Self-Protected DNAzyme Walker with a Circular Bulging DNA Shield for Amplified Imaging of miRNAs in Living Cells and Mice

mRNA-Activated Multifunctional DNAzyme Nanotweezer for Intracellular mRNA Sensing and Gene Therapy

(2021) Manman He et al.   ACS Applied Materials & Interfaces

DNAzyme Amplified Aptasensing Platform for Ochratoxin A Detection Using a Personal Glucose Meter

(2021) Songbai Zhang et al.   ACS Applied Materials & Interfaces

Many Birds, One Stone: A Smart Nanodevice for Ratiometric Dual-Spectrum Assay of Intracellular MicroRNA and Multimodal Synergetic Cancer Therapy

(2021) Peng He et al.   ACS Nano

DNAzyme cascade circuits in highly integrated DNA nanomachines for sensitive microRNAs imaging in living cells

(2021) Lu-Ying Duan et al.   BIOSENSORS & BIOELECTRONICS

Programmably tiling rigidified DNA brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of siRNAs

(2021) Chang Xue et al.   Nature Communications

Stimuli-Responsive Autonomous-Motion Molecular Machine for Sensitive Simultaneous Fluorescence Imaging of Intracellular MicroRNAs

(2021) Chang Xue et al.   ANALYTICAL CHEMISTRY

A Synergistic DNA-polydopamine-MnO2 Nanocomplex for Near-Infrared-Light-Powered DNAzyme-Mediated Gene Therapy

(2021) Huaixin Zhao et al.   NANO LETTERS

Endogenous miRNA-Activated DNA Nanomachine for Intracellular miRNA Imaging and Gene Silencing

(2021) Lie Li et al.   ANALYTICAL CHEMISTRY

MicroRNA-Initiated and Intracellular Na+-Fueled DNAzyme Motor for Differentiating Molecular Subtypes of Nonsmall Cell Lung Cancer

(2020) Kun Chen et al.   ANALYTICAL CHEMISTRY

Gold Nanoflares with Computing Function as Smart Diagnostic Automata for Multi-miRNA Patterns in Living Cells

(2020) Lan Liu et al.   ANALYTICAL CHEMISTRY

Periodically Ordered, Nuclease‐Resistant DNA Nanowires Decorated with Cell‐Specific Aptamers as Selective Theranostic Agents

(2020) Chang Xue et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rigidified DNA triangle-protected molecular beacon from endogenous nuclease digestion for monitoring microRNA expression in living cell

(2020) Congcong Li et al.   ACS Sensors

Nonviolent Self-Catabolic DNAzyme Nanosponges for Smart Anticancer Drug Delivery

(2019) Jing Wang et al.   ACS Nano

A microRNA-triggered self-powered DNAzyme walker operating in living cells

(2019) Chang Liu et al.   BIOSENSORS & BIOELECTRONICS

Oriented Tetrahedron-Mediated Protection of Catalytic DNA Molecular-Scale Detector against in Vivo Degradation for Intracellular miRNA Detection

(2019) Congcong Li et al.   ANALYTICAL CHEMISTRY

Y-Shaped Backbone-Rigidified Triangular DNA Scaffold-Directed Stepwise Movement of a DNAzyme Walker for Sensitive MicroRNA Imaging within Living Cells

(2019) Chang Xue et al.   ANALYTICAL CHEMISTRY

A Highly Sensitive Strategy for Fluorescence Imaging of MicroRNA in Living Cells and in Vivo Based on Graphene Oxide-Enhanced Signal Molecules Quenching of Molecular Beacon

(2018) Limin Yang et al.   ACS Applied Materials & Interfaces

Target-Induced Catalytic Assembly of Y-Shaped DNA and Its Application for In Situ Imaging of MicroRNAs

(2018) Chang Xue et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Manufacturing of an electrochemical biosensing platform based on hybrid DNA hydrogel: Taking lung cancer-specific miR-21 as an example

(2018) Shuopeng Liu et al.   BIOSENSORS & BIOELECTRONICS

Poly-adenine-mediated fluorescent spherical nucleic acid probes for live-cell imaging of endogenous tumor-related mRNA

(2018) Dan Zhu et al.   Nanomedicine-Nanotechnology Biology and Medicine

MicroRNA Detection through DNAzyme-Mediated Disintegration of Magnetic Nanoparticle Assemblies

(2018) Bo Tian et al.   ACS Sensors

Dynamic Single Molecular Rulers: Toward Quantitative Detection of MicroRNA-21 in Living Cells

