Development of an efficient mAb quantification assay by LC-MS/MS using rapid on-bead digestion

Method Development and Validation of LC‐MS/MS‐Based Assay for the Simultaneous Quantitation of Trastuzumab and Pertuzumab in Cynomolgus Monkey Serum and its Application in Pharmacokinetic Study

(2020) Luo‐lan Gui et al.   BIOMEDICAL CHROMATOGRAPHY

Correlation Between Bevacizumab Exposure and Survival in Patients with Metastatic Colorectal Cancer

(2020) Apostolos Papachristos et al.   ONCOLOGIST

Simultaneous quantification of rituximab and eculizumab in human plasma by liquid chromatography-tandem mass spectrometry and comparison with rituximab ELISA kits

(2020) Aurélie Truffot et al.   CLINICAL BIOCHEMISTRY

Bottom-up sample preparation for the LC–MS/MS quantification of anti-cancer monoclonal antibodies in bio matrices

(2020) Karen AM de Jong et al.   Bioanalysis

Quantification of nivolumab in human plasma by LC-MS/HRMS and LC-MS/MS, comparison with ELISA

(2020) Aurélien Millet et al.   TALANTA

Correlation between nivolumab exposure and treatment outcomes in non–small-cell lung cancer

(2019) Edwin A. Basak et al.   EUROPEAN JOURNAL OF CANCER

Six-step workflow for the quantification of therapeutic monoclonal antibodies in biological matrices with liquid chromatography mass spectrometry – A tutorial

(2019) Mohsin El Amrani et al.   ANALYTICA CHIMICA ACTA

Monoclonal Antibody Monitoring

(2019) Mario Regazzi et al.   THERAPEUTIC DRUG MONITORING

Identification and characterization of co-purifying CHO host cell proteins in monoclonal antibody purification process

(2019) Xinrong Liu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Low pH Exposure During Immunoglobulin G Purification Methods Results in Aggregates That Avidly Bind Fcγ Receptors: Implications for Measuring Fc Dependent Antibody Functions

(2019) Ester Lopez et al.   Frontiers in Immunology

Development of a general method for quantifying IgG-based therapeutic monoclonal antibodies in human plasma using protein G purification coupled with a two internal standard calibration strategy using LC-MS/MS

(2018) Huai-Hsuan Chiu et al.   ANALYTICA CHIMICA ACTA

LC–MS/MS method for denosumab quantitation in human serum with rapid protein digestion using immobilized trypsin

(2018) Hiroaki Shida et al.   Bioanalysis

Therapeutic drug monitoring of monoclonal antibodies: Applicability based on their pharmacokinetic properties

(2018) Chiyo K. Imamura   Drug Metabolism and Pharmacokinetics

A new reliable, transposable and cost-effective assay for absolute quantification of total plasmatic bevacizumab by LC–MS/MS in human plasma comparing two internal standard calibration approaches

(2017) Rachel Legeron et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

LC–MS/MS determination of a human mAb drug candidate in rat serum using an isotopically labeled universal mAb internal standard

(2017) Wenkui Li et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

LC-MS/MS-Based Monitoring of In Vivo Protein Biotransformation: Quantitative Determination of Trastuzumab and Its Deamidation Products in Human Plasma

(2016) Peter Bults et al.   ANALYTICAL CHEMISTRY

Trastuzumab cardiotoxicity: from clinical trials to experimental studies

(2016) Balazs T Nemeth et al.   BRITISH JOURNAL OF PHARMACOLOGY

Quantification of active infliximab in human serum with liquid chromatography–tandem mass spectrometry using a tumor necrosis factor alpha -based pre-analytical sample purification and a stable isotopic labeled infliximab bio-similar as internal standard: A target-based, sensitive and cost-effective method

(2016) Mohsin El Amrani et al.   JOURNAL OF CHROMATOGRAPHY A

The flexibility of a generic LC–MS/MS method for the quantitative analysis of therapeutic proteins based on human immunoglobulin G and related constructs in animal studies

(2016) Christian Lanshoeft et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Post-pellet-digestion precipitation and solid phase extraction: A practical and efficient workflow to extract surrogate peptides for ultra-high performance liquid chromatography – tandem mass spectrometry bioanalysis of a therapeutic antibody in the low ng/mL range

(2015) Chao Gong et al.   JOURNAL OF CHROMATOGRAPHY A

Advances in Nanomaterial-Based Microwaves and Infrared Wave-Assisted Tryptic Digestion for Ultrafast Proteolysis and Rapid Detection by MALDI-MS

(2014) Suresh Kailasa et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Selective detection of complementarity-determining regions of monoclonal antibody by limiting protease access to the substrate: nano-surface and molecular-orientation limited proteolysis

(2013) Noriko Iwamoto et al.   ANALYST

Fully Validated LC-MS/MS Assay for the Simultaneous Quantitation of Coadministered Therapeutic Antibodies in Cynomolgus Monkey Serum

(2013) Hao Jiang et al.   ANALYTICAL CHEMISTRY

Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition

(2013) Jean-Philippe Lambert et al.   NATURE METHODS

Mass spectrometry approaches to study mammalian kinase and phosphatase associated proteins

(2012) Michelle J. Kean et al.   METHODS

Direct Identification and Quantification of Aspartyl Succinimide in an IgG2 mAb by RapiGest Assisted Digestion

(2009) Holly Z. Huang et al.   ANALYTICAL CHEMISTRY

Accelerated tryptic digestion for the analysis of biopharmaceutical monoclonal antibodies in plasma by liquid chromatography with tandem mass spectrometric detection

(2009) Antoine Lesur et al.   JOURNAL OF CHROMATOGRAPHY A