Targeted Treatment of Ischemic Stroke by Bioactive Nanoparticle-Derived Reactive Oxygen Species Responsive and Inflammation-Resolving Nanotherapies

Strategies for delivering therapeutics across the blood–brain barrier

(2021) Georg C. Terstappen et al.   NATURE REVIEWS DRUG DISCOVERY

Platelet Membrane Biomimetic Magnetic Nanocarriers for Targeted Delivery and in Situ Generation of Nitric Oxide in Early Ischemic Stroke

(2020) Mingxi Li et al.   ACS Nano

Mesenchymal stem cell-derived magnetic extracellular nanovesicles for targeting and treatment of ischemic stroke

(2020) Han Young Kim et al.   BIOMATERIALS

Novel approaches for the delivery of therapeutics in ischemic stroke

(2020) Saeideh Nozohouri et al.   DRUG DISCOVERY TODAY

Liposomal 9-Aminoacridine for Treatment of Ischemic Stroke: From Drug Discovery to Drug Delivery

(2020) Haojie Wang et al.   NANO LETTERS

Self‐Boosting Catalytic Nanoreactor Integrated with Triggerable Crosslinking Membrane Networks for Initiation of Immunogenic Cell Death by Pyroptosis

(2020) Junjie Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly bioactive zeolitic imidazolate framework-8–capped nanotherapeutics for efficient reversal of reperfusion-induced injury in ischemic stroke

(2020) Lizhen He et al.   Science Advances

Biomimetic and bioresponsive nanotherapies for inflammatory vascular diseases

(2020) Guoyu Yang et al.   Nanomedicine

Distinct Residential and Infiltrated Macrophage Populations and Their Phagocytic Function in Mild and Severe Neonatal Hypoxic-Ischemic Brain Damage

(2020) Yingjun Min et al.   Frontiers in Cellular Neuroscience

Engineering Stem Cell Derived Biomimetic Vesicles for Versatility and Effective Targeted Delivery

(2020) Honghui Wu et al.   ADVANCED FUNCTIONAL MATERIALS

Clinical Effects of Early Edaravone Use in Acute Ischemic Stroke Patients Treated by Endovascular Reperfusion Therapy

(2019) Masaya Enomoto et al.   STROKE

Hollow Prussian Blue Nanozymes Drive Neuroprotection against Ischemic Stroke via Attenuating Oxidative Stress, Counteracting Inflammation, and Suppressing Cell Apoptosis

(2019) Kai Zhang et al.   NANO LETTERS

Neutrophil Membrane-Derived Nanovesicles Alleviate Inflammation To Protect Mouse Brain Injury from Ischemic Stroke

(2019) Xinyue Dong et al.   ACS Nano

Microthrombus‐Targeting Micelles for Neurovascular Remodeling and Enhanced Microcirculatory Perfusion in Acute Ischemic Stroke

(2019) Yifei Lu et al.   ADVANCED MATERIALS

Encapsulation of tissue plasminogen activator in pH-sensitive self-assembled antioxidant nanoparticles for ischemic stroke treatment – Synergistic effect of thrombolysis and antioxidant –

(2019) Ting Mei et al.   BIOMATERIALS

Emerging paradigms in nanotechnology for imaging and treatment of cerebral ischemia

(2019) Sathyasivam Kaviarasi et al.   JOURNAL OF CONTROLLED RELEASE

Sequentially Site-Specific Delivery of Thrombolytics and Neuroprotectant for Enhanced Treatment of Ischemic Stroke

(2019) Jianpei Xu et al.   ACS Nano

Mortality, morbidity, and risk factors in China and its provinces, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2019) Maigeng Zhou et al.   LANCET

Recognition, Intervention, and Monitoring of Neutrophils in Acute Ischemic Stroke

(2019) Chunming Tang et al.   NANO LETTERS

Targeted Drug Delivery to Stroke via Chemotactic Recruitment of Nanoparticles Coated with Membrane of Engineered Neural Stem Cells

(2019) Junning Ma et al.   Small

A Proresolving Peptide Nanotherapy for Site‐Specific Treatment of Inflammatory Bowel Disease by Regulating Proinflammatory Microenvironment and Gut Microbiota

(2019) Chenwen Li et al.   Advanced Science

Nanoparticle-induced neutrophil apoptosis increases survival in sepsis and alleviates neurological damage in stroke

(2019) Can Yang Zhang et al.   Science Advances

Bioinspired Nanosponge for Salvaging Ischemic Stroke via Free Radical Scavenging and Self-Adapted Oxygen Regulating

(2019) Jinjin Shi et al.   NANO LETTERS

Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association

(2019) William J. Powers et al.   STROKE

Bioengineered Boronic Ester Modified Dextran Polymer Nanoparticles as Reactive Oxygen Species Responsive Nanocarrier for Ischemic Stroke Treatment

(2018) Wei Lv et al.   ACS Nano

Simultaneous Blood–Brain Barrier Crossing and Protection for Stroke Treatment Based on Edaravone-Loaded Ceria Nanoparticles