(2018) Mei-Xing Li et al.   ANALYTICAL CHEMISTRY

Branched DNA Junction-Enhanced Isothermal Circular Strand Displacement Polymerization for Intracellular Imaging of MicroRNAs

(2018) Zhe Yang et al.   ANALYTICAL CHEMISTRY

Intracellular self-enhanced rolling circle amplification to image specific miRNAs within tumor cells

(2018) Yan-Ru Chen et al.   SENSORS AND ACTUATORS B-CHEMICAL

Rapid and selective detection of E. coli O157:H7 combining phagomagnetic separation with enzymatic colorimetry

(2017) Yun Zhang et al.   FOOD CHEMISTRY

Optokinetically Encoded Nanoprobe-Based Multiplexing Strategy for MicroRNA Profiling

(2017) Sungi Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A microRNA-initiated DNAzyme motor operating in living cells

(2017) Hanyong Peng et al.   Nature Communications

Real-time visualization of clustering and intracellular transport of gold nanoparticles by correlative imaging

(2017) Mengmeng Liu et al.   Nature Communications

DNAzyme Based Nanomachine for in Situ Detection of MicroRNA in Living Cells

(2017) Jing Liu et al.   ACS Sensors

Biostable L-DNAzyme for Sensing of Metal Ions in Biological Systems

(2016) Liang Cui et al.   ANALYTICAL CHEMISTRY

Aptazyme–Gold Nanoparticle Sensor for Amplified Molecular Probing in Living Cells

(2016) Yanjing Yang et al.   ANALYTICAL CHEMISTRY

Binary System for MicroRNA-Targeted Imaging in Single Cells and Photothermal Cancer Therapy

(2016) Ruo-Can Qian et al.   ANALYTICAL CHEMISTRY

Dual-color encoded DNAzyme nanostructures for multiplexed detection of intracellular metal ions in living cells

(2016) Wenjiao Zhou et al.   BIOSENSORS & BIOELECTRONICS

Blurring the Role of Oligonucleotides: Spherical Nucleic Acids as a Drug Delivery Vehicle

(2016) Xuyu Tan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Translating RNA sequencing into clinical diagnostics: opportunities and challenges

(2016) Sara A. Byron et al.   NATURE REVIEWS GENETICS

DNAzyme Hybridization, Cleavage, Degradation, and Sensing in Undiluted Human Blood Serum

(2015) Wenhu Zhou et al.   ANALYTICAL CHEMISTRY

Signal-off Electrochemiluminescence Biosensor Based on Phi29 DNA Polymerase Mediated Strand Displacement Amplification for MicroRNA Detection

(2015) Anyi Chen et al.   ANALYTICAL CHEMISTRY

DNAzyme-based biosensors and nanodevices

(2015) Liang Gong et al.   CHEMICAL COMMUNICATIONS

MicroRNA-21 controls hTERT via PTEN in human colorectal cancer cell proliferation

(2015) Yang Yang et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

A Nonenzymatic Hairpin DNA Cascade Reaction Provides High Signal Gain of mRNA Imaging inside Live Cells

(2015) Cuichen Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electrostatic Nucleic Acid Nanoassembly Enables Hybridization Chain Reaction in Living Cells for Ultrasensitive mRNA Imaging

(2015) Zhan Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Poly-adenine-based programmable engineering of gold nanoparticles for highly regulated spherical DNAzymes

(2015) Dan Zhu et al.   Nanoscale

Immunomodulatory spherical nucleic acids

(2015) Aleksandar F. Radovic-Moreno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

siRNA-based spherical nucleic acids reverse impaired wound healing in diabetic mice by ganglioside GM3 synthase knockdown

(2015) Pratik S. Randeria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detection of microRNA in Tumor Cells using Exonuclease III and Graphene Oxide-Regulated Signal Amplification

(2014) Rong-Cing Huang et al.   ACS Applied Materials & Interfaces

In Situ Amplification of Intracellular MicroRNA with MNAzyme Nanodevices for Multiplexed Imaging, Logic Operation, and Controlled Drug Release

(2014) Penghui Zhang et al.   ACS Nano

Target-Cell-Specific Fluorescence Silica Nanoprobes for Imaging and Theranostics of Cancer Cells

(2014) Henan Li et al.   ANALYTICAL CHEMISTRY

Highly Sensitive and Selective Strategy for MicroRNA Detection Based on WS2 Nanosheet Mediated Fluorescence Quenching and Duplex-Specific Nuclease Signal Amplification

