Antigen epitope-TLR7/8a conjugate as self-assembled carrier-free nanovaccine for personalized immunotherapy

PolyTLR7/8a-conjugated, antigen-trapping gold nanorods elicit anticancer immunity against abscopal tumors by photothermal therapy-induced in situ vaccination

(2021) Xiang Liu et al.   BIOMATERIALS

Supramolecular co-assembly of self-adjuvanting nanofibrious peptide hydrogel enhances cancer vaccination by activating MyD88-dependent NF-κB signaling pathway without inflammation

(2021) Qi Su et al.   Bioactive Materials

Peptide–TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens

(2020) Geoffrey M. Lynn et al.   NATURE BIOTECHNOLOGY

Redox-Responsive Polycondensate Neoepitope for Enhanced Personalized Cancer Vaccine

(2020) Lixia Wei et al.   ACS Central Science

A bi-adjuvant nanovaccine that potentiates immunogenicity of neoantigen for combination immunotherapy of colorectal cancer

(2020) Qianqian Ni et al.   Science Advances

Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity

(2019) D. Scott Wilson et al.   NATURE MATERIALS

Peptides conjugated to 2-alkoxy-8-oxo-adenine as potential synthetic vaccines triggering TLR7

(2019) Geoffroy P.P. Gential et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Peptide-coordination self-assembly for the precise design of theranostic nanodrugs

(2019) Meiwen Cao et al.   COORDINATION CHEMISTRY REVIEWS

MHC-II neoantigens shape tumour immunity and response to immunotherapy

(2019) Elise Alspach et al.   NATURE

Injectable polypeptide hydrogel for dual-delivery of antigen and TLR3 agonist to modulate dendritic cells in vivo and enhance potent cytotoxic T-lymphocyte response against melanoma

(2018) Huijuan Song et al.   BIOMATERIALS

A facile approach to enhance antigen response for personalized cancer vaccination

(2018) Aileen Weiwei Li et al.   NATURE MATERIALS

Personalized vaccines for cancer immunotherapy

(2018) Ugur Sahin et al.   SCIENCE

Smart Peptide-Based Supramolecular Photodynamic Metallo-Nanodrugs Designed by Multicomponent Coordination Self-Assembly

(2018) Shukun Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12

(2018) Christopher S. Garris et al.   IMMUNITY

Actively personalized vaccination trial for newly diagnosed glioblastoma

(2018) Norbert Hilf et al.   NATURE

Self-assembled PEG–poly(l-valine) hydrogels as promising 3D cell culture scaffolds

(2017) Huijuan Song et al.   Journal of Materials Chemistry B

Efficient Eradication of Established Tumors in Mice with Cationic Liposome-Based Synthetic Long-Peptide Vaccines

(2017) Eleni Maria Varypataki et al.   Cancer Immunology Research

Beyond antigens and adjuvants: formulating future vaccines

(2016) Tyson J. Moyer et al.   JOURNAL OF CLINICAL INVESTIGATION

Designer vaccine nanodiscs for personalized cancer immunotherapy

(2016) Rui Kuai et al.   NATURE MATERIALS

pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation

(2016) Lutz Nuhn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity

(2015) Geoffrey M Lynn et al.   NATURE BIOTECHNOLOGY

Therapeutic vaccines for cancer: an overview of clinical trials

(2014) Ignacio Melero et al.   Nature Reviews Clinical Oncology

Lymphatic-targeted cationic liposomes: A robust vaccine adjuvant for promoting long-term immunological memory

(2014) Ce Wang et al.   VACCINE

Titrating T-Cell Epitopes within Self-Assembled Vaccines Optimizes CD4+ Helper T Cell and Antibody Outputs

(2014) Rebecca R. Pompano et al.   Advanced Healthcare Materials

Dendritic cells process synthetic long peptides better than whole protein, improving antigen presentation and T-cell activation

(2013) Rodney A. Rosalia et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

An update on safety and immunogenicity of vaccines containing emulsion-based adjuvants

(2013) Christopher B Fox et al.   Expert Review of Vaccines

The use of Toll-like receptor 7/8 agonists as vaccine adjuvants

(2013) John P Vasilakos et al.   Expert Review of Vaccines

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Incorporation of d-alanine into poly(ethylene glycol) and l-poly(alanine-co-phenylalanine) block copolymers affects their nanoassemblies and enzymatic degradation

(2013) Min Kyung Joo et al.   Soft Matter

Aptamer-Functionalized, Ultra-Small, Monodisperse Silica Nanoconjugates for Targeted Dual-Modal Imaging of Lymph Nodes with Metastatic Tumors

(2012) Li Tang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dendritic cell activation and T cell priming with adjuvant- and antigen-loaded oxidation-sensitive polymersomes

(2012) Evan A. Scott et al.   BIOMATERIALS

a Totally Synthetic, Self-Assembling, Adjuvant-Free MUC1 Glycopeptide Vaccine for Cancer Therapy

(2012) Zhi-Hua Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Type I interferon response and innate immune sensing of cancer

(2012) Mercedes B. Fuertes et al.   TRENDS IN IMMUNOLOGY

Secretion of adipokines by human adipose tissue in vivo: partitioning between capillary and lymphatic transport

(2011) Norman E. Miller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Vaccine Adjuvants: Putting Innate Immunity to Work

(2010) Robert L. Coffman et al.   IMMUNITY

Structure−Activity Relationships in Human Toll-Like Receptor 7-Active Imidazoquinoline Analogues

(2010) Nikunj M. Shukla et al.   JOURNAL OF MEDICINAL CHEMISTRY

Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia

(2009) Gemma G. Kenter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nanoparticles target distinct dendritic cell populations according to their size

(2008) Vania Manolova et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Superior induction of anti-tumor CTL immunity by extended peptide vaccines involves prolonged, DC-focused antigen presentation

(2008) Martijn S. Bijker et al.   EUROPEAN JOURNAL OF IMMUNOLOGY