In Situ Imaging of Formaldehyde in Live Mice with High Spatiotemporal Resolution Reveals Aldehyde Dehydrogenase-2 as a Potential Target for Alzheimer’s Disease Treatment

Oxidative stress in the pathogenesis of Alzheimer’s disease and cerebrovascular disease with therapeutic implications.

(2020) Anamaria Jurcau et al.   CNS & Neurological Disorders-Drug Targets

Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal

(2020) Tobias Baumann et al.   NATURE IMMUNOLOGY

One-carbon epigenetics and redox biology of neurodegeneration

(2020) Fabio Coppedè   FREE RADICAL BIOLOGY AND MEDICINE

Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans

(2020) Felix A. Dingler et al.   MOLECULAR CELL

Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome

(2020) Yasuyoshi Oka et al.   Science Advances

SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice

(2019) Yong Liu et al.   Nature Communications

Activity-Based Sensing Methods for Monitoring the Reactive Carbon Species Carbon Monoxide and Formaldehyde in Living Systems

(2019) Jun Ohata et al.   ACCOUNTS OF CHEMICAL RESEARCH

Chemiluminescent Probes for Activity-Based Sensing of Formaldehyde Released from Folate Degradation in Living Mice

(2018) Kevin J. Bruemmer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes

(2018) Alexandra Moraru et al.   Cell Metabolism

Mitochondrial translation requires folate-dependent tRNA methylation

(2018) Raphael J. Morscher et al.   NATURE

A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signalling

(2018) Michael J. Bollong et al.   NATURE

Development of a General Aza-Cope Reaction Trigger Applied to Fluorescence Imaging of Formaldehyde in Living Cells

(2017) Kevin J. Bruemmer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism

(2017) Guillermo Burgos-Barragan et al.   NATURE

A 2-aza-Cope reactivity-based platform for ratiometric fluorescence imaging of formaldehyde in living cells

(2017) Thomas F. Brewer et al.   Chemical Science

Evidence that endogenous formaldehyde produces immunogenic and atherogenic adduct epitopes

(2017) Jun Nakamura et al.   Scientific Reports

Measurement of Endogenous versus Exogenous Formaldehyde-Induced DNA-Protein Crosslinks in Animal Tissues by Stable Isotope Labeling and Ultrasensitive Mass Spectrometry

(2016) Y. Lai et al.   CANCER RESEARCH

Chemoproteomic profiling and discovery of protein electrophiles in human cells

(2016) Megan L. Matthews et al.   Nature Chemistry

A reactivity-based [18F]FDG probe for in vivo formaldehyde imaging using positron emission tomography

(2016) Wei Liu et al.   Chemical Science

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

(2015) Ping-Chih Ho et al.   CELL

A Reaction-Based Fluorescent Probe for Imaging of Formaldehyde in Living Cells

(2015) Aaron Roth et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Aza-Cope Reactivity-Based Fluorescent Probe for Imaging Formaldehyde in Living Cells

(2015) Thomas F. Brewer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen

(2015) Lucas B. Pontel et al.   MOLECULAR CELL

Nuclear Enrichment of Folate Cofactors and Methylenetetrahydrofolate Dehydrogenase 1 (MTHFD1) Protectde NovoThymidylate Biosynthesis during Folate Deficiency

(2014) Martha S. Field et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions of Oxidative Stress and Neurovascular Inflammation in the Pathogenesis of Traumatic Brain Injury

(2014) P. M. Abdul-Muneer et al.   MOLECULAR NEUROBIOLOGY

Formaldehyde in brain: an overlooked player in neurodegeneration?

(2013) Ketki Tulpule et al.   JOURNAL OF NEUROCHEMISTRY

Aging-associated excess formaldehyde leads to spatial memory deficits

(2013) Zhiqian Tong et al.   Scientific Reports

Mechanisms of human histone and nucleic acid demethylases

(2012) Louise J Walport et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Compartmentalization of Mammalian Folate-Mediated One-Carbon Metabolism

(2010) Anne S. Tibbetts et al.   Annual Review of Nutrition

Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart

(2008) Che-Hong Chen et al.   SCIENCE