Drosophila p38 MAPK interacts with BAG‐3/starvin to regulate age‐dependent protein homeostasis

Regulation of Age-Related Protein Toxicity

(2021) Anita Pras et al.   Frontiers in Cell and Developmental Biology

Molecular Basis of Neuronal Autophagy in Ageing: Insights from Caenorhabditis elegans

(2021) Georgios Konstantinidis et al.   Cells

Drosophila NUAK functions with Starvin/BAG3 in autophagic protein turnover

(2020) David Brooks et al.   PLoS Genetics

Evolutionarily conserved transcription factors drive the oxidative stress response in Drosophila

(2020) Sarah M. Ryan et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Lamin B is a target for selective nuclear PQC by BAG3: implication for nuclear envelopathies

(2019) Manish K. Gupta et al.   Cell Death & Disease

Enhanced autophagic-lysosomal activity and increased BAG3-mediated selective macroautophagy as adaptive response of neuronal cells to chronic oxidative stress

(2019) Debapriya Chakraborty et al.   Redox Biology

Protein Aggregation in a Nutshell: The Splendid Molecular Architecture of the Dreaded Amyloid Fibrils

(2019) Dániel Horváth et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Causative Links between Protein Aggregation and Oxidative Stress: A Review

(2019) Elise Lévy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

HSPB8 and BAG3 cooperate to promote spatial sequestration of ubiquitinated proteins and coordinate the cellular adaptive response to proteasome insufficiency

(2018) Solenn M. Guilbert et al.   FASEB JOURNAL

Suppression of myopathic lamin mutations by muscle-specific activation of AMPK and modulation of downstream signaling

(2018) Sahaana Chandran et al.   HUMAN MOLECULAR GENETICS

The Role of the Multifunctional BAG3 Protein in Cellular Protein Quality Control and in Disease

(2017) Elisabeth Stürner et al.   Frontiers in Molecular Neuroscience

Proteostasis, oxidative stress and aging

(2017) Ioanna Korovila et al.   Redox Biology

Lamin Mutations Accelerate Aging via Defective Export of Mitochondrial mRNAs through Nuclear Envelope Budding

(2016) Yihang Li et al.   CURRENT BIOLOGY

Breaking BAG: The Co-Chaperone BAG3 in Health and Disease

(2016) Christian Behl   TRENDS IN PHARMACOLOGICAL SCIENCES

Prelamin A processing, accumulation and distribution in normal cells and laminopathy disorders

(2016) Andrea Casasola et al.   Nucleus

Prelamin A processing, accumulation and distribution in normal cells and laminopathy disorders

(2016) Andrea Casasola et al.   Nucleus

Atg7 Knockdown Augments Concanavalin A-Induced Acute Hepatitis through an ROS-Mediated p38/MAPK Pathway

(2016) Yan Zhuang et al.   PLoS One

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

(2015) Yoshinori Katsuragi et al.   FEBS Journal

Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1

(2015) Laura Schnöder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin Protects Against Misfolded SOD1 Toxicity by Promoting Its Aggresome Formation and Autophagic Clearance

(2015) Cheryl Yung et al.   MOLECULAR NEUROBIOLOGY

Myopathic Lamin Mutations Cause Reductive Stress and Activate the Nrf2/Keap-1 Pathway

(2015) George Dialynas et al.   PLoS Genetics

HspB8 and Bag3: A new chaperone complex targeting misfolded proteins to macroautophagy

(2014) Serena Carra et al.   Autophagy

p38 MAP Kinase Regulates Circadian Rhythms in Drosophila

(2014) Alysia D. Vrailas-Mortimer et al.   JOURNAL OF BIOLOGICAL RHYTHMS

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells

(2014) Sian M. Henson et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of p38 and changes in mitochondria accompany autophagy to premature senescence-like phenotype switch upon chronic exposure to selenite in colon fibroblasts

(2014) Emil Rudolf et al.   TOXICOLOGY LETTERS

Cellular Mechanotransduction Relies on Tension-Induced and Chaperone-Assisted Autophagy

(2013) Anna Ulbricht et al.   CURRENT BIOLOGY

Lamin aggregation is an early sensor of porphyria-induced liver injury

(2013) A. Singla et al.   JOURNAL OF CELL SCIENCE

In Vivo Interaction Proteomics Reveal a Novel p38 Mitogen-Activated Protein Kinase/Rack1 Pathway Regulating Proteostasis in Drosophila Muscle

(2013) V. E. Belozerov et al.   MOLECULAR AND CELLULAR BIOLOGY

Proteasomes Activate Aggresome Disassembly and Clearance by Producing Unanchored Ubiquitin Chains

(2013) Rui Hao et al.   MOLECULAR CELL

DNAJB6 myopathy in an Asian cohort and cytoplasmic/nuclear inclusions

(2013) Takatoshi Sato et al.   NEUROMUSCULAR DISORDERS

Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan

(2013) A. Rana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid β-protein oligomers and Alzheimer’s disease

(2013) Eric Y Hayden et al.   Alzheimers Research & Therapy

The Caenorhabditis elegans JNK Signaling Pathway Activates Expression of Stress Response Genes by Derepressing the Fos/HDAC Repressor Complex

(2013) Ayuna Hattori et al.   PLoS Genetics

A Drosophila Model of High Sugar Diet-Induced Cardiomyopathy

(2013) Jianbo Na et al.   PLoS Genetics

Loss of Drosophila A-type lamin C initially causes tendon abnormality including disintegration of cytoskeleton and nuclear lamina in muscular defects

