Spatiotemporally Controllable Distribution of Combination Therapeutics in Solid Tumors by Dually Modified Bacteria

Bifidobacterium bifidum strains synergize with immune checkpoint inhibitors to reduce tumour burden in mice

(2021) Se-Hoon Lee et al.   Nature Microbiology

Polymerization‐Mediated Multifunctionalization of Living Cells for Enhanced Cell‐Based Therapy

(2021) Chao Pan et al.   ADVANCED MATERIALS

Mucosal immunity–mediated modulation of the gut microbiome by oral delivery of probiotics into Peyer’s patches

(2021) Sisi Lin et al.   Science Advances

Increased Tumor Penetration of Single-Domain Antibody Drug Conjugates Improves In Vivo Efficacy in Prostate Cancer Models

(2020) Ian Nessler et al.   CANCER RESEARCH

Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies

(2020) Candice R. Gurbatri et al.   Science Translational Medicine

Reprogramming Tumor Microenvironment with Photothermal Therapy

(2020) Qinglian Hu et al.   BIOCONJUGATE CHEMISTRY

Measurement of absorption and reduced scattering coefficients in Asian human epidermis, dermis, and subcutaneous fat tissues in the 400- to 1100-nm wavelength range for optical penetration depth and energy deposition analysis

(2020) Yu Shimojo et al.   JOURNAL OF BIOMEDICAL OPTICS

PD-1: A Driver or Passenger of T Cell Exhaustion?

(2020) Xing He et al.   MOLECULAR CELL

On‐Demand Bacterial Reactivation by Restraining within a Triggerable Nanocoating

(2020) Pingping Feng et al.   ADVANCED MATERIALS

Nanocarrier-mediated immunogenic chemotherapy for triple negative breast cancer

(2020) Yun Liu et al.   JOURNAL OF CONTROLLED RELEASE

Bioinspired oral delivery of gut microbiota by self-coating with biofilms

(2020) Xinyue Wang et al.   Science Advances

Human intratumoral therapy: Linking drug properties and tumor transport of drugs in clinical trials

(2020) Aric Huang et al.   JOURNAL OF CONTROLLED RELEASE

Bioengineered bacterial vesicles as biological nano-heaters for optoacoustic imaging

(2019) Vipul Gujrati et al.   Nature Communications

Nanophotosensitizer-engineered Salmonella bacteria with hypoxia targeting and photothermal-assisted mutual bioaccumulation for solid tumor therapy

(2019) Fuming Chen et al.   BIOMATERIALS

Photothermal therapy mediated by phase-transformation nanoparticles facilitates delivery of anti-PD1 antibody and synergizes with antitumor immunotherapy for melanoma

(2019) Ni Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Programmable bacteria induce durable tumor regression and systemic antitumor immunity

(2019) Sreyan Chowdhury et al.   NATURE MEDICINE

Intestinal probiotics E. coli Nissle 1917 as a targeted vehicle for delivery of p53 and Tum-5 to solid tumors for cancer therapy

(2019) Lian He et al.   Journal of Biological Engineering

Combination of Bacterial‐Photothermal Therapy with an Anti‐PD‐1 Peptide Depot for Enhanced Immunity against Advanced Cancer

(2019) Wenfei Chen et al.   ADVANCED FUNCTIONAL MATERIALS

Mild photothermal therapy potentiates anti-PD-L1 treatment for immunologically cold tumors via an all-in-one and all-in-control strategy

(2019) Liping Huang et al.   Nature Communications

Camouflaging bacteria by wrapping with cell membranes

(2019) Zhenping Cao et al.   Nature Communications

Biointerfacial self-assembly generates lipid membrane coated bacteria for enhanced oral delivery and treatment

(2019) Zhenping Cao et al.   Nature Communications

Bacteria-Driven Hypoxia Targeting for Combined Biotherapy and Photothermal Therapy

(2018) Wenfei Chen et al.   ACS Nano

Laser Immunotherapy in Combination with Perdurable PD-1 Blocking for Treatment of Metastatic Tumor

(2018) Lihua Luo et al.   ACS Nano

Combined blockade of IL-6 and PD-1/PD-L1 signaling abrogates mutual regulation of their immunosuppressive effects in the tumor microenvironment

(2018) Hirotake Tsukamoto et al.   CANCER RESEARCH

Bacteria-Mediated Tumor Therapy Utilizing Photothermally-Controlled TNF-α Expression via Oral Administration

(2018) Jin-Xuan Fan et al.   NANO LETTERS

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

Fever-Inspired Immunotherapy Based on Photothermal CpG Nanotherapeutics: The Critical Role of Mild Heat in Regulating Tumor Microenvironment

(2018) Yan Li et al.   Advanced Science

Photosensitizer Micelles Together with IDO Inhibitor Enhance Cancer Photothermal Therapy and Immunotherapy

(2018) Jinrong Peng et al.   Advanced Science

Nanoparticles for Cancer Targeting: Current and Future Directions

(2016) Suryakanta Swain et al.   Current Drug Delivery

Analysis of nanoparticle delivery to tumours

(2016) Stefan Wilhelm et al.   Nature Reviews Materials

Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor- B to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer

(2015) J. Peng et al.   CANCER RESEARCH

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

Non-Cell-Autonomous Tumor Suppression by p53

(2013) Amaia Lujambio et al.   CELL

The Tumor Microenvironment and Strategies to Improve Drug Distribution

(2013) Jasdeep K. Saggar et al.   Frontiers in Oncology

Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer

(2012) Lauren J. Bayne et al.   CANCER CELL

Challenges in design and characterization of ligand-targeted drug delivery systems

(2012) Silvia Muro   JOURNAL OF CONTROLLED RELEASE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Delivery of nanomedicines to extracellular and intracellular compartments of a solid tumor

(2011) Yinghuan Li et al.   ADVANCED DRUG DELIVERY REVIEWS

Motility is critical for effective distribution and accumulation of bacteria in tumor tissue

(2011) Bhushan J. Toley et al.   Integrative Biology

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

(2011) H. Cabral et al.   Nature Nanotechnology

Bacteria-Induced Gap Junctions in Tumors Favor Antigen Cross-Presentation and Antitumor Immunity

(2010) F. Saccheri et al.   Science Translational Medicine

Tumor Invasion of Salmonella enterica Serovar Typhimurium Is Accompanied by Strong Hemorrhage Promoted by TNF-α

(2009) Sara Leschner et al.   PLoS One