(2014) Qiang Xi et al.   ANALYTICAL CHEMISTRY

A Highly Sensitive Target-Primed Rolling Circle Amplification (TPRCA) Method for Fluorescent in Situ Hybridization Detection of MicroRNA in Tumor Cells

(2014) Jia Ge et al.   ANALYTICAL CHEMISTRY

Magnetobiosensors Based on Viral Protein p19 for MicroRNA Determination in Cancer Cells and Tissues

(2014) Susana Campuzano et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Toehold-initiated Rolling Circle Amplification for Visualizing Individual MicroRNAs In Situ in Single Cells

(2014) Ruijie Deng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

MicroRNA-21 regulates biological behaviors in papillary thyroid carcinoma by targeting programmed cell death 4

(2014) Jing Zhang et al.   JOURNAL OF SURGICAL RESEARCH

Intracellular Fate of Spherical Nucleic Acid Nanoparticle Conjugates

(2014) Xiaochen A. Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Isothermal amplified detection of DNA and RNA

(2014) Lei Yan et al.   Molecular BioSystems

Engineering interlocking DNA rings with weak physical interactions

(2014) Zai-Sheng Wu et al.   Nature Communications

Ultrasensitive electrochemical detection of cancer-associated circulating microRNA in serum samples based on DNA concatamers

(2013) Cheng-Yi Hong et al.   BIOSENSORS & BIOELECTRONICS

Carbon nanotube-based label-free electrochemical biosensor for sensitive detection of miRNA-24

(2013) Fengye Li et al.   BIOSENSORS & BIOELECTRONICS

Highly selective detection of microRNA based on distance-dependent electrochemiluminescence resonance energy transfer between CdTe nanocrystals and Au nanoclusters

(2013) Yan Cheng et al.   BIOSENSORS & BIOELECTRONICS

RCA Strands as Scaffolds To Create Nanoscale Shapes by a Few Staple Strands

(2013) Yinzhou Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Temperature-Activated Nucleic Acid Nanostructures

(2013) Ke Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A DNAzyme-Gold Nanoparticle Probe for Uranyl Ion in Living Cells

(2013) Peiwen Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism for the endocytosis of spherical nucleic acid nanoparticle conjugates

(2013) C. H. J. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amplified fluorescence detection of mercury(ii) ions (Hg2+) using target-induced DNAzyme cascade with catalytic and molecular beacons

(2012) Lin Qi et al.   ANALYST

A Multicolor Nanoprobe for Detection and Imaging of Tumor-Related mRNAs in Living Cells

(2012) Na Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

One-Step, Multiplexed Fluorescence Detection of microRNAs Based on Duplex-Specific Nuclease Signal Amplification

(2012) Bin-Cheng Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

MicroRNA profiling: approaches and considerations

(2012) Colin C. Pritchard et al.   NATURE REVIEWS GENETICS

Topical delivery of siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation

(2012) Dan Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Graphene oxide-protected DNA probes for multiplex microRNA analysis in complex biological samples based on a cyclic enzymatic amplification method

(2011) Liang Cui et al.   CHEMICAL COMMUNICATIONS

Rapid fluorescence imaging of miRNAs in human cells using templated Staudinger reaction

(2011) Katarzyna Gorska et al.   Chemical Science

Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR (qRT-PCR)

(2010) Evan M. Kroh et al.   METHODS

Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells

(2010) Y. Taniguchi et al.   SCIENCE

Highly Sensitive Determination of microRNA Using Target-Primed and Branched Rolling-Circle Amplification

(2009) Yongqiang Cheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

MicroRNAs: Novel regulators in the hallmarks of human cancer

(2009) Kai Ruan et al.   CANCER LETTERS

Enhanced resistance of DNA nanostructures to enzymatic digestion

(2009) Jung-Won Keum et al.   CHEMICAL COMMUNICATIONS

Biologically Inspired Synthetic Enzymes Made from DNA

(2009) Kenny Schlosser et al.   CHEMISTRY & BIOLOGY

Small-Molecule Inhibitors of MicroRNA miR-21 Function

(2008) Kiranmai Gumireddy et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Enzyme-Based E-DNA Sensor for Sequence-Specific Detection of Femtomolar DNA Targets

(2008) Gang Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polyvalent DNA Nanoparticle Conjugates Stabilize Nucleic Acids

(2008) Dwight S. Seferos et al.   NANO LETTERS

Discriminating single-base difference miRNA expressions using microarray Probe Design Guru (ProDeG)

(2008) Inhan Lee et al.   NUCLEIC ACIDS RESEARCH