(2018) Qunqun Bao et al.   ACS Nano

Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

(2018) Tian Tian et al.   BIOMATERIALS

Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association

(2018) Emelia J. Benjamin et al.   CIRCULATION

Targeting Reperfusion Injury in the Age of Mechanical Thrombectomy

(2018) Atsushi Mizuma et al.   STROKE

Thrombin-Responsive, Brain-Targeting Nanoparticles for Improved Stroke Therapy

(2018) Xing Guo et al.   ACS Nano

Targeted Therapy of Atherosclerosis by a Broad-Spectrum Reactive Oxygen Species Scavenging Nanoparticle with Intrinsic Anti-inflammatory Activity

(2018) Yuquan Wang et al.   ACS Nano

A Broad-Spectrum ROS-Eliminating Material for Prevention of Inflammation and Drug-Induced Organ Toxicity

(2018) Lanlan Li et al.   Advanced Science

Schaftoside ameliorates oxygen glucose deprivation-induced inflammation associated with the TLR4/Myd88/Drp1-related mitochondrial fission in BV2 microglia cells

(2018) Kecheng Zhou et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

A Targeting Nanotherapy for Abdominal Aortic Aneurysms

(2018) Juan Cheng et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Comprehensive Insights into the Multi-Antioxidative Mechanisms of Melanin Nanoparticles and Their Application To Protect Brain from Injury in Ischemic Stroke

(2017) Yanlan Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stroke

(2017) Graeme J Hankey   LANCET

Microglial Function during Glucose Deprivation: Inflammatory and Neuropsychiatric Implications

(2017) Matthew A. Churchward et al.   MOLECULAR NEUROBIOLOGY

MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1

(2017) Takashi Shichita et al.   NATURE MEDICINE

Neutrophil granulocytes in cerebral ischemia – Evolution from killers to key players

(2017) Jan-Kolja Strecker et al.   NEUROCHEMISTRY INTERNATIONAL

Direct Macromolecular Drug Delivery to Cerebral Ischemia Area using Neutrophil-Mediated Nanoparticles

(2017) Chun Zhang et al.   Theranostics

Nanoparticle-Based Therapeutics for Brain Injury

(2017) Vimala N. Bharadwaj et al.   Advanced Healthcare Materials

Combination of Emricasan with Ponatinib Synergistically Reduces Ischemia/Reperfusion Injury in Rat Brain Through Simultaneous Prevention of Apoptosis and Necroptosis

(2017) Jing Tian et al.   Translational Stroke Research

Complement peptide C3a stimulates neural plasticity after experimental brain ischaemia

(2016) Anna Stokowska et al.   BRAIN

Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation

(2016) Ángel Chamorro et al.   LANCET NEUROLOGY

Resolution of inflammation: a new therapeutic frontier

(2016) James N. Fullerton et al.   NATURE REVIEWS DRUG DISCOVERY

Annexin A1–containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair

(2015) Giovanna Leoni et al.   JOURNAL OF CLINICAL INVESTIGATION

Immune interventions in stroke

(2015) Ying Fu et al.   Nature Reviews Neurology

Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice

(2015) Gabrielle Fredman et al.   Science Translational Medicine

Assessment of Blood–Brain Barrier Disruption in Stroke

(2015) Andrea Kassner et al.   STROKE

Leukocyte Invasion of the Brain After Experimental Intracerebral Hemorrhage in Mice

(2014) Eva Mracsko et al.   STROKE

Microglial Responses after Ischemic Stroke and Intracerebral Hemorrhage

(2013) Roslyn A. Taylor et al.   Clinical & Developmental Immunology

Ceria Nanoparticles that can Protect against Ischemic Stroke

(2012) Chi Kyung Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature

(2012) C. Kleinschnitz et al.   BLOOD

Neuroprotection for Stroke: Current Status and Future Perspectives

(2012) Jens Minnerup et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Dense Poly(Ethylene Glycol) Coating Improves Penetration of Large Polymeric Nanoparticles Within Brain Tissue

(2012) E. A. Nance et al.   Science Translational Medicine

Eligibility for Intravenous Recombinant Tissue-Type Plasminogen Activator Within a Population

(2012) Felipe de los Ríos la Rosa et al.   STROKE

Mouse Model of Middle Cerebral Artery Occlusion

(2011) Terrance Chiang et al.   Jove-Journal of Visualized Experiments

A critical assessment of edaravone acute ischemic stroke efficacy trials: is edaravone an effective neuroprotective therapy?

(2010) Paul A Lapchak   EXPERT OPINION ON PHARMACOTHERAPY

Endocytosis of nanomedicines

(2010) Gaurav Sahay et al.   JOURNAL OF CONTROLLED RELEASE

Phagocytosis of bacteria is enhanced in macrophages undergoing nutrient deprivation

(2009) Wim Martinet et al.   FEBS Journal

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Inflammatory mechanisms in ischemic stroke: therapeutic approaches

(2009) Shaheen E Lakhan et al.   Journal of Translational Medicine

Apoptotic Mechanisms After Cerebral Ischemia

(2009) Brad R.S. Broughton et al.   STROKE

Modulation of Neuro-Inflammation and Vascular Response by Oxidative Stress Following Cerebral Ischemia-Reperfusion Injury

(2008) Peter Crack et al.   CURRENT MEDICINAL CHEMISTRY

Neuroinflammation and microglia: considerations and approaches for neurotoxicity assessment

(2008) Gaylia Jean Harry et al.   Expert Opinion on Drug Metabolism & Toxicology

Blood-brain barrier tight junction permeability and ischemic stroke

(2008) Karin E. Sandoval et al.   NEUROBIOLOGY OF DISEASE