Supramolecular co-assembly of self-adjuvanting nanofibrious peptide hydrogel enhances cancer vaccination by activating MyD88-dependent NF-κB signaling pathway without inflammation

Peptide–TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens

(2020) Geoffrey M. Lynn et al.   NATURE BIOTECHNOLOGY

A bi-adjuvant nanovaccine that potentiates immunogenicity of neoantigen for combination immunotherapy of colorectal cancer

(2020) Qianqian Ni et al.   Science Advances

Delivery technologies for cancer immunotherapy

(2019) Rachel S. Riley et al.   NATURE REVIEWS DRUG DISCOVERY

Hierarchically oriented organization in supramolecular peptide crystals

(2019) Chengqian Yuan et al.   Nature Reviews Chemistry

Nucleation and Growth of Amino Acid and Peptide Supramolecular Polymers through Liquid-Liquid Phase Separation

(2019) Chengqian Yuan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

MHC-II neoantigens shape tumour immunity and response to immunotherapy

(2019) Elise Alspach et al.   NATURE

CD4+ T Cell Help Is Required for the Formation of a Cytolytic CD8+ T Cell Subset that Protects against Chronic Infection and Cancer

(2019) Ryan Zander et al.   IMMUNITY

A facile approach to enhance antigen response for personalized cancer vaccination

(2018) Aileen Weiwei Li et al.   NATURE MATERIALS

Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma

(2018) Robert J. Motzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Personalized vaccines for cancer immunotherapy

(2018) Ugur Sahin et al.   SCIENCE

CAR T cell immunotherapy for human cancer

(2018) Carl H. June et al.   SCIENCE

Correlates of adjuvanticity: A review on adjuvants in licensed vaccines

(2018) Giuseppe Del Giudice et al.   SEMINARS IN IMMUNOLOGY

Actively personalized vaccination trial for newly diagnosed glioblastoma

(2018) Norbert Hilf et al.   NATURE

Nano-, micro-, and macroscale drug delivery systems for cancer immunotherapy

(2018) Pingsheng Huang et al.   Acta Biomaterialia

Fine tuning the assembly and gel behaviors of PEGylated polypeptide conjugates by the copolymerization ofl-alanine and γ-benzyl-l-glutamateN-carboxyanhydrides

(2017) Yumin Zhang et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

An immunogenic personal neoantigen vaccine for patients with melanoma

(2017) Patrick A. Ott et al.   NATURE

Efficient Eradication of Established Tumors in Mice with Cationic Liposome-Based Synthetic Long-Peptide Vaccines

(2017) Eleni Maria Varypataki et al.   Cancer Immunology Research

Clinical study of a survivin long peptide vaccine (SurVaxM) in patients with recurrent malignant glioma

(2016) Robert A. Fenstermaker et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Peptide self-assembly: thermodynamics and kinetics

(2016) Juan Wang et al.   CHEMICAL SOCIETY REVIEWS

The administration route is decisive for the ability of the vaccine adjuvant CAF09 to induce antigen-specific CD8 + T-cell responses: The immunological consequences of the biodistribution profile

(2016) Signe Tandrup Schmidt et al.   JOURNAL OF CONTROLLED RELEASE

Designer vaccine nanodiscs for personalized cancer immunotherapy

(2016) Rui Kuai et al.   NATURE MATERIALS

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

Structure-based programming of lymph-node targeting in molecular vaccines

(2014) Haipeng Liu et al.   NATURE

Therapeutic vaccines for cancer: an overview of clinical trials

(2014) Ignacio Melero et al.   Nature Reviews Clinical Oncology

Titrating T-Cell Epitopes within Self-Assembled Vaccines Optimizes CD4+ Helper T Cell and Antibody Outputs

(2014) Rebecca R. Pompano et al.   Advanced Healthcare Materials

Self-Adjuvanting Synthetic Antitumor Vaccines from MUC1 Glycopeptides Conjugated to T-Cell Epitopes from Tetanus Toxoid

(2013) Hui Cai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The use of self-adjuvanting nanofiber vaccines to elicit high-affinity B cell responses to peptide antigens without inflammation

(2013) Jianjun Chen et al.   BIOMATERIALS

An update on safety and immunogenicity of vaccines containing emulsion-based adjuvants

(2013) Christopher B Fox et al.   Expert Review of Vaccines

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Persistent antigen at vaccination sites induces tumor-specific CD8+ T cell sequestration, dysfunction and deletion

(2013) Yared Hailemichael et al.   NATURE MEDICINE

Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

Nivolumab plus Ipilimumab in Advanced Melanoma

(2013) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dipeptides promote folding and peptide binding of MHC class I molecules

(2013) S. K. Saini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Incorporation of d-alanine into poly(ethylene glycol) and l-poly(alanine-co-phenylalanine) block copolymers affects their nanoassemblies and enzymatic degradation

(2013) Min Kyung Joo et al.   Soft Matter

Self-Assembled Peptide Amphiphile Micelles Containing a Cytotoxic T-Cell Epitope Promote a Protective Immune Response In Vivo

(2012) Matthew Black et al.   ADVANCED MATERIALS

Dendritic cell activation and T cell priming with adjuvant- and antigen-loaded oxidation-sensitive polymersomes

(2012) Evan A. Scott et al.   BIOMATERIALS

a Totally Synthetic, Self-Assembling, Adjuvant-Free MUC1 Glycopeptide Vaccine for Cancer Therapy

(2012) Zhi-Hua Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Disparate adjuvant properties among three formulations of “alum”

(2012) Derek W. Cain et al.   VACCINE

Alum adjuvant: some of the tricks of the oldest adjuvant

(2011) M. Kool et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88

(2011) A. Seubert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

(2009) Fiona A. Sharp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A self-assembling peptide acting as an immune adjuvant

(2009) J. S. Rudra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA