Article
Microbiology
Zuhua Yu, Yingying Zhao, Ke Ding, Lei He, Chengshui Liao, Jing Li, Songbiao Chen, Ke Shang, Jian Chen, Chuan Yu, Chunjie Zhang, Yinju Li, Shaohui Wang, Yanyan Jia
Summary: This study demonstrated that Listeria monocytogenes (LM) exhibits antitumor effects by inducing autophagy, and the combination of LM and the autophagy inhibitor chloroquine (CQ) enhances the antitumor activity of LM both in vitro and in vivo.
Article
Cell Biology
Ayelen Valko, Sebastian Perez-Pandolfo, Eleonora Sorianello, Andreas Brech, Pablo Wappner, Mariana Melani
Summary: Hypoxia induces autophagy in Drosophila melanogaster, which is essential for adaptation and survival. The process involves a bona fide autophagic response with waves of autophagosome formation and maturation, and is induced cell autonomously in different tissues. Autophagy under hypoxic conditions can be studied using D. melanogaster as a model organism, offering insights into its role in hypoxia-associated pathologies and developmentally regulated processes.
Article
Cell Biology
Yao Huang, Yanhai Feng, Lin Cui, Lei Yang, Qiong Zhang, Junhui Zhang, Xupin Jiang, Xingyue Zhang, Yanling Lv, Jie-Zhi Jia, Dong-Xia Zhang, Yue-Sheng Huang
Summary: The study revealed the relationship between autophagy and necroptosis, showing that LC3 mediated interactions play a crucial role in regulating the necrotic process in cardiomyocytes. Disruption of autophagic flux led to increased necroptosis activation, while intact autophagic flux helped reduce necroptosis occurrence.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Ophthalmology
Flavia Plastino, Alvaro Santana-Garrido, Noemi Anna Pesce, Monica Aronsson, Emma Lardner, Alfonso Mate, Anders Kvanta, Carmen Maria Vazquez, Helder Andre
Summary: Our study demonstrates that Echinomycin can inhibit HIF-mediated angiogenesis in vitro and reduce vascular lesions in a mouse model of CNV, suggesting potential implications for the treatment of neovascular age-related macular degeneration in patients.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Shuning He, Mark W. Zimmerman, Hillary M. Layden, Alla Berezovskaya, Julia Etchin, Megan W. Martel, Grace Thurston, Chang-Bin Jing, Ellen van Rooijen, Charles K. Kaufman, Scott J. Rodig, Leonard I. Zon, E. Elizabeth Patton, Marc R. Mansour, A. Thomas Look
Summary: Loss of the NF1 tumor suppressor gene can lead to aggressive melanomas with a high risk of treatment failure. This study established a zebrafish model of NF1-mutant melanomas harboring PTEN loss and demonstrated that mTOR inhibitors and a three-drug combination can potently induce apoptosis in NF1/PTEN-deficient melanoma cells, supporting the need for early-stage clinical trials in patients.
Article
Biochemistry & Molecular Biology
Nienke Visser, Harm Jan Lourens, Gerwin Huls, Edwin Bremer, Valerie R. Wiersma
Summary: The study found that the activity of the autophagy pathway did not differ between AraC-Res AML cells and parental AraC-sensitive AML cells, and treatment with autophagy inhibitors did not re-sensitize AraC-Res AML cells to AraC. However, in parental AraC-sensitive AML cells, treatment with AraC activated autophagy and a combination with autophagy inhibitors significantly reduced cell viability. Additionally, the combination of these drugs resulted in the highest level of cell death in patient-derived AML samples, although not additive.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Juan Wang, Liyan Qiu
Summary: In this study, a pH-responsive drug-induced self-assembled nanovesicle was developed based on an amphiphilic copolymer for the simultaneous delivery of doxorubicin hydrochloride (DOX·HCl) and chloroquine (CQ). The nanovesicle exhibited excellent delivery performance both in vitro and in vivo, and CQ enhanced the efficacy of DOX·HCl by inhibiting autophagy. Therefore, this study provides a promising strategy for precise combination therapy.
Article
Oncology
Zeynep Eroglu, Y. Ann Chen, Inna Smalley, Jiannong Li, Joseph K. Markowitz, Andrew S. Brohl, Leticia Tetteh, Hayley Taylor, Vernon K. Sondak, Nikhil I. Khushalani, Keiran S. M. Smalley
Summary: In this study, the efficacy and safety of vemurafenib and cobimetinib in combination with different doses of the HSP90 inhibitor XL888 for the treatment of advanced melanoma were explored. The study found that this combination therapy showed activity in some patients, but also had significant toxicity.
