Ferroptosis in viral infection: the unexplored possibility

RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrence

(2020) Chao-Chieh Lin et al.   CELL DEATH AND DIFFERENTIATION

A novel coronavirus (2019-nCoV) causing pneumonia-associated respiratory syndrome

(2020) Shibo Jiang et al.   Cellular & Molecular Immunology

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

(2020) Yilong Zou et al.   Nature Chemical Biology

Review of the 2019 novel coronavirus (SARS-CoV-2) based on current evidence

(2020) Lisheng Wang et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients

(2020) Alexey Polonikov   ACS Infectious Diseases

Ferritin: An Inflammatory Player Keeping Iron at the Core of Pathogen-Host Interactions

(2020) Ana C. Moreira et al.   Microorganisms

Identification of the hallmarks of necroptosis and ferroptosis by transmission electron microscopy

(2020) Sanae Miyake et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Iron: Innocent bystander or vicious culprit in COVID-19 pathogenesis?

(2020) Marvin Edeas et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Redox homeostasis maintained by GPX4 facilitates STING activation

(2020) Mutian Jia et al.   NATURE IMMUNOLOGY

From threat to cure: understanding of virus-induced cell death leads to highly immunogenic oncolytic influenza viruses

(2020) Julijan Kabiljo et al.   Cell Death Discovery

Ferroptosis: molecular mechanisms and health implications

(2020) Daolin Tang et al.   CELL RESEARCH

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron oxide nanoparticles based antiviral activity of H1N1 influenza A virus

(2019) Rishikesh Kumar et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

Virus Control of Cell Metabolism for Replication and Evasion of Host Immune Responses

(2019) María Maximina B. Moreno-Altamirano et al.   Frontiers in Cellular and Infection Microbiology

Upregulated expression of the antioxidant sestrin 2 identified by transcriptomic analysis of Japanese encephalitis virus-infected SH-SY5Y neuroblastoma cells

(2019) Michael Carr et al.   VIRUS GENES

Programmed cell death 1 expression and Epstein-Barr virus infection in chronic lymphocytic leukaemia: a prospective cohort study

(2019) Ewelina Grywalska et al.   Cancer Management and Research

Host serum iron modulates dengue virus acquisition by mosquitoes

(2019) Yibin Zhu et al.   Nature Microbiology

The Diversification of Cell Death and Immunity: Memento Mori

(2019) Arnaud J. Legrand et al.   MOLECULAR CELL

African Swine Fever Epidemiology and Control

(2019) Linda K. Dixon et al.   Annual Review of Animal Biosciences

Crossing the Iron Gate: Why and How Transferrin Receptors Mediate Viral Entry

(2018) Marianne Wessling-Resnick   Annual Review of Nutrition

Ferroptosis is a lysosomal cell death process

(2018) Huan Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis

(2018) Rui Kang et al.   Cell Host & Microbe

Alterations in Cellular Iron Metabolism Provide More Therapeutic Opportunities for Cancer

(2018) Liangfu Zhou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel Insights into Cell Entry of Emerging Human Pathogenic Arenaviruses

(2018) Chiara Fedeli et al.   JOURNAL OF MOLECULAR BIOLOGY

Dissecting host cell death programs in the pathogenesis of influenza

(2018) Jeffrey Downey et al.   MICROBES AND INFECTION

Identification of Candidate Iron Transporters From the ZIP/ZnT Gene Families in the Mosquito Aedes aegypti

(2018) Hitoshi Tsujimoto et al.   Frontiers in Physiology

Antiviral effects of ferric ammonium citrate

(2018) Hongbin Wang et al.   Cell Discovery

A novel antiviral inhibits Zika virus infection while increasing intracellular glutathione biosynthesis in distinct cell culture models.

(2018) Mugdha Vasireddi et al.   ANTIVIRAL RESEARCH

Mechanisms of monocyte cell death triggered by dengue virus infection

(2018) Jorge Andrés Castillo et al.   APOPTOSIS

Mitochondrial damage and iron metabolic dysregulation in hepatitis C virus infection

(2018) Keisuke Hino et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lysosomal membrane permeabilization and cell death

(2018) Fengjuan Wang et al.   TRAFFIC

Selenium, Selenoproteins, and Immunity

(2018) Joseph Avery et al.   Nutrients

Down regulation of glutathione and glutamate cysteine ligase in the inflammatory response of macrophages

(2018) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

Activation of Glutathione Peroxidase 4 as a Novel Anti-inflammatory Strategy

(2018) Cong Li et al.   Frontiers in Pharmacology

Temporal changes in glutathione biosynthesis during the lipopolysaccharide-induced inflammatory response of THP-1 macrophages

(2017) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

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(2017) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

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Pneumonitis in Patients Treated With Anti–Programmed Death-1/Programmed Death Ligand 1 Therapy

