Nucleolus-derived mediators in oncogenic stress response and activation of p53-dependent pathways

Prognostic Significance of Two Dimensional AgNOR Evaluation in Local Advanced Rectal Cancer Treated with Chemoradiotherapy

(2016) Mete Gundog et al.   Asian Pacific Journal of Cancer Prevention

TBMS1 exerts its cytotoxicity in NCI-H460 lung cancer cells through nucleolar stress-induced p53/MDM2-dependent mechanism, a quantitative proteomics study

(2016) Yingying Lin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Nucleation by rRNA Dictates the Precision of Nucleolus Assembly

(2016) Hanieh Falahati et al.   CURRENT BIOLOGY

PERK Integrates Oncogenic Signaling and Cell Survival During Cancer Development

(2016) Yiwen Bu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Phosphatidylinositol 3-Kinase/Akt Mediates Integrin Signaling To Control RNA Polymerase I Transcriptional Activity

(2016) Chuanyue Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

p19Arf is required for the cellular response to chronic DNA damage

(2016) K T Bieging-Rolett et al.   ONCOGENE

PIM1 destabilization activates a p53-dependent response to ribosomal stress in cancer cells

(2016) Vinay Sagar et al.   Oncotarget

Ribosomal protein L4 is a novel regulator of the MDM2-p53 loop

(2016) Xia He et al.   Oncotarget

Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging

(2016) Tongyuan Li et al.   Oncotarget

Cellular discrimination using in vitro Raman micro spectroscopy: the role of the nucleolus

(2015) Z. Farhane et al.   ANALYST

The role of DNA damage responses in p53 biology

(2015) Daniel Speidel   ARCHIVES OF TOXICOLOGY

The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy

(2015) Simone J. Woods et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

TP53 Silencing Bypasses Growth Arrest of BRAFV600E-Induced Lung Tumor Cells in a Two-Switch Model of Lung Tumorigenesis

(2015) A. Shai et al.   CANCER RESEARCH

Dynamic roles of p53-mediated metabolic activities in ROS-induced stress responses

(2015) Le Jiang et al.   CELL CYCLE

Regulatory role of rpL3 in cell response to nucleolar stress induced by Act D in tumor cells lacking functional p53

(2015) Annapina Russo et al.   CELL CYCLE

Ribosome biogenesis dysfunction leads to p53-mediated apoptosis and goblet cell differentiation of mouse intestinal stem/progenitor cells

(2015) A Stedman et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms of p53 degradation

(2015) Chuck C.-K. Chao   CLINICA CHIMICA ACTA

Recent Advances of p53-MDM2 Small Molecule Inhibitors (2011-Present)

(2015) Peng-Cheng Lv et al.   CURRENT MEDICINAL CHEMISTRY

Small-molecule MDM2-p53 inhibitors: recent advances

(2015) Bian Zhang et al.   Future Medicinal Chemistry

DNA damage stress induces the expression of Ribosomal Protein S27a gene in a p53-dependent manner

(2015) Nagisa Nosrati et al.   GENE

Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation

(2015) Jiangge Zheng et al.   GENES & DEVELOPMENT

A localized nucleolar DNA damage response facilitates recruitment of the homology-directed repair machinery independent of cell cycle stage

(2015) Marjolein van Sluis et al.   GENES & DEVELOPMENT

The Wnt Target Protein Peter Pan Defines a Novel p53-independent Nucleolar Stress-Response Pathway

(2015) Astrid S. Pfister et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Higher AgNOR Expression in Metaplastic and Dysplastic Airway Epithelial Cells Predicts the Risk of Developing Lung Cancer in Women Chronically Exposed to Biomass Smoke

(2015) Nandan Kumar Mondal et al.   JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY

Disruption of the 5S RNP–Mdm2 interaction significantly improves the erythroid defect in a mouse model for Diamond-Blackfan anemia

(2015) P Jaako et al.   LEUKEMIA

Human nucleolar protein Nop52 (RRP1/NNP-1) is involved in site 2 cleavage in internal transcribed spacer 1 of pre-rRNAs at early stages of ribosome biogenesis

