Association of Gut Microbiome Dysbiosis with Neurodegeneration: Can Gut Microbe-Modifying Diet Prevent or Alleviate the Symptoms of Neurodegenerative Diseases?

Associations among Dietary Omega-3 Polyunsaturated Fatty Acids, the Gut Microbiota, and Intestinal Immunity

(2021) Yawei Fu et al.   MEDIATORS OF INFLAMMATION

The gut microbiome modulates the protective association between a Mediterranean diet and cardiometabolic disease risk

(2021) Dong D. Wang et al.   NATURE MEDICINE

The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition

(2021) Wing K. Man et al.   Nature Communications

Meta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation

(2021) Stefano Romano et al.   npj Parkinsons Disease

Lipopolysaccharide Evaluation in Peritoneal Dialysis Patients with Peritonitis

(2020) Sabrina Milan Manani et al.   BLOOD PURIFICATION

The progress of gut microbiome research related to brain disorders

(2020) Sibo Zhu et al.   Journal of Neuroinflammation

Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice

(2020) Collin Challis et al.   NATURE NEUROSCIENCE

Polyphenol supplementation benefits human health via gut microbiota: A systematic review via meta-analysis

(2020) Guiling Ma et al.   Journal of Functional Foods

Effect of Caloric Restriction on BMI, Gut Microbiota, and Blood Amino Acid Levels in Non-Obese Adults

(2020) Hua Zou et al.   Nutrients

A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice

(2020) Timothy R Sampson et al.   eLife

Interventional Influence of the Intestinal Microbiome Through Dietary Intervention and Bowel Cleansing Might Improve Motor Symptoms in Parkinson’s Disease

(2020) Tobias Hegelmaier et al.   Cells

The effect of antibiotics on the gut microbiome: a metagenomics analysis of microbial shift and gut antibiotic resistance in antibiotic treated mice

(2020) Lei Xu et al.   BMC GENOMICS

Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells

(2020) Qi Yan Ang et al.   CELL

The Antioxidants Glutathione, Ascorbic Acid and Uric Acid Maintain Butyrate Production by Human Gut Clostridia in The Presence of Oxygen In Vitro

(2020) Matthieu Million et al.   Scientific Reports

Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer’s transgenic mice

(2020) Hemraj B. Dodiya et al.   Scientific Reports

Sodium Butyrate Exacerbates Parkinson’s Disease by Aggravating Neuroinflammation and Colonic Inflammation in MPTP-Induced Mice Model

(2020) Chen-Meng Qiao et al.   NEUROCHEMICAL RESEARCH

The Paradox of HIV Blood–Brain Barrier Penetrance and Antiretroviral Drug Delivery Deficiencies

(2020) Olivia Osborne et al.   TRENDS IN NEUROSCIENCES

Human Gut-Microbiota Interaction in Neurodegenerative Disorders and Current Engineered Tools for Its Modeling

(2020) Florencia Andrea Ceppa et al.   Frontiers in Cellular and Infection Microbiology

Gut Microbiota: Implications in Alzheimer’s Disease

(2020) Yixi He et al.   Journal of Clinical Medicine

Different effects of constitutive and induced microbiota modulation on microglia in a mouse model of Alzheimer’s disease

(2020) Charlotte Mezö et al.   Acta Neuropathologica Communications

Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications

(2020) Marta Pajares et al.   Cells

White matter and neurological disorders

(2020) Han-Gyu Bae et al.   ARCHIVES OF PHARMACAL RESEARCH

Increased Intestinal Permeability in Older Subjects Impacts the Beneficial Effects of Dietary Polyphenols by Modulating Their Bioavailability

(2020) Nicole Hidalgo-Liberona et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside

(2020) David Sulzer et al.   npj Parkinsons Disease

Extra-virgin olive oil and the gut-brain axis: influence on gut microbiota, mucosal immunity, and cardiometabolic and cognitive health

(2020) Jasmine F Millman et al.   NUTRITION REVIEWS

Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson’s disease

(2019) Sebastiaan P. van Kessel et al.   Nature Communications

Role of Ketogenic Diets in Neurodegenerative Diseases (Alzheimer’s Disease and Parkinson’s Disease)

(2019) Dariusz Włodarek   Nutrients

Effects of oral butyrate supplementation on inflammatory potential of circulating peripheral blood mononuclear cells in healthy and obese males

(2019) Maartje C. P. Cleophas et al.   Scientific Reports

Alzheimer’s Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway

(2019) John P. Haran et al.   mBio

Fecal metabolite of a gnotobiotic mouse transplanted with gut microbiota from a patient with Alzheimer’s disease

(2019) Yusuke Fujii et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Fecal microbiota transplantation to treat Parkinsonʼs disease with constipation

(2019) Hongli Huang et al.   MEDICINE

TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease

(2019) Ana Griciuc et al.   NEURON

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease

(2019) Sangjune Kim et al.   NEURON

Severe Constipation in Parkinson's Disease and in Parkinsonisms: Prevalence and Affecting Factors

(2019) Giuseppe Frazzitta et al.   Frontiers in Neurology

Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model

(2019) Jared D. Hoffman et al.   PLoS One

Prion-Like Mechanisms in Parkinson’s Disease

(2019) Jiangnan Ma et al.   Frontiers in Neuroscience

Antibiotic exposure and risk of Parkinson's disease in Finland: A nationwide case‐control study

(2019) Tuomas H. Mertsalmi et al.   MOVEMENT DISORDERS

Calorie restriction slows age-related microbiota changes in an Alzheimer’s disease model in female mice

(2019) Laura M. Cox et al.   Scientific Reports

Co-stimulation with IL-1β and TNF-α induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system

(2019) Tanja Hyvärinen et al.   Scientific Reports

Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8+ T-cell memory development

(2019) Huafeng Zhang et al.   NATURE CELL BIOLOGY

Exercise, diet and stress as modulators of gut microbiota: Implications for neurodegenerative diseases

(2019) Carolina Gubert et al.   NEUROBIOLOGY OF DISEASE

Microbiome changes: an indicator of Parkinson’s disease?

(2019) Caroline Haikal et al.   Translational Neurodegeneration

Dietary fiber intervention on gut microbiota composition in healthy adults: a systematic review and meta-analysis

(2018) Daniel So et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Clinical and metabolic response to probiotic administration in people with Parkinson's disease: A randomized, double-blind, placebo-controlled trial

(2018) Omid Reza Tamtaji et al.   CLINICAL NUTRITION

Gut Microbiota is Altered in Patients with Alzheimer’s Disease

(2018) Zhen-Qian Zhuang et al.   JOURNAL OF ALZHEIMERS DISEASE

Gastrointestinal nervous system α-synuclein as a potential biomarker of Parkinson disease

(2018) Fudong Yan et al.   MEDICINE

Tau-targeting therapies for Alzheimer disease

(2018) Erin E. Congdon et al.   Nature Reviews Neurology

Trial of Solanezumab for Mild Dementia Due to Alzheimer’s Disease

(2018) Lawrence S. Honig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice

(2018) David Ma et al.   Scientific Reports

Parkinson disease with constipation: clinical features and relevant factors

(2018) Qiu-Jin Yu et al.   Scientific Reports

The Neuroprotection of Low-Dose Morphine in Cellular and Animal Models of Parkinson’s Disease Through Ameliorating Endoplasmic Reticulum (ER) Stress and Activating Autophagy

(2018) Bing Wang et al.   Frontiers in Molecular Neuroscience

Immunosuppressants and risk of Parkinson disease

(2018) Brad A. Racette et al.   Annals of Clinical and Translational Neurology

Probiotic Supplementation in Patients with Alzheimer’s Dementia – An Explorative Intervention Study

