulating Immune Tumor Microenvironment

(2018) Bing Feng et al.   ADVANCED MATERIALS

Biorecognition: A key to drug-free macromolecular therapeutics

(2018) Jiyuan Yang et al.   BIOMATERIALS

Polymeric peptide pigments with sequence-encoded properties

(2017) Ayala Lampel et al.   SCIENCE

The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice

(2017) Lifeng Sun et al.   Science Signaling

AIEgen-based theranostic system: targeted imaging of cancer cells and adjuvant amplification of antitumor efficacy of paclitaxel

(2017) Chao Chen et al.   Chemical Science

Intracellular construction of topology-controlled polypeptide nanostructures with diverse biological functions

(2017) Li-Li Li et al.   Nature Communications

Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses

(2017) Guangbao Yang et al.   Nature Communications

The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice

(2017) Lifeng Sun et al.   Science Signaling

In situ activation of platelets with checkpoint inhibitors for post-surgical cancer immunotherapy

(2017) Chao Wang et al.   Nature Biomedical Engineering

A small peptide promotes EphA2 kinase-dependent signaling by stabilizing EphA2 dimers

(2016) Deo R. Singh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Lessons Learned: Dose Selection of Small Molecule-Targeted Oncology Drugs

(2016) J. M. Bullock et al.   CLINICAL CANCER RESEARCH

Cell Environment-Differentiated Self-Assembly of Nanofibers

(2016) Zhen Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tuning Cellular Uptake of Molecular Probes by Rational Design of Their Assembly into Supramolecular Nanoprobes

(2016) Lye Lin Lock et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tetraphenylethene-based highly emissive metallacage as a component of theranostic supramolecular nanoparticles

(2016) Guocan Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy

(2016) Chunbai He et al.   Nature Communications

Are Doses and Schedules of Small-Molecule Targeted Anticancer Drugs Recommended by Phase I Studies Realistic?

(2015) D. Roda et al.   CLINICAL CANCER RESEARCH

EphA2 Receptor Unliganded Dimers Suppress EphA2 Pro-tumorigenic Signaling

(2015) Deo R. Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Controlling Cancer Cell Fate Using Localized Biocatalytic Self-Assembly of an Aromatic Carbohydrate Amphiphile

(2015) Ricardo A. Pires et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A multiphase transitioning peptide hydrogel for suturing ultrasmall vessels

(2015) Daniel J. Smith et al.   Nature Nanotechnology

Transient assembly of active materials fueled by a chemical reaction

(2015) J. Boekhoven et al.   SCIENCE

Self-Assembly-Induced Far-Red/Near-Infrared Fluorescence Light-Up for Detecting and Visualizing Specific Protein–Peptide Interactions

(2014) Huaimin Wang et al.   ACS Nano

25th Anniversary Article: Supramolecular Materials for Regenerative Medicine

(2014) Job Boekhoven et al.   ADVANCED MATERIALS

Installing logic-gate responses to a variety of biological substances in supramolecular hydrogel–enzyme hybrids

(2014) Masato Ikeda et al.   Nature Chemistry

Blm-s , a BH3-Only Protein Enriched in Postmitotic Immature Neurons, Is Transcriptionally Upregulated by p53 during DNA Damage

(2014) Wei-Wen Liu et al.   Cell Reports

New perspectives on molecular targeted therapy in ovarian clear cell carcinoma

(2013) D S P Tan et al.   BRITISH JOURNAL OF CANCER

Higher-Order Assemblies in a New Paradigm of Signal Transduction

(2013) Hao Wu   CELL

Coassembly of Enantiomeric Amphipathic Peptides into Amyloid-Inspired Rippled β-Sheet Fibrils

(2012) Ria J. Swanekamp et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Imaging enzyme-triggered self-assembly of small molecules inside live cells

(2012) Yuan Gao et al.   Nature Communications

A biocompatible condensation reaction for controlled assembly of nanostructures in living cells

(2009) Gaolin Liang et al.   Nature Chemistry

Eph Receptors and Ephrins in Cancer: Common Themes and Controversies

(2008) J. Chen et al.   CANCER RESEARCH