(2015) H. Yoshikawa et al.   NUCLEIC ACIDS RESEARCH

Direct relationship between the level of p53 stabilization induced by rRNA synthesis-inhibiting drugs and the cell ribosome biogenesis rate

(2015) F Scala et al.   ONCOGENE

The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway

(2015) A Bailly et al.   ONCOGENE

Structural and sequential context of p53: A review of experimental and theoretical evidence

(2015) Taniya Saha et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

RRP12 is a crucial nucleolar protein that regulates p53 activity in osteosarcoma cells

(2015) Young Joon Choi et al.   TUMOR BIOLOGY

Fractal Analysis and the Diagnostic Usefulness of Silver Staining Nucleolar Organizer Regions in Prostate Adenocarcinoma

(2015) Alex Stepan et al.   Analytical Cellular Pathology

Ribosomal proteins: functions beyond the ribosome

(2015) Xiang Zhou et al.   Journal of Molecular Cell Biology

Depletion of the cisplatin targeted HMGB-box factor UBF selectively induces p53-independent apoptotic death in transformed cells

(2015) Nourdine Hamdane et al.   Oncotarget

Perturbation of Ribosome Biogenesis Drives Cells into Senescence through 5S RNP-Mediated p53 Activation

(2015) Kazuho Nishimura et al.   Cell Reports

Mutual Regulation of FOXM1, NPM and ARF Proteins

(2015) Bulbul Pandit et al.   Journal of Cancer

Comparative ultrastructure of CRM1-Nucleolar bodies (CNoBs), Intranucleolar bodies (INBs) and hybrid PML/p62 bodies uncovers new facets of nuclear body dynamic and diversity

(2015) Sylvie Souquere et al.   Nucleus

Comparative ultrastructure of CRM1-Nucleolar bodies (CNoBs), Intranucleolar bodies (INBs) and hybrid PML/p62 bodies uncovers new facets of nuclear body dynamic and diversity

(2015) Sylvie Souquere et al.   Nucleus

MDM2-Mediated Degradation of p14ARF: A Novel Mechanism to Control ARF Levels in Cancer Cells

(2015) Maria Vivo et al.   PLoS One

Ribosomal Proteins RPS11 and RPS20, Two Stress-Response Markers of Glioblastoma Stem Cells, Are Novel Predictors of Poor Prognosis in Glioblastoma Patients

(2015) William H. Yong et al.   PLoS One

AKT regulates NPM dependent ARF localization and p53mut stability in tumors

(2015) Garth Hamilton et al.   Oncotarget

Human rpL3 plays a crucial role in cell response to nucleolar stress induced by 5-FU and L-OHP

(2015) Davide Esposito et al.   Oncotarget

ARF tumor suppression in the nucleolus

(2014) Leonard B. Maggi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Targeting the nucleolus for cancer intervention

(2014) Jaclyn E. Quin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Viruses and the nucleolus: The fatal attraction

(2014) Anna Salvetti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

How Parkinson's disease meets nucleolar stress

(2014) Rosanna Parlato et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The nucleolar size is associated to the methylation status of ribosomal DNA in breast carcinomas

(2014) Maria Giulia Bacalini et al.   BMC CANCER

mTOR inhibitors blunt the p53 response to nucleolar stress by regulating RPL11 and MDM2 levels

(2014) Kaveh M Goudarzi et al.   CANCER BIOLOGY & THERAPY

p53 as a target for the treatment of cancer

(2014) Michael J. Duffy et al.   CANCER TREATMENT REVIEWS

Nucleolar persistence during spermatogenesis of the genusRhodnius(Hemiptera, Triatominae)

(2014) Kaio Cesar Chaboli Alevi et al.   CELL BIOLOGY INTERNATIONAL

Nuclear interactor of ARF and Mdm2 regulates multiple pathways to activate p53

(2014) Sara M Reed et al.   CELL CYCLE

Helicobacter pylori Infection Activates the Akt–Mdm2–p53 Signaling Pathway in Gastric Epithelial Cells

