Combined control of the fibroblast contractile program by YAP and TAZ

IGF1R controls mechanosignaling in myofibroblasts required for pulmonary alveologenesis

(2021) Hua He et al.   JCI Insight

SKI activates the Hippo pathway via LIMD1 to inhibit cardiac fibroblast activation

(2021) Natalie M. Landry et al.   BASIC RESEARCH IN CARDIOLOGY

Myofibroblast contraction is essential for generating and regenerating the gas-exchange surface

(2020) Rongbo Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis

(2020) Taylor S. Adams et al.   Science Advances

A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer

(2020) Michal Shreberk-Shaked et al.   CANCER RESEARCH

PGC1α repression in IPF fibroblasts drives a pathologic metabolic, secretory and fibrogenic state

(2019) Nunzia Caporarello et al.   THORAX

Hippo pathway deletion in adult resting cardiac fibroblasts initiates a cell state transition with spontaneous and self-sustaining fibrosis

(2019) Yang Xiao et al.   GENES & DEVELOPMENT

TGFβ-induced fibroblast activation requires persistent and targeted HDAC-mediated gene repression

(2019) Dakota L. Jones et al.   JOURNAL OF CELL SCIENCE

Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis

(2019) Andrew J. Haak et al.   Science Translational Medicine

Non-canonical (non-SMAD2/3) TGF-β signaling in fibrosis: Mechanisms and targets

(2019) Kenneth W. Finnson et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

TGF-β in fibrosis by acting as a conductor for contractile properties of myofibroblasts

(2019) Alexandre Vallée et al.   Cell and Bioscience

TAZ responds to fluid shear stress to regulate the cell cycle

(2018) Hyun Jung Lee et al.   CELL CYCLE

Pulmonary pericytes regulate lung morphogenesis

(2018) Katsuhiro Kato et al.   Nature Communications

Salvianolic acid A targeting the transgelin-actin complex to enhance vasoconstriction

(2018) Weilong Zhong et al.   EBioMedicine

YAP and TAZ are distinct effectors of corneal myofibroblast transformation

(2018) Santoshi Muppala et al.   EXPERIMENTAL EYE RESEARCH

Mutual dependence of the MRTF–SRF and YAP–TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics

(2017) Charles T. Foster et al.   GENES & DEVELOPMENT

Yap/Taz Deletion in Gli+Cell-Derived Myofibroblasts Attenuates Fibrosis

(2017) Ming Liang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

YAP regulates cell mechanics by controlling focal adhesion assembly

(2017) Giorgia Nardone et al.   Nature Communications

TAZ contributes to pulmonary fibrosis by activating profibrotic functions of lung fibroblasts

(2017) Satoshi Noguchi et al.   Scientific Reports

YAP/TAZ Are Mechanoregulators of TGF- -Smad Signaling and Renal Fibrogenesis

(2016) S. G. Szeto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TGF-β Targets the Hippo Pathway Scaffold RASSF1A to Facilitate YAP/SMAD2 Nuclear Translocation

(2016) Dafni-Eleftheria Pefani et al.   MOLECULAR CELL

The eukaryotic promoter database in its 30th year: focus on non-vertebrate organisms

(2016) René Dreos et al.   NUCLEIC ACIDS RESEARCH

YAP1 Is a Driver of Myofibroblast Differentiation in Normal and Diseased Fibroblasts

(2015) Bram Piersma et al.   AMERICAN JOURNAL OF PATHOLOGY

Hippo and TGF-β interplay in the lung field

(2015) Akira Saito et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

(2015) Fei Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hippo signaling is required for Notch-dependent smooth muscle differentiation of neural crest

(2015) L. J. Manderfield et al.   DEVELOPMENT

Epigenetics of idiopathic pulmonary fibrosis

(2015) Ivana V. Yang et al.   Translational Research

YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

(2015) Claudia Stein et al.   PLoS Genetics

Mechanism of Calponin Stabilization of Cross-Linked Actin Networks

(2014) Mikkel Herholdt Jensen et al.   BIOPHYSICAL JOURNAL

The Transcriptional Regulators TAZ and YAP Direct Transforming Growth Factor β-induced Tumorigenic Phenotypes in Breast Cancer Cells

(2014) Samantha E. Hiemer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGF- -induced differentiation into myofibroblasts involves specific regulation of two MKL1 isoforms

(2014) M. A. Scharenberg et al.   JOURNAL OF CELL SCIENCE

Role of IGF-1 pathway in lung fibroblast activation

(2013) Chi F Hung et al.   RESPIRATORY RESEARCH

Improved throughput traction microscopy reveals pivotal role for matrix stiffness in fibroblast contractility and TGF-β responsiveness

(2012) Aleksandar Marinković et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Thrombospondin1 in tissue repair and fibrosis: TGF-β-dependent and independent mechanisms

(2012) Mariya T. Sweetwyne et al.   MATRIX BIOLOGY

Transglutaminase 2 and Its Role in Pulmonary Fibrosis

(2011) Keith C. Olsen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Myocardin-Related Transcription Factors A and B Are Key Regulators of TGF-β1-Induced Fibroblast to Myofibroblast Differentiation

(2011) Beverly J. Crider et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A Multiwell Platform for Studying Stiffness-Dependent Cell Biology

(2011) Justin D. Mih et al.   PLoS One

Transcriptional Coactivator with PDZ-binding Motif Is Essential for Normal Alveolarization in Mice

(2009) Akihisa Mitani et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

(2008) Xaralabos Varelas et al.   NATURE CELL BIOLOGY