Nucleophosmin and its complex network: a possible therapeutic target in hematological diseases

Nucleophosmin/B23 interacts with p21WAF1/CIP1 and contributes to its stability

(2011) Jianyong Xiao et al.   CELL CYCLE

Protein B23/Nucleophosmin/Numatrin Nuclear Dynamics in Relation to Protein Kinase CK2 and Apoptotic Activity in Prostate Cells

(2010) Guixia Wang et al.   BIOCHEMISTRY

CD34+ cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice

(2010) M. P. Martelli et al.   BLOOD

A monoclonal antibody against mutated nucleophosmin 1 for the molecular diagnosis of acute myeloid leukemias

(2010) A. M. Gruszka et al.   BLOOD

Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish

(2010) N. Bolli et al.   BLOOD

Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34- fraction

(2010) D. C. Taussig et al.   BLOOD

The genotype nucleophosmin mutated andFLT3-ITD negative is characterized by high bax/bcl-2 ratio and favourable outcome in acute myeloid leukaemia

(2010) Giovanni Del Poeta et al.   BRITISH JOURNAL OF HAEMATOLOGY

Recruitment of Phosphorylated NPM1 to Sites of DNA Damage through RNF8-Dependent Ubiquitin Conjugates

(2010) A. Koike et al.   CANCER RESEARCH

Arf-induced turnover of the nucleolar nucleophosmin-associated SUMO-2/3 protease Senp3

(2010) Mei-Ling Kuo et al.   CELL CYCLE

DNMT3AMutations in Acute Myeloid Leukemia

(2010) Timothy J. Ley et al.   NEW ENGLAND JOURNAL OF MEDICINE

B23 acts as a nucleolar stress sensor and promotes cell survival through its dynamic interaction with hnRNPU and hnRNPA1

(2010) Z Yao et al.   ONCOGENE

Polo-Like Kinase 2-Dependent Phosphorylation of NPM/B23 on Serine 4 Triggers Centriole Duplication

(2010) Annekatrin Krause et al.   PLoS One

Nucleolar protein B23 has molecular chaperone activities

(2010) Attila Szebeni et al.   PROTEIN SCIENCE

The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model

(2009) K. Cheng et al.   BLOOD

AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biologic, pathologic, immunophenotypic, and prognostic features

(2009) C. Haferlach et al.   BLOOD

Minimal residual disease levels assessed by NPM1 mutation-specific RQ-PCR provide important prognostic information in AML

(2009) S. Schnittger et al.   BLOOD

The impact on outcome of the addition of all-trans retinoic acid to intensive chemotherapy in younger patients with nonacute promyelocytic acute myeloid leukemia: overall results and results in genotypic subgroups defined by mutations in NPM1, FLT3, and CEBPA

(2009) A. K. Burnett et al.   BLOOD

Identification of Nuclear Export Inhibitors with Potent Anticancer Activity In vivo

(2009) S. C. Mutka et al.   CANCER RESEARCH

NPM phosphorylation stimulates Cdk1, overrides G 2 /M checkpoint and increases leukemic blasts in mice

(2009) Wei Du et al.   CARCINOGENESIS

Centromere-Specific Assembly of CENP-A Nucleosomes Is Mediated by HJURP

(2009) Daniel R. Foltz et al.   CELL

Nucleophosmin Blocks Mitochondrial Localization of p53 and Apoptosis

(2009) Sanjit Kumar Dhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleophosmin/B23 Regulates Ubiquitin Dynamics in Nucleoli by Recruiting Deubiquitylating Enzyme USP36

(2009) Akinori Endo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36

(2009) A. Endo et al.   JOURNAL OF CELL SCIENCE

Acetylated NPM1 Localizes in the Nucleoplasm and Regulates Transcriptional Activation of Genes Implicated in Oral Cancer Manifestation

(2009) J. Shandilya et al.   MOLECULAR AND CELLULAR BIOLOGY

Cdk2 and Cdk4 Regulate the Centrosome Cycle and Are Critical Mediators of Centrosome Amplification in p53-Null Cells