(2014) Xu Shu et al.   DIGESTIVE DISEASES AND SCIENCES

Letters to the Editor: Cardiomyocyte-secreted acetylcholine

(2014) Achilles Pappano   FASEB JOURNAL

p53: The barrier to cancer stem cell formation

(2014) Ronit Aloni-Grinstein et al.   FEBS LETTERS

The cytoplasmic side of p53's oncosuppressive activities

(2014) Anna Comel et al.   FEBS LETTERS

JHDM1B expression regulates ribosome biogenesis and cancer cell growth in a p53 dependent manner

(2014) Marianna Penzo et al.   INTERNATIONAL JOURNAL OF CANCER

Nucleolar Stress Induces Ubiquitination-independent Proteasomal Degradation of PICT1 Protein

(2014) Tomohiko Maehama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small-Molecule Inhibitors of the MDM2–p53 Protein–Protein Interaction (MDM2 Inhibitors) in Clinical Trials for Cancer Treatment

(2014) Yujun Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Combination therapy with p53–MDM2 binding inhibitors for malignancies

(2014) Zegao Jin et al.   MEDICINAL CHEMISTRY RESEARCH

Nucleolar Targeting by Platinum: p53-Independent Apoptosis Follows rRNA Inhibition, Cell-Cycle Arrest, and DNA Compaction

(2014) Erica J. Peterson et al.   MOLECULAR PHARMACEUTICS

Rio1 mediates ATP-dependent final maturation of 40S ribosomal subunits

(2014) Tomasz W. Turowski et al.   NUCLEIC ACIDS RESEARCH

Nucleostemin stabilizes ARF by inhibiting the ubiquitin ligase ULF

(2014) D Lo et al.   ONCOGENE

Physical and functional interaction of the TPL2 kinase with nucleophosmin

(2014) D C Kanellis et al.   ONCOGENE

Nuclear PRAS40 couples the Akt/mTORC1 signaling axis to the RPL11-HDM2-p53 nucleolar stress response pathway

(2014) J J Havel et al.   ONCOGENE

Downregulation of rRNA Transcription Triggers Cell Differentiation

(2014) Yuki Hayashi et al.   PLoS One

A positive feedback loop between EBP2 and c-Myc regulates rDNA transcription, cell proliferation and tumorigenesis

(2014) P Liao et al.   Cell Death & Disease

Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease

(2014) Jeannine Diesch et al.   Cell and Bioscience

ARF and p53 Coordinate Tumor Suppression of an Oncogenic IFN-β-STAT1-ISG15 Signaling Axis

(2014) Jason T. Forys et al.   Cell Reports

NIR is a nucleolar RNA-binding protein that is involved in cell proliferation

(2013) Min Kang et al.   Archives of Biological Sciences

Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis

(2013) Sladana Bursac et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis

(2013) K Evangelou et al.   CELL DEATH AND DIFFERENTIATION

Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation

(2013) Ting Tao et al.   CELL RESEARCH

Another fork in the road—life or death decisions by the tumour suppressor p53

(2013) Luis A Carvajal et al.   EMBO REPORTS

Extensive Post-translational Modification of Active and Inactivated Forms of Endogenous p53

(2013) Caroline J. DeHart et al.   MOLECULAR & CELLULAR PROTEOMICS

Loss of Tumor Suppressor RPL5/RPL11 Does Not Induce Cell Cycle Arrest but Impedes Proliferation Due to Reduced Ribosome Content and Translation Capacity

(2013) T. Teng et al.   MOLECULAR AND CELLULAR BIOLOGY

Differential Effects on ARF Stability by Normal versus Oncogenic Levels of c-Myc Expression

(2013) Delin Chen et al.   MOLECULAR CELL

Regulation of the HDM2-p53 pathway by ribosomal protein L6 in response to ribosomal stress

(2013) Dongmei Bai et al.   NUCLEIC ACIDS RESEARCH

Gradual processing of the ITS1 from the nucleolus to the cytoplasm during synthesis of the human 18S rRNA

(2013) Milena Preti et al.   NUCLEIC ACIDS RESEARCH

Elevated snoRNA biogenesis is essential in breast cancer

(2013) H Su et al.   ONCOGENE

The ribosomal protein S26 regulates p53 activity in response to DNA damage

(2013) D Cui et al.   ONCOGENE

The nucleolus: an emerging target for cancer therapy

(2013) Nadine Hein et al.   TRENDS IN MOLECULAR MEDICINE

5S Ribosomal RNA Is an Essential Component of a Nascent Ribosomal Precursor Complex that Regulates the Hdm2-p53 Checkpoint

(2013) Giulio Donati et al.   Cell Reports

The 5S RNP Couples p53 Homeostasis to Ribosome Biogenesis and Nucleolar Stress

(2013) Katherine E. Sloan et al.   Cell Reports

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

(2012) Megan J. Bywater et al.   CANCER CELL

Immunofluorescent localization of ubiquitin and proteasomes in nucleolar vacuoles of soybean root meristematic cells

(2012) D. Stępiński   EUROPEAN JOURNAL OF HISTOCHEMISTRY

Nucleolar exit of RNF8 and BRCA1 in response to DNA damage

(2012) Marta Guerra-Rebollo et al.   EXPERIMENTAL CELL RESEARCH

Importin 7 and Exportin 1 Link c-Myc and p53 to Regulation of Ribosomal Biogenesis

(2012) Lior Golomb et al.   MOLECULAR CELL

Immobilization of Proteins in the Nucleolus by Ribosomal Intergenic Spacer Noncoding RNA

(2012) Timothy E. Audas et al.   MOLECULAR CELL

Nucleophosmin is essential for c-Myc nucleolar localization and c-Myc-mediated rDNA transcription

(2012) Z Li et al.   ONCOGENE

Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress

(2012) S. Bursac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revisiting the Nucleolus: From Marker to Dynamic Integrator of Cancer Signaling

(2012) D. Ruggero   Science Signaling

Alterations in Nucleolar Structure and Gene Expression Programs in Prostatic Neoplasia Are Driven by the MYC Oncogene

(2011) Cheryl M. Koh et al.   AMERICAN JOURNAL OF PATHOLOGY

mTOR binds to the promoters of RNA polymerase I- and III-transcribed genes

(2011) Chi Kwan Tsang et al.   CELL CYCLE

An intranucleolar body associated with rDNA

(2011) Saskia Hutten et al.   CHROMOSOMA

MdmX Protein Is Essential for Mdm2 Protein-mediated p53 Polyubiquitination

(2011) Xinjiang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleolar proteins with altered expression in leukemic cell lines

(2011) Kaisa J. Teittinen et al.   LEUKEMIA RESEARCH

A Critical Role for Noncoding 5S rRNA in Regulating Mdmx Stability

(2011) Muyang Li et al.   MOLECULAR CELL

It all comes together at the ends: Telomerase structure, function, and biogenesis

(2011) Joshua D. Podlevsky et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11

(2011) Masato Sasaki et al.   NATURE MEDICINE

mTOR signaling regulates the processing of pre-rRNA in human cells

(2011) Valentina Iadevaia et al.   NUCLEIC ACIDS RESEARCH

Nucleophosmin and its complex network: a possible therapeutic target in hematological diseases

(2011) E Colombo et al.   ONCOGENE

Nucleoli: Composition, Function, and Dynamics

(2011) P. Shaw et al.   PLANT PHYSIOLOGY

AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer

(2011) J. C. Chan et al.   Science Signaling

An ARF-Independent c-MYC-Activated Tumor Suppression Pathway Mediated by Ribosomal Protein-Mdm2 Interaction

(2010) Everardo Macias et al.   CANCER CELL

Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth

(2010) Denis Drygin et al.   CANCER RESEARCH

The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor

(2010) J. J. Manfredi   GENES & DEVELOPMENT

The ARF tumor suppressor: Structure, functions and status in cancer

(2010) Peggy Ozenne et al.   INTERNATIONAL JOURNAL OF CANCER

Chemotherapeutic Drugs Inhibit Ribosome Biogenesis at Various Levels

(2010) Kaspar Burger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defects in 18 S or 28 S rRNA Processing Activate the p53 Pathway

