Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection

Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium

(2021) Jessica K. Fiege et al.   PLoS Pathogens

SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery

(2021) Apoorva Mulay et al.   Cell Reports

Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes

(2021) Neal G. Ravindra et al.   PLOS BIOLOGY

Disparate temperature-dependent virus–host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium

(2021) Philip V’kovski et al.   PLOS BIOLOGY

Provisional Mortality Data — United States, 2020

(2021) Farida B. Ahmad et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

SARS-CoV-2 infects an upper airway model derived from induced pluripotent stem cells

(2021) Ivo Djidrovski et al.   STEM CELLS

SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance

(2021) Rémy Robinot et al.   Nature Communications

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

(2020) Carly G.K. Ziegler et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

(2020) Chuan Qin et al.   CLINICAL INFECTIOUS DISEASES

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

and Animal Models for SARS-CoV-2 research

(2020) Kazuo Takayama   TRENDS IN PHARMACOLOGICAL SCIENCES

Single Cell Reconstruction of Human Basal Cell Diversity in Normal and IPF Lung

(2020) Gianni Carraro et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Incidence of co-infections and superinfections in hospitalised patients with COVID-19: a retrospective cohort study

(2020) Carolina Garcia-Vidal et al.   CLINICAL MICROBIOLOGY AND INFECTION

Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells

(2020) Na Zhu et al.   Nature Communications

Interplay between SARS-CoV-2 and the type I interferon response

(2020) Margarida Sa Ribero et al.   PLoS Pathogens

Human coronaviruses 229E and OC43 replicate and induce distinct anti-viral responses in differentiated primary human bronchial epithelial cells

(2020) Su-Ling Loo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses

(2020) Ruofan Wang et al.   CELL

Modeling Multi-organ Infection by SARS-CoV-2 Using Stem Cell Technology

(2020) Camille R. Simoneau et al.   Cell Stem Cell

Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infection

(2020) Rongjuan Pei et al.   Protein & Cell

Generation of lung organoids from human pluripotent stem cells in vitro

(2019) Alyssa J. Miller et al.   Nature Protocols

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

The immature electrophysiological phenotype of iPSC-CMs still hampers in vitro drug screening: Special focus on I K1

(2018) Birgit Goversen et al.   PHARMACOLOGY & THERAPEUTICS

Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium

(2018) Katherine B. McCauley et al.   Stem Cell Reports

Prospective isolation of NKX2-1–expressing human lung progenitors derived from pluripotent stem cells

(2017) Finn Hawkins et al.   JOURNAL OF CLINICAL INVESTIGATION

A three-dimensional model of human lung development and disease from pluripotent stem cells

(2017) Ya-Wen Chen et al.   NATURE CELL BIOLOGY

Long-term expansion of alveolar stem cells derived from human iPS cells in organoids

(2017) Yuki Yamamoto et al.   NATURE METHODS

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

(2016) Rudragouda Channappanavar et al.   Cell Host & Microbe

Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells

(2016) Hongmei Mou et al.   Cell Stem Cell

Induced pluripotent stem cell technology: a decade of progress

(2016) Yanhong Shi et al.   NATURE REVIEWS DRUG DISCOVERY

Directed Induction of Functional Multi-ciliated Cells in Proximal Airway Epithelial Spheroids from Human Pluripotent Stem Cells

(2016) Satoshi Konishi et al.   Stem Cell Reports

Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Insights Into Molecular, Cellular, and Functional Phenotypes

(2015) I. Karakikes et al.   CIRCULATION RESEARCH

The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells

(2015) Sarah X L Huang et al.   Nature Protocols

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Targeted Correction and Restored Function of the CFTR Gene in Cystic Fibrosis Induced Pluripotent Stem Cells

(2015) Ana M. Crane et al.   Stem Cell Reports

Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses

(2014) V. D. Menachery et al.   mBio

Generation of Alveolar Epithelial Spheroids via Isolated Progenitor Cells from Human Pluripotent Stem Cells

(2014) Shimpei Gotoh et al.   Stem Cell Reports

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Isolation and Characterization of Current Human Coronavirus Strains in Primary Human Epithelial Cell Cultures Reveal Differences in Target Cell Tropism

(2013) R. Dijkman et al.   JOURNAL OF VIROLOGY

Efficient generation of lung and airway epithelial cells from human pluripotent stem cells

(2013) Sarah X L Huang et al.   NATURE BIOTECHNOLOGY

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Efficient Derivation of Purified Lung and Thyroid Progenitors from Embryonic Stem Cells

(2012) Tyler A. Longmire et al.   Cell Stem Cell

Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells

(2011) Michael D Green et al.   NATURE BIOTECHNOLOGY

Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling

(2010) J. R. Rock et al.   Disease Models & Mechanisms

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS