Short-term variability in QT interval and ventricular arrhythmias induced by dofetilide are dependent on high-frequency autonomic oscillations

Screening for Acute I Kr Block Is Insufficient to Detect Torsades de Pointes Liability

(2014) Tao Yang et al.   CIRCULATION

The Concise Guide to PHARMACOLOGY 2013/14: Ion Channels

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

hERG Inhibitors with Similar Potency But Different Binding Kinetics Do Not Pose the Same Proarrhythmic Risk: Implications for Drug Safety Assessment

(2013) GIOVANNI Y. DI VEROLI et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

The Lambeth Conventions (II): Guidelines for the study of animal and human ventricular and supraventricular arrhythmias

(2013) Michael J. Curtis et al.   PHARMACOLOGY & THERAPEUTICS

Risperidone, QTc interval prolongation, and torsade de pointes: a systematic review of case reports

(2013) W. Victor R. Vieweg et al.   PSYCHOPHARMACOLOGY

Power spectral analysis of heart rate variability in cynomolgus monkeys in safety pharmacology studies: Comparative study with beagle dogs

(2013) Pascal Champeroux et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Preclinical QT safety assessment: Cross-species comparisons and human translation from an industry consortium

(2013) Henry Holzgrefe et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Catecholaminergic Polymorphic Ventricular Tachycardia

(2012) Antoine Leenhardt et al.   Circulation-Arrhythmia and Electrophysiology

KCNH2 Gene Mutation: A Potential Link Between Epilepsy and Long QT-2 Syndrome

(2012) José J. Zamorano-León et al.   JOURNAL OF NEUROGENETICS

hERG K+ Channels: Structure, Function, and Clinical Significance

(2012) Jamie I. Vandenberg et al.   PHYSIOLOGICAL REVIEWS

hERG subunit composition determines differential drug sensitivity

(2011) N Abi-Gerges et al.   BRITISH JOURNAL OF PHARMACOLOGY

Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes

(2011) L Nalos et al.   BRITISH JOURNAL OF PHARMACOLOGY

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

(2010) JC McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Robust anti-arrhythmic efficacy of verapamil and flunarizine against dofetilide-induced TdP arrhythmias is based upon a shared and a different mode of action

(2010) A Oros et al.   BRITISH JOURNAL OF PHARMACOLOGY

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Interferences of the autonomic nervous system with drug induced QT prolongation: A point to consider in non-clinical safety studies

(2010) Pascal Champeroux et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Relation of Increased Short-Term Variability of QT Interval to Congenital Long-QT Syndrome

(2009) Martin Hinterseer et al.   AMERICAN JOURNAL OF CARDIOLOGY

Dog left ventricular midmyocardial myocytes for assessment of drug-induced delayed repolarization: short-term variability and proarrhythmic potential

(2009) Najah Abi-Gerges et al.   BRITISH JOURNAL OF PHARMACOLOGY

Congenital long QT syndrome presenting with a history of epilepsy: Misdiagnosis or relationship between channelopathies of the heart and brain?

(2009) Chikaya Omichi et al.   EPILEPSIA

A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia

(2009) Stephen J Huffaker et al.   NATURE MEDICINE

The impact of varying autonomic states on the dynamic beat-to-beat QT-RR and QT-TQ interval relationships

(2008) A A Fossa   BRITISH JOURNAL OF PHARMACOLOGY

Combined pharmacological block of IKr and IKs increases short-term QT interval variability and provokes torsades de pointes

(2007) C Lengyel et al.   BRITISH JOURNAL OF PHARMACOLOGY

No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block

(2006) M B Thomsen et al.   BRITISH JOURNAL OF PHARMACOLOGY