(2017) Jarushka Naidoo et al.   JOURNAL OF CLINICAL ONCOLOGY

The elemental role of iron in DNA synthesis and repair

(2017) Sergi Puig et al.   Metallomics

Evaluation of the expression level of 12/15 lipoxygenase and the related inflammatory factors (CCL5, CCL3) in respiratory syncytial virus infection in mice model

(2017) Vahid Salimi et al.   MICROBIAL PATHOGENESIS

A study of glutamate levels, NR1, NR2A, NR2B receptors and oxidative stress in rat model of Japanese encephalitis

(2017) Prashant Singh Chauhan et al.   PHYSIOLOGY & BEHAVIOR

Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization

(2017) Antra Zeltina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron availability affects West Nile virus infection in its mosquito vector

(2017) Jean-Bernard Duchemin et al.   Virology Journal

Die Another Day: Inhibition of Cell Death Pathways by Cytomegalovirus

(2017) Wolfram Brune et al.   Viruses-Basel

CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway

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Molecular crosstalk between ferroptosis and apoptosis: emerging role of ER stress-induced p53-independent PUMA expression

(2017) Se Hoon Hong et al.   Oncotarget

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

(2017) Yangchun Xie et al.   Cell Reports

New World Arenavirus Biology

(2017) Nicolás Sarute et al.   Annual Review of Virology

BID links ferroptosis to mitochondrial cell death pathways

(2017) Sandra Neitemeier et al.   Redox Biology

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

FANCD2 protects against bone marrow injury from ferroptosis

(2016) Xinxin Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of ACSL4 as a biomarker and contributor of ferroptosis

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An essential role for functional lysosomes in ferroptosis of cancer cells

(2016) S. Torii et al.   BIOCHEMICAL JOURNAL

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

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(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Oxidative stress favours herpes virus infection in vertebrates: a meta-analysis

(2016) Manrico Sebastiano et al.   Current Zoology

Ferritins: furnishing proteins with iron

(2016) Justin M. Bradley et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Activation ofSAT1engages polyamine metabolism with p53-mediated ferroptotic responses

(2016) Yang Ou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aquatic viruses induce host cell death pathways and its application

(2016) Latif Reshi et al.   VIRUS RESEARCH

Oxidative stress favours herpes virus infection in vertebrates: a meta-analysis

(2016) Manrico Sebastiano et al.   Current Zoology

Cysteine Cathepsin Inhibitors as Anti-Ebola Agents

(2016) Wouter A. van der Linden et al.   ACS Infectious Diseases

Viruses and the Diversity of Cell Death

(2016) Pranav Danthi   Annual Review of Virology

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

(2015) Scott J. Dixon et al.   ACS Chemical Biology

Mitochondrial dynamics and viral infections: A close nexus

(2015) Mohsin Khan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structure–function analysis of NEET proteins uncovers their role as key regulators of iron and ROS homeostasis in health and disease

(2015) Sagi Tamir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Dynamic roles of p53-mediated metabolic activities in ROS-induced stress responses

(2015) Le Jiang et al.   CELL CYCLE

Ferroptosis in p53-dependent oncosuppression and organismal homeostasis

(2015) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Physiological and Pathological Roles of the Mitochondrial Permeability Transition Pore in the Heart

(2015) Jennifer Q. Kwong et al.   Cell Metabolism

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

(2015) Mai Matsushita et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuraminidase of Influenza A Virus Binds Lysosome-Associated Membrane Proteins Directly and Induces Lysosome Rupture

(2015) Xiangwu Ju et al.   JOURNAL OF VIROLOGY

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

HSPB1 as a novel regulator of ferroptotic cancer cell death

(2015) X Sun et al.   ONCOGENE

Ferroptosis is Involved in Acetaminophen Induced Cell Death

(2015) Tamás Lőrincz et al.   PATHOLOGY & ONCOLOGY RESEARCH

Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport

(2015) Tomomi Hashidate-Yoshida et al.   eLife

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

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(2014) C. G. Molteni et al.   FREE RADICAL RESEARCH

Extreme elevation of ferritin and creatine kinase in primary infection with HIV-1

(2014) Zahir Osman Eltahir Babiker et al.   INTERNATIONAL JOURNAL OF STD & AIDS

Targeting xCT, a cystine-glutamate transporter induces apoptosis and tumor regression for KSHV/HIV-associated lymphoma

(2014) Lu Dai et al.   Journal of Hematology & Oncology

EAAT2 (GLT-1; slc1a2) Glutamate Transporters Reconstituted in Liposomes Argues against Heteroexchange Being Substantially Faster than Net Uptake

(2014) Y. Zhou et al.   JOURNAL OF NEUROSCIENCE

Human and Host Species Transferrin Receptor 1 Use by North American Arenaviruses

(2014) M. Zong et al.   JOURNAL OF VIROLOGY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Distinct patterns of hepcidin and iron regulation during HIV-1, HBV, and HCV infections

(2014) A. E. Armitage et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Filoviruses in Bats: Current Knowledge and Future Directions

(2014) Kevin Olival et al.   Viruses-Basel

Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control

(2014) Caiguo Zhang   Protein & Cell

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Glutathione: new roles in redox signaling for an old antioxidant

