Journal
JOURNAL OF RADIATION RESEARCH
Volume 50, Issue -, Pages A59-A65Publisher
OXFORD UNIV PRESS
DOI: 10.1269/jrr.08120S
Keywords
Cytoplasm; Radiation; Microbeam; Bystander Effect; ROS; NF-kappa B; ATM
Funding
- National Institutes of Health [CA 49062, ES 12888, U 19 AI067773]
Ask authors/readers for more resources
The prevailing dogma for radiation biology is that genotoxic effects of ionizing radiation Such as mutations and carcinogenesis are attributed mainly to direct damage to the nucleus. However, with the development of microbeam that can target precise positions inside the cells, accumulating evidences have shown that energy deposit by radiation in nuclear DNA is not required to trigger the damage, extra-nuclear or extra-cellular radiation could induce the similar biological effects its well. This review will summarize the biological responses after cytoplasm irradiated by microbeam, and the possible mechanisms involved in cytoplasmic irradiation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available