(2018) Friedrich Leblhuber et al.   Current Alzheimer Research

Does Severity of Alzheimer's Disease Contribute to Its Responsiveness to Modifying Gut Microbiota? A Double Blind Clinical Trial

(2018) Azadeh Agahi et al.   Frontiers in Neurology

Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome

(2018) Dora Abraham et al.   EXPERIMENTAL GERONTOLOGY

Calorie restriction and its impact on gut microbial composition and global metabolism

(2018) Xiaojiao Zheng et al.   Frontiers of Medicine

The effect of the stress hormone cortisol on the metatranscriptome of the oral microbiome

(2018) Ana E. Duran-Pinedo et al.   npj Biofilms and Microbiomes

Why do trials for Alzheimer’s disease drugs keep failing? A discontinued drug perspective for 2010-2015

(2017) Dev Mehta et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Activated microglia induce the production of reactive oxygen species and promote apoptosis of co-cultured retinal microvascular pericytes

(2017) Xinyi Ding et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Sodium butyrate exerts protective effect against Parkinson's disease in mice via stimulation of glucagon like peptide-1

(2017) Jiaming Liu et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Diet, Gut Microbiota, and Vitamins D + A in Multiple Sclerosis

(2017) Paolo Riccio et al.   Neurotherapeutics

Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naïve Parkinson’s disease patients

(2017) J. R. Bedarf et al.   Genome Medicine

The role of microbial amyloid in neurodegeneration

(2017) Robert P. Friedland et al.   PLoS Pathogens

Insights into Butyrate Production in a Controlled Fermentation System via Gene Predictions

(2017) S. Esquivel-Elizondo et al.   mSystems

Adherence to Mediterranean diet and risk of developing cognitive disorders: An updated systematic review and meta-analysis of prospective cohort studies

(2017) Lei Wu et al.   Scientific Reports

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

(2017) T. Harach et al.   Scientific Reports

Butyrate-producing bacteria supplemented in vitro to Crohn’s disease patient microbiota increased butyrate production and enhanced intestinal epithelial barrier integrity

(2017) Annelies Geirnaert et al.   Scientific Reports

Vascular contributions to cognitive impairment, clinical Alzheimer's disease, and dementia in older persons

(2016) A. Kapasi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility

(2016) Mahesh S. Desai et al.   CELL

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Association between Parkinson's Disease andHelicobacter Pylori

(2016) Gülşah Çamcı et al.   Journal of Clinical Neurology

Functional analysis of the relationship between intestinal microbiota and the expression of hepatic genes and pathways during the course of liver regeneration

(2016) Hui-Xin Liu et al.   JOURNAL OF HEPATOLOGY

Diet-induced extinctions in the gut microbiota compound over generations

(2016) Erica D. Sonnenburg et al.   NATURE

Probiotics and prebiotic fiber for constipation associated with Parkinson disease

(2016) Michela Barichella et al.   NEUROLOGY

Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

(2016) Alexandra Zhernakova et al.   SCIENCE

Selective pressure against horizontally acquired prokaryotic genes as a driving force of plastid evolution

(2016) Briardo Llorente et al.   Scientific Reports

Environmental risk factors for dementia: a systematic review

(2016) Lewis O. J. Killin et al.   BMC Geriatrics

Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate

(2016) Sama F Sleiman et al.   eLife

Nonmotor gastrointestinal disorders in older patients with Parkinson’s disease: is there hope?

