Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family

Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease

(2019) Silvia C Bobeica et al.   eLife

Zn-dependent bifunctional proteases are responsible for leader peptide processing of class III lanthipeptides

(2019) Shaoming Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Convergent evolution of the Cys decarboxylases involved in aminovinyl‐cysteine (AviCys) biosynthesis

(2019) Tianlu Mo et al.   FEBS LETTERS

Genome mining for ribosomally synthesised and post-translationally modified peptides (RiPPs) reveals undiscovered bioactive potentials of actinobacteria

(2019) Naghmeh Poorinmohammad et al.   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

Interactive Tree Of Life (iTOL) v4: recent updates and new developments

(2019) Ivica Letunic et al.   NUCLEIC ACIDS RESEARCH

antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline

(2019) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

O-Methyltransferase-mediated Incorporation of a β-Amino Acid in Lanthipeptides

(2019) Jeella Z. Acedo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus

(2019) Sohn G. Kim et al.   NATURE

Roseocin, a novel two‐component lantibiotic from an actinomycete

(2019) Mangal Singh et al.   MOLECULAR MICROBIOLOGY

Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease

(2019) Yi Duan et al.   NATURE

DeepRiPP integrates multiomics data to automate discovery of novel ribosomally synthesized natural products

(2019) Nishanth J. Merwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accessing chemical diversity from the uncultivated symbionts of small marine animals

(2018) Thomas E Smith et al.   Nature Chemical Biology

The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides

(2018) Vincent Wiebach et al.   Nature Chemical Biology

BAGEL4: a user-friendly web server to thoroughly mine RiPPs and bacteriocins

(2018) Auke J van Heel et al.   NUCLEIC ACIDS RESEARCH

The Pfam protein families database in 2019

(2018) Sara El-Gebali et al.   NUCLEIC ACIDS RESEARCH

A new genome-mining tool redefines the lasso peptide biosynthetic landscape

(2017) Jonathan I Tietz et al.   Nature Chemical Biology

Evolutionary radiation of lanthipeptides in marine cyanobacteria

(2017) Andres Cubillos-Ruiz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into enzymatic [4+2]aza-cycloaddition in thiopeptide antibiotic biosynthesis

(2017) Dillon P. Cogan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clustal Omega for making accurate alignments of many protein sequences

(2017) Fabian Sievers et al.   PROTEIN SCIENCE

Discovery and Characterization of Bicereucin, an Unusual d-Amino Acid-Containing Mixed Two-Component Lantibiotic

(2016) Liujie Huo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthetic Timing and Substrate Specificity for the Thiopeptide Thiomuracin

(2016) Zhengan Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genomic charting of ribosomally synthesized natural product chemical space facilitates targeted mining

(2016) Michael A. Skinnider et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thusin, a Novel Two-Component Lantibiotic with Potent Antimicrobial Activity against Several Gram-Positive Pathogens

(2016) Bingyue Xin et al.   Frontiers in Microbiology

HIV Protease Inhibitors Block Streptolysin S Production

(2015) Tucker Maxson et al.   ACS Chemical Biology

Pinensins: The First Antifungal Lantibiotics

(2015) Kathrin I. Mohr et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Distribution and Genetic Diversity of Bacteriocin Gene Clusters in Rumen Microbial Genomes

(2015) Analice C. Azevedo et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Expanded Natural Product Diversity Revealed by Analysis of Lanthipeptide-Like Gene Clusters in Actinobacteria

(2015) Qi Zhang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Enzyme Function Initiative-Enzyme Similarity Tool (EFI-EST): A web tool for generating protein sequence similarity networks

(2015) John A. Gerlt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Chemoenzymatic Synthesis of Thiazolyl Peptide Natural Products Featuring an Enzyme-Catalyzed Formal [4 + 2] Cycloaddition

(2015) Walter J. Wever et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Vitro Biosynthesis of the Core Scaffold of the Thiopeptide Thiomuracin

(2015) Graham A. Hudson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Minimum Information about a Biosynthetic Gene cluster

(2015) Marnix H Medema et al.   Nature Chemical Biology

The Pfam protein families database: towards a more sustainable future

(2015) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes

(2015) Kou-San Ju et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The enterococcal cytolysin synthetase has an unanticipated lipid kinase fold

(2015) Shi-Hui Dong et al.   eLife

Cerecidins, Novel Lantibiotics from Bacillus cereus with Potent Antimicrobial Activity

(2014) Jian Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Genome mining for ribosomally synthesized and post-translationally modified peptides (RiPPs) in anaerobic bacteria

(2014) Anne-Catrin Letzel et al.   BMC GENOMICS

Structure and Biosynthesis of Carnolysin, a Homologue of Enterococcal Cytolysin with d-Amino Acids

