Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes

Guide to Receptors and Channels (GRAC), 5th edition

(2011) SPH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Eltrombopag does not affect cardiac repolarization: results from a definitive QTc study in healthy subjects

(2010) Gemma Matthys et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Antimicrobials and the Risk of Torsades de Pointes

(2010) Elisabetta Poluzzi et al.   DRUG SAFETY

Human embryonic stem cell-derived cardiomyocytes: demonstration of a portion of cardiac cells with fairly mature electrical phenotype

(2010) Mari Pekkanen-Mattila et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Late Na+Current Inhibition by Ranolazine Reduces Torsades de Pointes in the Chronic Atrioventricular Block Dog Model

(2010) Gudrun Antoons et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation

(2010) Gary Gintant   PHARMACOLOGY & THERAPEUTICS

Quantified proarrhythmic potential of selected human embryonic stem cell-derived cardiomyocytes

(2010) Malin K.B. Jonsson et al.   Stem Cell Research

The action potential and comparative pharmacology of stem cell-derived human cardiomyocytes

(2010) Shengde Peng et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Moxifloxacin-Induced QT Prolongation and Torsades: An Uncommon Effect of a Common Drug

(2009) Aaref Badshah et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Dog left ventricular midmyocardial myocytes for assessment of drug-induced delayed repolarization: short-term variability and proarrhythmic potential

(2009) Najah Abi-Gerges et al.   BRITISH JOURNAL OF PHARMACOLOGY

Reverse rate dependency is an intrinsic property of canine cardiac preparations

(2009) Tamás Bányász et al.   CARDIOVASCULAR RESEARCH

Assessment of the Ion Channel-blocking Profile of the Novel Combined Ion Channel Blocker AZD1305 and Its Proarrhythmic Potential Versus Dofetilide in the Methoxamine-sensitized Rabbit In Vivo

(2009) Leif Carlsson et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

IKs restricts excessive beat-to-beat variability of repolarization during beta-adrenergic receptor stimulation

(2009) Daniel M. Johnson et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Literature-based evaluation of four ‘hard endpoint’ models for assessing drug-induced torsades de pointes liability

(2008) M A Vos   BRITISH JOURNAL OF PHARMACOLOGY

Beat-to-beat variability of repolarization differentiates the extent of torsadogenic potential of multi ion channel-blockers bepridil and amiodarone

(2008) Akira Takahara et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Plasma protein binding of fluoroquinolones affects antimicrobial activity

(2008) M. Zeitlinger et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The anaesthetised methoxamine-sensitised rabbit model of torsades de pointes

(2008) Leif Carlsson   PHARMACOLOGY & THERAPEUTICS

The canine model with chronic, complete atrio-ventricular block

(2008) Avram Oros et al.   PHARMACOLOGY & THERAPEUTICS

Molecular Signature of Cardiomyocyte Clusters Derived from Human Embryonic Stem Cells

(2008) Jane Synnergren et al.   STEM CELLS

In Vitro Electrophysiological Drug Testing Using Human Embryonic Stem Cell Derived Cardiomyocytes

(2008) Oren Caspi et al.   STEM CELLS AND DEVELOPMENT

No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block

(2006) M B Thomsen et al.   BRITISH JOURNAL OF PHARMACOLOGY