(2016) Doina Georgescu et al.   Clinical Interventions in Aging

Increased Gut Redox and Depletion of Anaerobic and Methanogenic Prokaryotes in Severe Acute Malnutrition

(2016) Matthieu Million et al.   Scientific Reports

Individual aggregates of amyloid beta induce temporary calcium influx through the cell membrane of neuronal cells

(2016) Anna Drews et al.   Scientific Reports

Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril

(2016) Changyoun Kim et al.   Scientific Reports

Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans

(2016) Shu G. Chen et al.   Scientific Reports

The genetic landscape of Alzheimer disease: clinical implications and perspectives

(2015) Caroline Van Cauwenberghe et al.   GENETICS IN MEDICINE

Ketogenic diet in a patient with congenital hyperinsulinism: a novel approach to prevent brain damage

(2015) Arianna Maiorana et al.   Orphanet Journal of Rare Diseases

Role of the normal gut microbiota

(2015) Sai Manasa Jandhyala   WORLD JOURNAL OF GASTROENTEROLOGY

Lactobacillus fermentumNS9 restores the antibiotic induced physiological and psychological abnormalities in rats

(2015) T. Wang et al.   Beneficial Microbes

Structure and Function of Bacterial Biofilms by Solid-State NMR

(2015) Courtney Reichhardt et al.   BIOPHYSICAL JOURNAL

Inflammation and the Blood Microvascular System

(2015) Jordan S. Pober et al.   Cold Spring Harbor Perspectives in Biology

The overlap between vascular disease and Alzheimer’s disease - lessons from pathology

(2014) Johannes Attems et al.   BMC Medicine

Gut microbiota are related to Parkinson's disease and clinical phenotype

(2014) Filip Scheperjans et al.   MOVEMENT DISORDERS

Structural changes in the gut microbiome of constipated patients

(2014) Lixin Zhu et al.   PHYSIOLOGICAL GENOMICS

PD-L1 Expression Induced by the 2009 Pandemic Influenza A(H1N1) Virus Impairs the Human T Cell Response

(2013) Nuriban Valero-Pacheco et al.   Clinical & Developmental Immunology

A Dietary Regimen of Caloric Restriction or Pharmacological Activation of SIRT1 to Delay the Onset of Neurodegeneration

(2013) J. Graff et al.   JOURNAL OF NEUROSCIENCE

Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies

(2013) Gaia Codolo et al.   PLoS One

Structural modulation of gut microbiota in life-long calorie-restricted mice

(2013) Chenhong Zhang et al.   Nature Communications

Parkinsonism Due to Mutations in PINK1, Parkin, and DJ-1 and Oxidative Stress and Mitochondrial Pathways

(2013) M. R. Cookson   Cold Spring Harbor Perspectives in Medicine

Long-term impact of systemic bacterial infection on the cerebral vasculature and microglia

(2012) Ursula Püntener et al.   Journal of Neuroinflammation

Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease

(2011) Christopher B. Forsyth et al.   PLoS One

Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

(2011) G. D. Wu et al.   SCIENCE

Prebiotic evaluation of cocoa-derived flavanols in healthy humans by using a randomized, controlled, double-blind, crossover intervention study

(2010) Xenofon Tzounis et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Caloric Restriction in Humans: Impact on Physiological, Psychological, and Behavioral Outcomes

(2010) Leanne M. Redman et al.   ANTIOXIDANTS & REDOX SIGNALING

Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update

(2010) Karen Nuytemans et al.   HUMAN MUTATION

Influenza caused epidemic encephalitis (encephalitis lethargica): The circumstantial evidence and a challenge to the nonbelievers

(2010) C.P. Maurizi   MEDICAL HYPOTHESES

Microglial activation and chronic neurodegeneration

(2010) Melinda E. Lull et al.   Neurotherapeutics

Prevalence of smell loss in Parkinson's disease – A multicenter study

(2009) A. Haehner et al.   PARKINSONISM & RELATED DISORDERS

Viral parkinsonism

(2008) Haeman Jang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

(2008) Peter J. Turnbaugh et al.   Cell Host & Microbe

Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin

(2008) Inmaculada Cuchillo-Ibanez et al.   FASEB JOURNAL

Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease

(2008) Vanessa Brochard et al.   JOURNAL OF CLINICAL INVESTIGATION