(2009) A. M. Adon et al.   MOLECULAR AND CELLULAR BIOLOGY

RNA aptamers interfering with nucleophosmin oligomerization induce apoptosis of cancer cells

(2009) Y Jian et al.   ONCOGENE

SMT3IP1, a nucleolar SUMO-specific protease, deconjugates SUMO-2 from nucleolar and cytoplasmic nucleophosmin

(2008) Tamotsu Nishida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TAT-mediated intracellular delivery of NPM-derived peptide induces apoptosis in leukemic cells and suppresses leukemogenesis in mice

(2008) Y. Zhou et al.   BLOOD

Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouse

(2008) P. Sportoletti et al.   BLOOD

MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia

(2008) M. Jongen-Lavrencic et al.   BLOOD

Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation

(2008) W Lee Kraus   CURRENT OPINION IN CELL BIOLOGY

The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing

(2008) Markus Haindl et al.   EMBO REPORTS

Nucleophosmin is required for chromosome congression, proper mitotic spindle formation, and kinetochore-microtubule attachment in HeLa cells

(2008) Mohammed Abdullahel Amin et al.   FEBS LETTERS

Late relapse of acute myeloid leukemia with mutated NPM1 after eight years: evidence of NPM1 mutation stability

(2008) G. Meloni et al.   HAEMATOLOGICA

NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: a comparative analysis of 2562 patients with acute myeloid leukemia

(2008) B. Falini et al.   HAEMATOLOGICA

Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia. Results from the AMLSG Trial AML HD98B

(2008) R. F. Schlenk et al.   HAEMATOLOGICA

Structural Consequences of Nucleophosmin Mutations in Acute Myeloid Leukemia

(2008) Charles G. Grummitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7γ

(2008) Paola Bonetti et al.   JOURNAL OF CELL BIOLOGY

Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases

(2008) Chawon Yun et al.   JOURNAL OF CELL BIOLOGY

Transvection mediated by the translocated cyclin D1 locus in mantle cell lymphoma

(2008) Hui Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nucleophosmin Interacts with HEXIM1 and Regulates RNA Polymerase II Transcription

(2008) Meera Gurumurthy et al.   JOURNAL OF MOLECULAR BIOLOGY

NPM1 mutations in therapy-related acute myeloid leukemia with uncharacteristic features

(2008) M T Andersen et al.   LEUKEMIA

Therapy-related acute myeloid leukaemia with mutated NPM1: treatment induced or de novo in origin?

(2008) B Falini   LEUKEMIA

Increase sensitivity to chemotherapeutical agents and cytoplasmatic interaction between NPM leukemic mutant and NF-κB in AML carrying NPM1 mutations

(2008) D Cilloni et al.   LEUKEMIA

A dose-dependent tug of war involving the NPM1 leukaemic mutant, nucleophosmin and ARF

(2008) N Bolli et al.   LEUKEMIA

Posttranscriptional Regulation of Chicken ccn2 Gene Expression by Nucleophosmin/B23 during Chondrocyte Differentiation

(2008) Y. Mukudai et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcription Regulation of the rRNA Gene by a Multifunctional Nucleolar Protein, B23/Nucleophosmin, through Its Histone Chaperone Activity

(2008) K. Murano et al.   MOLECULAR AND CELLULAR BIOLOGY

Nucleophosmin Serves as a Rate-Limiting Nuclear Export Chaperone for the Mammalian Ribosome

(2008) L. B. Maggi et al.   MOLECULAR AND CELLULAR BIOLOGY

A ribosomal protein L23-nucleophosmin circuit coordinates Miz1 function with cell growth

(2008) Michael Wanzel et al.   NATURE CELL BIOLOGY

Mutations and Treatment Outcome in Cytogenetically Normal Acute Myeloid Leukemia

(2008) Richard F. Schlenk et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nucleophosmin interacts directly with c-Myc and controls c-Myc-induced hyperproliferation and transformation

(2008) Z. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Akt interacts with B23/NPM and protects it from proteolytic cleavage, enhancing cell survival

(2008) S. B. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin

(2008) R. Garzon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA