Mitochondrial DNA damage as driver of cellular outcomes

DNA Polymerase β Outperforms DNA Polymerase γ in Key Mitochondrial Base Excision Repair Activities

(2021) Beverly A. Baptiste et al.   DNA REPAIR

p53 is required for nuclear but not mitochondrial DNA damage-induced degeneration

(2021) Matthew J. Geden et al.   Cell Death & Disease

Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance

(2021) Marco Tigano et al.   NATURE

Mitochondrial genome stability in human: understanding the role of DNA repair pathways

(2021) Sumedha Dahal et al.   BIOCHEMICAL JOURNAL

Biallelic variants in LIG3 cause a novel mitochondrial neurogastrointestinal encephalomyopathy

(2021) Elena Bonora et al.   BRAIN

The Mitochondrial Response to DNA Damage

(2021) Ziye Rong et al.   Frontiers in Cell and Developmental Biology

Cellular functions of the protein kinase ATM and their relevance to human disease

(2021) Ji-Hoon Lee et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chemotherapy and peripheral neuropathy

(2021) Tiffany Li et al.   NEUROLOGICAL SCIENCES

Interactions of Mitochondrial Transcription Factor A with DNA Damage: Mechanistic Insights and Functional Implications

(2021) Krystie Chew et al.   Genes

The interplay between mitochondrial functionality and genome integrity in the prevention of human neurologic diseases

(2021) Mariarosaria D'Errico et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Mitochondrial DNA heteroplasmy in disease and targeted nuclease‐based therapeutic approaches

(2020) Nadee Nissanka et al.   EMBO REPORTS

Therapeutic Manipulation of mtDNA Heteroplasmy: A Shifting Perspective

(2020) Christopher B. Jackson et al.   TRENDS IN MOLECULAR MEDICINE

Mammalian mitochondrial DNA replication and mechanisms of deletion formation

(2020) Maria Falkenberg et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Consequences of compromised mitochondrial genome integrity

(2020) Margaret A. Gustafson et al.   DNA REPAIR

Single Nucleotide Resolution Analysis Reveals Pervasive, Long-Lasting DNA Methylation Changes by Developmental Exposure to a Mitochondrial Toxicant

(2020) Oswaldo A. Lozoya et al.   Cell Reports

Mitochondria signaling to the epigenome: A novel role for an old organelle

(2020) Janine Hertzog Santos   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy

(2019) Piotr K. Kopinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial transcription factor A promotes DNA strand cleavage at abasic sites

(2019) Wenyan Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemoptogenetic damage to mitochondria causes rapid telomere dysfunction

(2019) Wei Qian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial heteroplasmy beyond the oocyte bottleneck

(2019) Jelle van den Ameele et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Role of mitochondrial dysfunction in the pathophysiology of DNA repair disorders

(2018) Mateus Prates Mori et al.   CELL BIOLOGY INTERNATIONAL

Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations

(2018) Qiuying Chen et al.   Cell Metabolism

Assembly of mammalian oxidative phosphorylation complexes I–V and supercomplexes

(2018) Alba Signes et al.   Essays in Biochemistry

An overview of mammalian mitochondrial DNA replication mechanisms

(2018) Takehiro Yasukawa et al.   JOURNAL OF BIOCHEMISTRY

Mitochondrial OXPHOS complex assembly lines

(2018) Luke E. Formosa et al.   NATURE CELL BIOLOGY

Structural rearrangements in the mitochondrial genome of Drosophila melanogaster induced by elevated levels of the replicative DNA helicase

(2018) Grzegorz L Ciesielski et al.   NUCLEIC ACIDS RESEARCH

Linear mitochondrial DNA is rapidly degraded by components of the replication machinery

(2018) Viktoriya Peeva et al.   Nature Communications

The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions

(2018) Nadee Nissanka et al.   Nature Communications

Mitochondrial nicotinamide adenine dinucleotide reduced (NADH) oxidation links the tricarboxylic acid (TCA) cycle with methionine metabolism and nuclear DNA methylation

(2018) Oswaldo A. Lozoya et al.   PLOS BIOLOGY

Inhibition of mitochondrial translation in fibroblasts from a patient expressing the KARS p.(Pro228Leu) variant and presenting with sensorineural deafness, developmental delay and lactic acidosis

(2018) Benedetta Ruzzenente et al.   HUMAN MUTATION

N-glycanase NGLY1 regulates mitochondrial homeostasis and inflammation through NRF1

(2018) Kun Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation

(2018) Sandra R. Bacman et al.   NATURE MEDICINE

Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo

(2018) Payam A. Gammage et al.   NATURE MEDICINE

DNA damage related crosstalk between the nucleus and mitochondria

(2017) Mohammad Saki et al.   FREE RADICAL BIOLOGY AND MEDICINE

DNA Polymerase Beta Participates in Mitochondrial DNA Repair

(2017) P. Sykora et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation

(2017) Xin Liu et al.   NATURE CELL BIOLOGY

Selective mitochondrial DNA degradation following double-strand breaks

(2017) Amandine Moretton et al.   PLoS One

Inhibiting Mitochondrial DNA Ligase IIIα Activates Caspase 1–Dependent Apoptosis in Cancer Cells

(2016) Annahita Sallmyr et al.   CANCER RESEARCH

Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner

(2016) Milena Pinto et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism

(2016) Joni Nikkanen et al.   Cell Metabolism

Mitochondrial DNA damage induced autophagy cell death and disease

(2016) Bennett Van Houten   Frontiers in Bioscience-Landmark

Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck

(2016) Mingkun Li et al.   GENOME RESEARCH

TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions

(2016) Inmaculada Martínez-Reyes et al.   MOLECULAR CELL

Homologous DNA strand exchange activity of the human mitochondrial DNA helicase TWINKLE