(2012) Ryo Uchino et al.   DEVELOPMENTAL BIOLOGY

Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation

(2012) Aurelia Barascu et al.   EMBO JOURNAL

A survey of the protective effects of some commercially available antioxidant supplements in genetically and chemically induced models of oxidative stress in Drosophila melanogaster

(2012) Alysia Vrailas-Mortimer et al.   EXPERIMENTAL GERONTOLOGY

The nuclear lamins: flexibility in function

(2012) Brian Burke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Different Function of Single Phosphorylation Sites of Drosophila melanogaster Lamin Dm and Lamin C

(2012) Magdalena Zaremba-Czogalla et al.   PLoS One

BAG3 and friends: Co-chaperones in selective autophagy during aging and disease

(2011) Christian Behl   Autophagy

Silibinin Activated p53 and Induced Autophagic Death in Human Fibrosarcoma HT1080 Cells via Reactive Oxygen Species-p38 and c-Jun N-Terminal Kinase Pathways

(2011) Wen-Jun Duan et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

A Protein Complex Network of Drosophila melanogaster

(2011) K.G. Guruharsha et al.   CELL

A Muscle-Specific p38 MAPK/Mef2/MnSOD Pathway Regulates Stress, Motor Function, and Life Span in Drosophila

(2011) Alysia Vrailas-Mortimer et al.   DEVELOPMENTAL CELL

BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins

(2011) Martin Gamerdinger et al.   EMBO REPORTS

Autophagy regulates ROS-induced cellular senescence via p21 in a p38 MAPKα dependent manner

(2011) Yi Luo et al.   EXPERIMENTAL GERONTOLOGY

A laminopathic mutation disrupting lamin filament assembly causes disease-like phenotypes in Caenorhabditis elegans

(2011) Erin M. Bank et al.   MOLECULAR BIOLOGY OF THE CELL

Chaperone-mediated hierarchical control in targeting misfolded proteins to aggresomes

(2011) Xingqian Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Continuous administration of poloxamer 188 reduces overload-induced muscular atrophy in dysferlin-deficient SJL mice

(2011) Naoki Suzuki et al.   NEUROSCIENCE RESEARCH

Aging as an Event of Proteostasis Collapse

(2011) R. C. Taylor et al.   Cold Spring Harbor Perspectives in Biology

Identification of new in vivo phosphosites on lamin Dm - the evidence of heterogeneity of phosphorylation sites in differentDrosophilatissues

(2011) Magdalena Zaremba-Czogalla et al.   Nucleus

Chaperone-assisted degradation: multiple paths to destruction

(2010) Nadja Kettern et al.   BIOLOGICAL CHEMISTRY

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

(2010) Fabio Demontis et al.   CELL

Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance

(2010) Verena Arndt et al.   CURRENT BIOLOGY

New insights into the function of Atg9

(2010) Jemma L. Webber et al.   FEBS LETTERS

Identification of theDrosophilaOrtholog of HSPB8

(2010) Serena Carra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Farnesylated Nuclear Proteins Kugelkern and Lamin Dm0 Affect Nuclear Morphology by Directly Interacting with the Nuclear Membrane

(2010) Maria Polychronidou et al.   MOLECULAR BIOLOGY OF THE CELL

MCP-1 causes cardiomyoblast death via autophagy resulting from ER stress caused by oxidative stress generated by inducing a novel zinc-finger protein, MCPIP

(2009) Craig W. Younce et al.   BIOCHEMICAL JOURNAL

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

(2009) Martin Gamerdinger et al.   EMBO JOURNAL

Overexpression of IGF-1 in Muscle Attenuates Disease in a Mouse Model of Spinal and Bulbar Muscular Atrophy

(2009) Isabella Palazzolo et al.   NEURON

A Comparative Study of Drosophila and Human A-Type Lamins

(2009) Sandra R. Schulze et al.   PLoS One

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

(2009) A. Ben-Zvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The farnesylated nuclear proteins KUGELKERN and LAMIN B promote aging-like phenotypes inDrosophilaflies

(2008) Annely Brandt et al.   AGING CELL

Mutation in BAG3 causes severe dominant childhood muscular dystrophy

(2008) Duygu Selcen et al.   ANNALS OF NEUROLOGY

Simultaneous Inference in General Parametric Models

(2008) Torsten Hothorn et al.   BIOMETRICAL JOURNAL

Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS–p38–p53 pathway

(2008) Bo Liu et al.   CANCER LETTERS

Improvement of Photoaffinity SPR Imaging Platform and Determination of the Binding Site of p62/SQSTM1 to p38 MAP Kinase

(2008) Akiko Saito et al.   Chemistry-An Asian Journal

Gone with the Wnt/Notch: stem cells in laminopathies, progeria, and aging

(2008) Eran Meshorer et al.   JOURNAL OF CELL BIOLOGY

CHIP Deficiency Decreases Longevity, with Accelerated Aging Phenotypes Accompanied by Altered Protein Quality Control

(2008) J.-N. Min et al.   MOLECULAR AND CELLULAR BIOLOGY

A Member of the p38 Mitogen-Activated Protein Kinase Family Is Responsible for Transcriptional Induction of Dopa decarboxylase in the Epidermis of Drosophila melanogaster during the Innate Immune Response

(2008) M. M. Davis et al.   MOLECULAR AND CELLULAR BIOLOGY