Article
Chemistry, Medicinal
Hafiz Muhammad Ahmad Javaid, Hwayeon Lim, Sooim Shin, Joo Young Huh
Summary: Chloroquine inhibits autophagy and affects mitochondrial quality and respiratory function. Additionally, chloroquine treatment induces oxidative stress, apoptosis, and metabolic dysregulation.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Cell Biology
Zhifei Xu, Zezheng Pan, Ying Jin, Zizheng Gao, Feng Jiang, Huangxi Fu, Xueqin Chen, Xiaochen Zhang, Hao Yan, Xiaochun Yang, Bo Yang, Qiaojun He, Peihua Luo
Summary: This study revealed a novel mechanism for Crizotinib-induced cardiotoxicity, demonstrating that reviving the autophagy flux can reverse cardiomyocyte damage and mitochondrial injury, with metformin potentially serving as a therapeutic approach for Crizotinib-induced cardiotoxicity.
Article
Biochemistry & Molecular Biology
Celia Fourrier, Valerie Bryksin, Kathryn Hattersley, Leanne K. Hein, Julien Bensalem, Timothy J. Sargeant
Summary: Measurement of autophagic flux in the brain remains a challenging research topic, with current methods not fully effective in capturing autophagic activity in this specific tissue. More research is needed to find a suitable drug for this purpose.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Simone Degan, Brian L. May, Yingai J. Jin, Manel Ben Hammoda, Huiying Sun, Guoqiang Zhang, Yan Wang, Detlev Erdmann, Warren Warren, Jennifer Y. Zhang
Summary: In preclinical experiments on melanoma, combination therapy with chloroquine (CQ) and MEK inhibitor trametinib (TRA) slowed down the growth of melanoma. This combination treatment decreased cancer cell proliferation and also reduced immune cell infiltration.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dorota Gil, Piotr Laidler, Marta Zarzycka, Joanna Dulinska-Litewka
Summary: The study highlights the dual role of autophagy in cancer and the potential therapeutic implications. Knockdown of ILK was found to promote autophagy through AMPK activation, leading to suppression of melanoma cell growth and induction of apoptosis. Combining CQ and siILK showed stronger antitumor effects, possibly through synergistic inhibition of protein synthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Jun-yi Zhu, Xiaohu Huang, Yulong Fu, Yin Wang, Pan Zheng, Yang Liu, Zhe Han
Summary: This study investigates the role of oncogenic Ras proteins in acute myeloid leukemia using a Drosophila model. Through genetic and drug screens, the researchers identify candidate genes and a potential targeted drug, echinomycin, that can attenuate oncogenic Ras-induced cancer phenotypes. The study suggests that inhibiting the hypoxia pathway could be an effective treatment approach.
DISEASE MODELS & MECHANISMS
(2022)
Article
Chemistry, Medicinal
Afnan H. El-Gowily, Samah A. Loutfy, Ehab M. M. Ali, Tarek M. Mohamed, Mohammed A. Mansour
Summary: The combination therapy of chloroquine and/or tioconazole with doxorubicin showed significant efficacy in inhibiting tumor proliferation and inducing apoptosis in MCF-7 breast cancer cells. The therapy also targeted the redox balance of cancer cells and modulated autophagy and PI3K/AKT/mTOR pathways to sensitize cancer cells to doxorubicin treatment, suggesting a potential for combating its toxicity.
Article
Biotechnology & Applied Microbiology
Wenyuan Yin, Charles W. Kimbrough, Jorge G. Gomez-Gutierrez, Christopher T. Burns, Phillip Chuong, William E. Grizzle, Lacey R. McNally
JOURNAL OF NANOBIOTECHNOLOGY
(2015)
Article
Oncology
Shanice V. Hudson, Justin S. Huang, Wenyuan Yin, Sabrin Albeituni, Jamie Rush, Anil Khanal, Jun Yan, Brian P. Ceresa, Hermann B. Frieboes, Lacey R. McNally
Article
Neurosciences
Michael D. Weber, Daniel B. McKim, Anzela Niraula, Kristina G. Witcher, Wenyuan Yin, Carly G. Sobol, Yufen Wang, Caroline M. Sawicki, John F. Sheridan, Jonathan P. Godbout
BIOLOGICAL PSYCHIATRY
(2019)
Article
Cell Biology
Daniel B. Mckim, Wenyuan Yin, Yufen Wang, Steve W. Cole, Jonathan P. Godbout, John F. Sheridan
Article
Immunology
Wenyuan Yin, Natalie R. Gallagher, Caroline M. Sawicki, Daniel B. McKim, Jonathan P. Godbout, John F. Sheridan
BRAIN BEHAVIOR AND IMMUNITY
(2019)
Article
Neurosciences
Wenyuan Yin, Samuel P. Swanson, Rebecca G. Biltz, Ethan J. Goodman, Natalie R. Gallagher, John F. Sheridan, Jonathan P. Godbout
Summary: Chronic stress can lead to psychiatric disorders, including anxiety. Repeated Social Defeat (RSD) in mice was found to increase the accumulation of inflammatory monocytes in brain blood vessels, activate endothelial cells, and enhance anxiety-like behavior. Research revealed that activated endothelial cells have specific RNA profiles associated with cell adhesion, IL-1 and prostaglandin signaling, HPA axis activation, and anxiety.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Hermann B. Frieboes, Justin S. Huang, Wenyuan C. Yin, Lacey R. McNally
JOURNAL OF THE PANCREAS
(2014)
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)