(2014) Katia Aquilano et al.   Frontiers in Pharmacology

Host iron redistribution as a risk factor for incident tuberculosis in HIV infection: an 11-year retrospective cohort study

(2013) Joann M McDermid et al.   BMC INFECTIOUS DISEASES

Sequestration and Scavenging of Iron in Infection

(2013) Nermi L. Parrow et al.   INFECTION AND IMMUNITY

Lysosomal cell death at a glance

(2013) S. Aits et al.   JOURNAL OF CELL SCIENCE

Inhibitory Effect of Glutathione on Oxidative Liver Injury Induced by Dengue Virus Serotype 2 Infections in Mice

(2013) Juan Wang et al.   PLoS One

Identification of transferrin receptor 1 as a hepatitis C virus entry factor

(2013) D. N. Martin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular bioenergetics, caspase activity and glutathione in murine lungs infected with influenza A virus

(2013) Ahmed R. Alsuwaidi et al.   VIROLOGY

A novel coronavirus capable of lethal human infections: an emerging picture

(2013) Gulfaraz Khan   Virology Journal

The lysosome: from waste bag to potential therapeutic target

(2013) Hanna Appelqvist et al.   Journal of Molecular Cell Biology

Dual Host-Virus Arms Races Shape an Essential Housekeeping Protein

(2013) Ann Demogines et al.   PLOS BIOLOGY

Pathogenesis and clinical implications of HIV-related anemia in 2013

(2013) A. J. Redig et al.   Hematology-American Society of Hematology Education Program

Glutathione synthesis

(2012) Shelly C. Lu   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

ZIP8 Zinc Transporter: Indispensable Role for Both Multiple-Organ Organogenesis and Hematopoiesis In Utero

(2012) Marina Gálvez-Peralta et al.   PLoS One

An Iron Regulatory Gene Signature Predicts Outcome in Breast Cancer

(2011) L. D. Miller et al.   CANCER RESEARCH

Natural Resistance-Associated Macrophage Protein Is a Cellular Receptor for Sindbis Virus in Both Insect and Mammalian Hosts

(2011) Patrick P. Rose et al.   Cell Host & Microbe

Free Radical Lipid Peroxidation: Mechanisms and Analysis

(2011) Huiyong Yin et al.   CHEMICAL REVIEWS

Unveiling the Mechanisms for Decreased Glutathione in Individuals with HIV Infection

(2011) Devin Morris et al.   Clinical & Developmental Immunology

Cell death and infection: A double-edged sword for host and pathogen survival

(2011) Hiroshi Ashida et al.   JOURNAL OF CELL BIOLOGY

Distinct Mechanisms of Ferritin Delivery to Lysosomes in Iron-Depleted and Iron-Replete Cells

(2011) T. Asano et al.   MOLECULAR AND CELLULAR BIOLOGY

Machupo Virus Glycoprotein Determinants for Human Transferrin Receptor 1 Binding and Cell Entry

(2011) Sheli R. Radoshitzky et al.   PLoS One

A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics

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Mitochondrial dysfunction may explain the cardiomyopathy of chronic iron overload

(2010) Xueshan Gao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glutamate and the biology of gliomas

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ZRT/IRT-like Protein 14 (ZIP14) Promotes the Cellular Assimilation of Iron from Transferrin

(2010) Ningning Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron inhibits replication of infectious hepatitis C virus in permissive Huh7.5.1 cells

(2010) Carine Fillebeen et al.   JOURNAL OF HEPATOLOGY

Reduced serum hepcidin levels in patients with chronic hepatitis C

(2009) Domenico Girelli et al.   JOURNAL OF HEPATOLOGY

12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress

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Emergence and pandemic potential of swine-origin H1N1 influenza virus

(2009) Gabriele Neumann et al.   NATURE

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

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Imbalance in oxidant/antioxidant system in different brain regions of rat after the infection of Japanese encephalitis virus

(2009) Sandeep Kumar et al.   NEUROCHEMISTRY INTERNATIONAL

Lysosomes and oxidative stress in aging and apoptosis

(2008) Tino Kurz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

Cell entry by human pathogenic arenaviruses

(2008) Jillian M. Rojek et al.   CELLULAR MICROBIOLOGY

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

The Antiviral Activities of Artemisinin and Artesunate

(2008) Thomas Efferth et al.   CLINICAL INFECTIOUS DISEASES

Role of Xanthine Oxidase Activation and Reduced Glutathione Depletion in Rhinovirus Induction of Inflammation in Respiratory Epithelial Cells

(2008) Alberto Papi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selenoproteins Mediate T Cell Immunity through an Antioxidant Mechanism

(2008) Rajeev K. Shrimali et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different Mechanisms of Cell Entry by Human-Pathogenic Old World and New World Arenaviruses

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Viral infection and iron metabolism

(2008) Hal Drakesmith et al.   NATURE REVIEWS MICROBIOLOGY