Bioinformatics-Guided Expansion and Discovery of Graspetides

Heterologous expression of a cryptic gene cluster from Marinomonas fungiae affords a novel tricyclic peptide marinomonasin

(2021) Issara Kaweewan et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Cellulonodin-2 and Lihuanodin: Lasso Peptides with an Aspartimide Post-Translational Modification

(2021) Li Cao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural Basis for a Dual Function ATP Grasp Ligase That Installs Single and Bicyclic ω-Ester Macrocycles in a New Multicore RiPP Natural Product

(2021) Gengxiang Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Microviridin 1777: A Toxic Chymotrypsin Inhibitor Discovered by a Metabologenomic Approach

(2020) Simon Sieber et al.   JOURNAL OF NATURAL PRODUCTS

Genome Mining Reveals High Topological Diversity of ω-Ester-Containing Peptides and Divergent Evolution of ATP-Grasp Macrocyclases

(2020) Hyunbin Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total synthesis reveals atypical atropisomerism in a small-molecule natural product, tryptorubin A

(2020) Solomon H. Reisberg et al.   SCIENCE

Heterologous expression of a cryptic gene cluster from Grimontia marina affords a novel tricyclic peptide grimoviridin

(2020) Kohta Unno et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family

(2020) Mark C. Walker et al.   BMC GENOMICS

Structure Prediction and Synthesis of Pyridine-Based Macrocyclic Peptide Natural Products

(2020) Graham A. Hudson et al.   ORGANIC LETTERS

RRE-Finder: a Genome-Mining Tool for Class-Independent RiPP Discovery

(2020) Alexander M. Kloosterman et al.   mSystems

Heterologous expression of cryptic biosynthetic gene cluster from Streptomyces prunicolor yields novel bicyclic peptide prunipeptin

(2020) Kohta Unno et al.   MICROBIOLOGICAL RESEARCH

Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease

(2019) Silvia C Bobeica et al.   eLife

Uncovering the unexplored diversity of thioamidated ribosomal peptides in Actinobacteria using the RiPPER genome mining tool

(2019) Javier Santos-Aberturas et al.   NUCLEIC ACIDS RESEARCH

Evidence of Cis/Trans-Isomerization at Pro7/Pro16 in the Lasso Peptide Microcin J25

(2019) Kevin Jeanne Dit Fouque et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Bioinformatic Mapping of Radical S-Adenosylmethionine-Dependent Ribosomally Synthesized and Post-Translationally Modified Peptides Identifies New Cα, Cβ, and Cγ-Linked Thioether-Containing Peptides

(2019) Graham A. Hudson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline

(2019) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

O-Methyltransferase-mediated Incorporation of a β-Amino Acid in Lanthipeptides

(2019) Jeella Z. Acedo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bioinformatic Expansion and Discovery of Thiopeptide Antibiotics

(2018) Christopher J. Schwalen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enzymatic reconstitution of ribosomal peptide backbone thioamidation

(2018) Nilkamal Mahanta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A distributive peptide cyclase processes multiple microviridin core peptides within a single polypeptide substrate

(2018) Yi Zhang et al.   Nature Communications

A topologically distinct modified peptide with multiple bicyclic core motifs expands the diversity of microviridin-like peptides

(2018) Heejin Roh et al.   CHEMBIOCHEM

Enzymatic Reconstitution and Biosynthetic Investigation of the Lasso Peptide Fusilassin

(2018) Adam J. DiCaprio et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

InterPro in 2019: improving coverage, classification and access to protein sequence annotations

(2018) Alex L Mitchell et al.   NUCLEIC ACIDS RESEARCH

Lasso Peptide Benenodin-1 Is a Thermally Actuated [1]Rotaxane Switch

(2017) Chuhan Zong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A new genome-mining tool redefines the lasso peptide biosynthetic landscape

(2017) Jonathan I Tietz et al.   Nature Chemical Biology

PRISM 3: expanded prediction of natural product chemical structures from microbial genomes

(2017) Michael A. Skinnider et al.   NUCLEIC ACIDS RESEARCH

Structural basis for precursor protein–directed ribosomal peptide macrocyclization

(2016) Kunhua Li et al.   Nature Chemical Biology

Enzyme Function Initiative-Enzyme Similarity Tool (EFI-EST): A web tool for generating protein sequence similarity networks

(2015) John A. Gerlt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Cis–Trans Isomerizations of Proline Residues Are Key to Bradykinin Conformations

(2013) Nicholas A. Pierson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

(2012) Paul G. Arnison et al.   NATURAL PRODUCT REPORTS

The ATP-grasp enzymes

(2011) Maria V. Fawaz et al.   BIOORGANIC CHEMISTRY

Leader Peptide and a Membrane Protein Scaffold Guide the Biosynthesis of the Tricyclic Peptide Microviridin

(2011) Annika R. Weiz et al.   CHEMISTRY & BIOLOGY

Amidoligases with ATP-grasp, glutamine synthetase-like and acetyltransferase-like domains: synthesis of novel metabolites and peptide modifications of proteins

(2009) Lakshminarayan M. Iyer et al.   Molecular BioSystems

Ribosomal Synthesis of Tricyclic Depsipeptides in Bloom-Forming Cyanobacteria

(2008) Nadine Ziemert et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Post-translational Modification in Microviridin Biosynthesis

(2008) Benjamin Philmus et al.   CHEMBIOCHEM