(2010) Michael Hölzel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 localizes to intranucleolar regions distinct from the ribosome production compartments

(2010) T. Kruger et al.   JOURNAL OF CELL SCIENCE

The ARF Tumor Suppressor Controls Ribosome Biogenesis by Regulating the RNA Polymerase I Transcription Factor TTF-I

(2010) Frédéric Lessard et al.   MOLECULAR CELL

The Nucleolus under Stress

(2010) Séverine Boulon et al.   MOLECULAR CELL

Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses

(2010) Delin Chen et al.   NATURE

c-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol I availability during granulocyte differentiation

(2010) Gretchen Poortinga et al.   NUCLEIC ACIDS RESEARCH

Ribosome biogenesis surveillance: probing the ribosomal protein-Mdm2-p53 pathway

(2010) C Deisenroth et al.   ONCOGENE

Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability

(2010) L Latonen et al.   ONCOGENE

Nucleolar proteomics and viral infection

(2010) Julian A. Hiscox et al.   PROTEOMICS

The Nucleolus

(2010) T. Pederson   Cold Spring Harbor Perspectives in Biology

Telomere and Telomerase as Targets for Cancer Therapy

(2009) Xiaoping Tian et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Signaling to p53: Ribosomal Proteins Find Their Way

(2009) Yanping Zhang et al.   CANCER CELL

Growth control and ribosome biogenesis

(2009) Harri Lempiäinen et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of nucleolar signalling to p53 through NEDDylation of L11

(2009) Anders Sundqvist et al.   EMBO REPORTS

What the nucleolus says to a tumour pathologist

(2009) Massimo Derenzini et al.   HISTOPATHOLOGY

Pharmacological activation of the p53 pathway in haematological malignancies

(2009) M. N Saha et al.   JOURNAL OF CLINICAL PATHOLOGY

Targeted Molecular Therapy for Neuroblastoma: The ARF/MDM2/p53 Axis

(2009) Eugene Kim et al.   JNCI-Journal of the National Cancer Institute

Organization of the nucleoli of soybean root meristematic cells at different states of their activity

(2009) Dariusz Stępiński   MICRON

A Quantitative Proteomics Analysis of Subcellular Proteome Localization and Changes Induced by DNA Damage

(2009) François-Michel Boisvert et al.   MOLECULAR & CELLULAR PROTEOMICS

Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction

(2009) Stefano Fumagalli et al.   NATURE CELL BIOLOGY

Aberrant mRNA Transcripts and the Nonsense-Mediated Decay Proteins UPF2 and UPF3 Are Enriched in the Arabidopsis Nucleolus

(2009) S. H. Kim et al.   PLANT CELL

Immunodetection of nucleolar proteins and ultrastructure of nucleoli of soybean root meristematic cells treated with chilling stress and after recovery

(2009) Dariusz Stępiński   PROTOPLASMA

MicroRNAs with a nucleolar location

(2009) J. C. Ritland Politz et al.   RNA

p53-Dependent and p53-Independent Activation of Autophagy by ARF

(2008) W. M. Abida et al.   CANCER RESEARCH

Acetylation Is Indispensable for p53 Activation

(2008) Yi Tang et al.   CELL

Pontin is localized in nucleolar fibrillar centers

(2008) Zuzana Cvačková et al.   CHROMOSOMA

siRNA and miRNA processing: new functions for Cajal bodies

(2008) Olga Pontes et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The Perinucleolar Compartment Is Directly Associated with DNA

(2008) John T. Norton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 is localized to a sub-nucleolar compartment after proteasomal inhibition in an energy-dependent manner

(2008) O. Karni-Schmidt et al.   JOURNAL OF CELL SCIENCE

Crosstalk between c-Myc and ribosome in ribosomal biogenesis and cancer

(2008) Mu-Shui Dai et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

NOPdb: Nucleolar Proteome Database--2008 update

(2008) Y. Ahmad et al.   NUCLEIC ACIDS RESEARCH

Nucleophosmin interacts directly with c-Myc and controls c-Myc-induced hyperproliferation and transformation

(2008) Z. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE