Microthrombus‐Targeting Micelles for Neurovascular Remodeling and Enhanced Microcirculatory Perfusion in Acute Ischemic Stroke

Bioengineered Boronic Ester Modified Dextran Polymer Nanoparticles as Reactive Oxygen Species Responsive Nanocarrier for Ischemic Stroke Treatment

(2018) Wei Lv et al.   ACS Nano

Simultaneous Blood–Brain Barrier Crossing and Protection for Stroke Treatment Based on Edaravone-Loaded Ceria Nanoparticles

(2018) Qunqun Bao et al.   ACS Nano

Blood-Brain Barrier Dysfunction in Ischemic Stroke: Targeting Tight Junctions and Transporters for Vascular Protection

(2018) Wazir Abdullahi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer’s disease and vascular cognitive impairment

(2018) Candice E. Van Skike et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Custom-Made Ceria Nanoparticles Show a Neuroprotective Effect by Modulating Phenotypic Polarization of the Microglia

(2018) Feng Zeng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

cPKCγ-Modulated Sequential Reactivation of mTOR Inhibited Autophagic Flux in Neurons Exposed to Oxygen Glucose Deprivation/Reperfusion

(2018) Rongrong Hua et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke

(2018) Lina R. Nih et al.   NATURE MATERIALS

Advances in stroke pharmacology

(2018) Zhenhua Zhou et al.   PHARMACOLOGY & THERAPEUTICS

Improving Microcirculatory Reperfusion Reduces Parenchymal Oxygen Radical Formation and Provides Neuroprotection

(2018) Aslihan Taskiran-Sag et al.   STROKE

Neuroprotectants in the Era of Reperfusion Therapy

(2018) Ángel Chamorro   Journal of Stroke

Mild hypothermia protects hippocampal neurons against oxygen-glucose deprivation/reperfusion-induced injury by improving lysosomal function and autophagic flux

(2017) Tianen Zhou et al.   EXPERIMENTAL CELL RESEARCH

Stroke

(2017) Graeme J Hankey   LANCET

An environment-dependent transcriptional network specifies human microglia identity

(2017) David Gosselin et al.   SCIENCE

mTORC1 pathway disruption ameliorates brain inflammation following stroke via a shift in microglia phenotype from M1 type to M2 type

(2016) Daojing Li et al.   FASEB JOURNAL

Class I PI3K inhibitor ZSTK474 mediates a shift in microglial/macrophage phenotype and inhibits inflammatory response in mice with cerebral ischemia/reperfusion injury

(2016) Po Wang et al.   Journal of Neuroinflammation

Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation

(2016) Ángel Chamorro et al.   LANCET NEUROLOGY

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis

(2016) Ting Zhang et al.   NATURE MEDICINE

The mTOR signalling cascade: paving new roads to cure neurological disease

(2016) Peter B. Crino   Nature Reviews Neurology

Interleukin-4 Is Essential for Microglia/Macrophage M2 Polarization and Long-Term Recovery After Cerebral Ischemia

(2016) Xiangrong Liu et al.   STROKE

Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation

(2016) Madhulika Tripathi et al.   Cell Death & Disease

Selective modulation of microglia polarization to M2 phenotype for stroke treatment

(2015) Cong-Yuan Xia et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Revisiting Cerebral Postischemic Reperfusion Injury: New Insights in Understanding Reperfusion Failure, Hemorrhage, and Edema

(2015) Jilin Bai et al.   International Journal of Stroke

SOD1 nanozyme salvages ischemic brain by locally protecting cerebral vasculature

(2015) Yuhang Jiang et al.   JOURNAL OF CONTROLLED RELEASE

Attenuation of acute stroke injury in rat brain by minocycline promotes blood–brain barrier remodeling and alternative microglia/macrophage activation during recovery

(2015) Yirong Yang et al.   Journal of Neuroinflammation

Immune interventions in stroke

(2015) Ying Fu et al.   Nature Reviews Neurology

Neuroprotective therapies: Preclinical reproducibility is only part of the problem

(2015) Michael Tymianski   Science Translational Medicine

The Ischemic Environment Drives Microglia and Macrophage Function

(2015) Stefano Fumagalli et al.   Frontiers in Neurology

Hyperbaric oxygen enlarges the area of brain damage in MCAO rats by blocking autophagy via ERK1/2 activation

(2014) Yuxiong Lu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

mTOR Signaling Inhibition Modulates Macrophage/Microglia-Mediated Neuroinflammation and Secondary Injury via Regulatory T Cells after Focal Ischemia

(2014) L. Xie et al.   JOURNAL OF IMMUNOLOGY

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Squalenoyl adenosine nanoparticles provide neuroprotection after stroke and spinal cord injury

(2014) Alice Gaudin et al.   Nature Nanotechnology

Stroke and the Connectome: How Connectivity Guides Therapeutic Intervention

(2014) Gergely Silasi et al.   NEURON

Mannose-Binding Lectin Promotes Local Microvascular Thrombosis After Transient Brain Ischemia in Mice

(2014) Xavier de la Rosa et al.   STROKE

The impact of microglial activation on blood-brain barrier in brain diseases

(2014) Anna Carolina Carvalho da Fonseca et al.   Frontiers in Cellular Neuroscience

TSC1 controls macrophage polarization to prevent inflammatory disease

(2014) Linnan Zhu et al.   Nature Communications

Evaluation of the Protective Potential of Brain Microvascular Endothelial Cell Autophagy on Blood–Brain Barrier Integrity During Experimental Cerebral Ischemia–Reperfusion Injury

(2014) Haiying Li et al.   Translational Stroke Research

Brain-targeting delivery for RNAi neuroprotection against cerebral ischemia reperfusion injury

(2013) Sai An et al.   BIOMATERIALS

Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy

(2013) Michalis Papadakis et al.   NATURE MEDICINE

Pathobiology of injury after stroke: the neurovascular unit and beyond

(2012) Ulrich Dirnagl   Annals of the New York Academy of Sciences

The vascular neural network—a new paradigm in stroke pathophysiology

(2012) John H. Zhang et al.   Nature Reviews Neurology

Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin

(2012) Zhao Zhong Chong et al.   PROGRESS IN NEUROBIOLOGY

The neurovascular unit and combination treatment strategies for stroke

(2012) Li Zhang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

(2012) Dimitrios Davalos et al.   Nature Communications

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Oxidative Stress in Ischemic Brain Damage: Mechanisms of Cell Death and Potential Molecular Targets for Neuroprotection

(2010) Hai Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

Blood-brain barrier tight junction permeability and ischemic stroke

(2008) Karin E. Sandoval et al.   NEUROBIOLOGY OF DISEASE