Acrylonitrile Derivatives against Trypanosoma cruzi: In Vitro Activity and Programmed Cell Death Study

Synergistic effect and ultrastructural changes in Trypanosoma cruzi caused by isoobtusilactone A in short exposure of time

(2021) Júlio Menta de Almeida et al.   PLoS One

High Throughput Approaches to Unravel the Mechanism of Action of a New Vanadium-Based Compound against Trypanosoma cruzi

(2020) M. Florencia Mosquillo et al.   BIOINORGANIC CHEMISTRY AND APPLICATIONS

Integrated molecular signalling involving mitochondrial dysfunction and alteration of cell metabolism during antitumoral properties of tyrosine kinase inhibitors in cancer

(2020) María A. Rodríguez-Hernández et al.   Redox Biology

Antikinetoplastid Activity of Indolocarbazoles from Streptomyces sanyensis

(2020) Luis Cartuche et al.   Biomolecules

Sesquiterpenoids and flavonoids from Inula viscosa induce programmed cell death in kinetoplastids

(2020) Ikrame Zeouk et al.   BIOMEDICINE & PHARMACOTHERAPY

Pulmonary and systemic toxicity in rats following inhalation exposure of 3-D printer emissions from acrylonitrile butadiene styrene (ABS) filament

(2020) Mariana T. Farcas et al.   INHALATION TOXICOLOGY

Proteomic changes in Trypanosoma cruzi epimastigotes treated with the proapoptotic compound PAC-1

(2020) Emanuella de Castro Andreassa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Cell death pathways in pathogenic trypanosomatids: lessons of (over)kill

(2019) Rubem Figueiredo Sadok Menna-Barreto   Cell Death & Disease

Repurposing strategies for Chagas disease therapy: the effect of imatinib and derivatives against Trypanosoma cruzi

(2019) M. R. Simões-Silva et al.   PARASITOLOGY

Structure-Based Virtual Screening and In Vitro Evaluation of New Trypanosoma cruzi Cruzain Inhibitors

(2019) Verónica Herrera-Mayorga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chagas disease as example of a reemerging parasite

(2019) Jeannette Guarner   SEMINARS IN DIAGNOSTIC PATHOLOGY

Antiparasitic effect of (−)-α-bisabolol against Trypanosoma cruzi Y strain forms

(2019) Ramon R.P.P.B. de Menezes et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Susceptibility to the acute toxicity of acrylonitrile in streptozotocin-induced diabetic rats: protective effect of phenethyl isothiocyanate, a phytochemical CYP2E1 inhibitor

(2019) Fang Li et al.   DRUG AND CHEMICAL TOXICOLOGY

Screening of the pathogen box for the identification of anti-Acanthamoeba agents

(2019) Ines Sifaoui et al.   EXPERIMENTAL PARASITOLOGY

Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement

(2019) Juliana C. Gomes et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Catalytic hydrocyanation of activated terminal alkynes

(2019) David Tejedor et al.   CHEMISTRY-A EUROPEAN JOURNAL

The crucial role of macromolecular engineering, drug encapsulation and dilution on the thermoresponsiveness of UCST diblock copolymer nanoparticles used for hyperthermia

(2019) Alexandre Bordat et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Withanolides from Withania aristata as Antikinetoplastid Agents through Induction of Programmed Cell Death

(2019) López-Arencibia et al.   Pathogens

Antiprotozoal activities of marine polyether triterpenoids

(2019) Ana R. Díaz-Marrero et al.   BIOORGANIC CHEMISTRY

Novel benzimidazole-acrylonitrile hybrids and their derivatives: Design, synthesis and antimycobacterial activity

(2019) Mustafa Mert Sirim et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

In vitro activity of 1H-phenalen-1-one derivatives against Leishmania spp. and evidence of programmed cell death

(2019) Atteneri López-Arencibia et al.   Parasites & Vectors

Current trends in the pharmacological management of Chagas disease

(2019) Vanessa Ribeiro et al.   International Journal for Parasitology-Drugs and Drug Resistance

Technological innovation strategies for the specific treatment of Chagas disease based on Benznidazole

(2018) Leslie Raphael de Moura Ferraz et al.   ACTA TROPICA

Synthesis and pharmacological evaluation of 2,3-diphenyl acrylonitriles-bearing halogen as selective anticancer agents

(2018) Jia-Jun Li et al.   Chemical Biology & Drug Design

Chagas disease

(2018) José A Pérez-Molina et al.   LANCET

Programmed Cell Death, from a Cancer Perspective: An Overview

(2018) Abhay P. Mishra et al.   Molecular Diagnosis & Therapy

Acute and chronic toxicity effects of acrylonitrile to the juvenile marine flounder Paralichthys olivaceus

(2018) Pengfei Lin et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study

(2018) Daiane Dias Ferreira et al.   JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES

Antibacterial activity and mechanism of action of the benzazole acrylonitrile-based compounds: In vitro , spectroscopic, and docking studies

(2017) Shaikha S. AlNeyadi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Acaricidal Activity, and Structure–Activity Relationships of Pyrazolyl Acrylonitrile Derivatives

(2016) Haibo Yu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Resveratrol Reverses Functional Chagas Heart Disease in Mice

(2016) Glaucia Vilar-Pereira et al.   PLoS Pathogens

The importance of the multidisciplinary approach to deal with the new epidemiological scenario of Chagas disease (global health)

(2015) Maria-Jesus Pinazo et al.   ACTA TROPICA

Differential protection of pre- versus post-treatment with curcumin, Trolox, and N -acetylcysteine against acrylonitrile-induced cytotoxicity in primary rat astrocytes

(2015) Bai Yu et al.   NEUROTOXICOLOGY

Randomized Trial of Posaconazole and Benznidazole for Chronic Chagas' Disease

(2014) Israel Molina et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nifurtimox therapy for Chagas disease does not cause hypersensitivity reactions in patients with such previous adverse reactions during benznidazole treatment

(2013) José A. Pérez-Molina et al.   ACTA TROPICA

Treatment of Chagas' disease with itraconazole: electrocardiographic and parasitological conditions after 20 years of follow-up

(2013) W. Apt et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Fexinidazole: A Potential New Drug Candidate for Chagas Disease

(2012) Maria Terezinha Bahia et al.   PLoS Neglected Tropical Diseases

Chagas disease

(2010) Anis Rassi et al.   LANCET

Chagas disease in Spain, the United States and other non-endemic countries

(2009) Joaquim Gascon et al.   ACTA TROPICA

Natural programmed cell death inT. cruziepimastigotes maintained in axenic cultures

(2008) V. Jimenez et al.   JOURNAL OF CELLULAR BIOCHEMISTRY