(2016) Doyel Sen et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial polymerase gamma dysfunction and aging cause cardiac nuclear DNA methylation changes

(2016) Christopher A. Koczor et al.   PHYSIOLOGICAL GENOMICS

Mitochondrial dysfunction remodels one-carbon metabolism in human cells

(2016) Xiaoyan Robert Bao et al.   eLife

Base Excision Repair in the Mitochondria

(2015) Aishwarya Prakash et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication

(2015) Bertil Macao et al.   Nature Communications

DNA Damage, DNA Repair, Aging, and Neurodegeneration

(2015) Scott Maynard et al.   Cold Spring Harbor Perspectives in Medicine

The Red Queen in mitochondria: cyto-nuclear co-evolution, hybrid breakdown and human disease

(2015) Jui-Yu Chou et al.   Frontiers in Genetics

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Mitochondrial genome maintenance in health and disease

(2014) William C. Copeland et al.   DNA REPAIR

Mitochondrial DNA damage: Molecular marker of vulnerable nigral neurons in Parkinson's disease

(2014) Laurie H. Sanders et al.   NEUROBIOLOGY OF DISEASE

Cytoplasmic Irradiation Results in Mitochondrial Dysfunction and DRP1-Dependent Mitochondrial Fission

(2013) B. Zhang et al.   CANCER RESEARCH

Persistent damage induces mitochondrial DNA degradation

(2013) Inna N. Shokolenko et al.   DNA REPAIR

The role of DNA repair in brain related disease pathology

(2013) Chandrika Canugovi et al.   DNA REPAIR

Intrinsic mitochondrial DNA repair defects in Ataxia Telangiectasia

(2013) Nilesh K. Sharma et al.   DNA REPAIR

Mitochondrial deficiency in Cockayne syndrome

(2013) Morten Scheibye-Knudsen et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Mitochondria as a Target of Environmental Toxicants

(2013) Joel N. Meyer et al.   TOXICOLOGICAL SCIENCES

Mitochondrial DNA Genetics and the Heteroplasmy Conundrum in Evolution and Disease

(2013) D. C. Wallace et al.   Cold Spring Harbor Perspectives in Biology

The Maintenance of Mitochondrial DNA Integrity--Critical Analysis and Update

(2013) M. Alexeyev et al.   Cold Spring Harbor Perspectives in Biology

Base Excision Repair

(2013) H. E. Krokan et al.   Cold Spring Harbor Perspectives in Biology

Mitochondrial DNA damage and its consequences for mitochondrial gene expression

(2012) Susan D. Cline   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Oxidants and not alkylating agents induce rapid mtDNA loss and mitochondrial dysfunction

(2012) Amy M. Furda et al.   DNA REPAIR

OXPHOS mutations and neurodegeneration

(2012) Werner J H Koopman et al.   EMBO JOURNAL

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Human Mitochondrial DNA Helicase TWINKLE Is Both an Unwinding and Annealing Helicase

(2012) Doyel Sen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1- and Parkin-mediated mitophagy at a glance

(2012) Seok Min Jin et al.   JOURNAL OF CELL SCIENCE

Effects of DNA lesions on the transcription reaction of mitochondrial RNA polymerase: implications for bypass RNA synthesis on oxidative DNA lesions

(2012) Nozomi Nakanishi et al.   MUTAGENESIS

DNA damage by singlet oxygen and cellular protective mechanisms

(2012) Lucymara F. Agnez-Lima et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Minimizing the damage: repair pathways keep mitochondrial DNA intact

(2012) Lawrence Kazak et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human Cockayne syndrome B protein reciprocally communicates with mitochondrial proteins and promotes transcriptional elongation

(2012) Brian R. Berquist et al.   NUCLEIC ACIDS RESEARCH

Apoptosis Induced by Persistent Single-strand Breaks in Mitochondrial Genome

(2011) Anne W. Tann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Replication stalling by catalytically impaired Twinkle induces mitochondrial DNA rearrangements in cultured cells

(2011) Jaakko L.O. Pohjoismäki et al.   MITOCHONDRION

Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair

(2011) Deniz Simsek et al.   NATURE

DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair

(2011) Yankun Gao et al.   NATURE

The mitochondrial transcription factor A functions in mitochondrial base excision repair

(2010) Chandrika Canugovi et al.   DNA REPAIR

Arrest of human mitochondrial RNA polymerase transcription by the biological aldehyde adduct of DNA, M 1 dG

(2010) Susan D. Cline et al.   NUCLEIC ACIDS RESEARCH

Consequences of Cytoplasmic Irradiation: Studies from Microbeam

(2009) Hongning ZHOU et al.   JOURNAL OF RADIATION RESEARCH

Intra- and inter-molecular recombination of mitochondrial DNA after in vivo induction of multiple double-strand breaks

(2009) S. R. Bacman et al.   NUCLEIC ACIDS RESEARCH

Oxidative stress induces degradation of mitochondrial DNA

(2009) Inna Shokolenko et al.   NUCLEIC ACIDS RESEARCH

Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells

(2008) Muralidhar L Hegde et al.   CELL RESEARCH

Generation of ρ 0 cells utilizing a mitochondrially targeted restriction endonuclease and comparative analyses

(2008) Alexandra Kukat et al.   NUCLEIC ACIDS RESEARCH