(2014) Christopher T. Lohans et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lanthionine synthetase C–like protein 2 (LanCL2) is a novel regulator of Akt

(2014) Min Zeng et al.   MOLECULAR BIOLOGY OF THE CELL

Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB

(2014) Manuel A. Ortega et al.   NATURE

Novel LanT Associated Lantibiotic Clusters Identified by Genome Database Mining

(2014) Mangal Singh et al.   PLoS One

Correction: Improved Lanthipeptide Detection and Prediction for antiSMASH

(2014)   PLoS One

A Glycosylated, Labionin-Containing Lanthipeptide with Marked Antinociceptive Activity

(2013) Marianna Iorio et al.   ACS Chemical Biology

Analysis of Anti-Clostridium difficile Activity of Thuricin CD, Vancomycin, Metronidazole, Ramoplanin, and Actagardine, both Singly and in Paired Combinations

(2013) Harsh Mathur et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Lantibiotic Peptide Labyrinthopeptin A1 Demonstrates Broad Anti-HIV and Anti-HSV Activity with Potential for Microbicidal Applications

(2013) Geoffrey Férir et al.   PLoS One

Biosynthesis of the Class III Lantipeptide Catenulipeptin

(2012) Huan Wang et al.   ACS Chemical Biology

Curvopeptin: A New Lanthionine-Containing Class III Lantibiotic and its Co-substrate Promiscuous Synthetase

(2012) Bartlomiej Krawczyk et al.   CHEMBIOCHEM

Characterization of New Class III Lantibiotics-Erythreapeptin, Avermipeptin and Griseopeptin from Saccharopolyspora erythraea, Streptomyces avermitilis and Streptomyces griseus Demonstrates Stepwise N-Terminal Leader Processing

(2012) Ginka H. Völler et al.   CHEMBIOCHEM

Heterologous production of the lantibiotic Ala(0)actagardine in Escherichia coli

(2012) Yanxiang Shi et al.   CHEMICAL COMMUNICATIONS

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

(2012) Paul G. Arnison et al.   NATURAL PRODUCT REPORTS

Evolution of lanthipeptide synthetases

(2012) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficacy of the New Lantibiotic NAI-107 in Experimental Infections Induced by Multidrug-Resistant Gram-Positive Pathogens

(2011) Daniela Jabés et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Leader Peptide-Directed Processing of Labyrinthopeptin A2 Precursor Peptide by the Modifying Enzyme LabKC

(2011) Wolfgang M. Müller et al.   BIOCHEMISTRY

Heterologous Expression, Biosynthesis, and Mutagenesis of Type II Lantibiotics from Bacillus licheniformis in Escherichia coli

(2011) Tânia Caetano et al.   CHEMISTRY & BIOLOGY

Biosynthesis of the Antimicrobial Peptide Epilancin 15X and Its N-Terminal Lactate

(2011) Juan E. Velásquez et al.   CHEMISTRY & BIOLOGY

Haloduracin α Binds the Peptidoglycan Precursor Lipid II with 2:1 Stoichiometry

(2011) Trent J. Oman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Accelerated Profile HMM Searches

(2011) Sean R. Eddy   PLoS Computational Biology

Labyrinthopeptins: A New Class of Carbacyclic Lantibiotics

(2010) Kathrin Meindl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In Vitro Biosynthesis of the Prepeptide of Type-III Lantibiotic Labyrinthopeptin A2 Including Formation of a CC Bond as a Post-Translational Modification

(2010) Wolfgang M. Müller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Isolation, Structure Elucidation, and Synergistic Antibacterial Activity of a Novel Two-Component Lantibiotic Lichenicidin fromBacillus licheniformisVK21

(2010) Zakhar O. Shenkarev et al.   BIOCHEMISTRY

Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family

(2010) Daniel H Haft et al.   BMC BIOLOGY

FastTree 2 – Approximately Maximum-Likelihood Trees for Large Alignments

(2010) Morgan N. Price et al.   PLoS One

Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria

(2010) B. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of Unique Lanthionine Synthetases Reveals New Mechanistic and Evolutionary Insights

(2010) Yuki Goto et al.   PLOS BIOLOGY

Identification of a Novel Two-Peptide Lantibiotic, Lichenicidin, following Rational Genome Mining for LanM Proteins

(2009) M. Begley et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

MEME SUITE: tools for motif discovery and searching

(2009) T. L. Bailey et al.   NUCLEIC ACIDS RESEARCH

Production of the Novel Two-Peptide Lantibiotic Lichenicidin by Bacillus licheniformis DSM 13

(2009) Jasmin Dischinger et al.   PLoS One

The Importance of the Leader Sequence for Directing Lanthionine Formation in Lacticin 481†

(2008) Gregory C. Patton et al.   BIOCHEMISTRY