Programmed PPAR-α downregulation induces inflammaging by suppressing fatty acid catabolism in monocytes

Monocytes present age‐related changes in phospholipid concentration and decreased energy metabolism

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Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging?

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Lipid droplet‐dependent fatty acid metabolism controls the immune suppressive phenotype of tumor‐associated macrophages

(2019) Hao Wu et al.   EMBO Molecular Medicine

Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis

(2018) Ajit S. Divakaruni et al.   Cell Metabolism

Aging impairs mitochondrial respiratory capacity in classical monocytes

(2018) Brandt D. Pence et al.   EXPERIMENTAL GERONTOLOGY

Lipid Droplets as Immune Modulators in Myeloid Cells

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The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence

(2018) Siew-Min Ong et al.   Cell Death & Disease

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

(2018) Luigi Ferrucci et al.   Nature Reviews Cardiology

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

(2018) Claudio Franceschi et al.   Nature Reviews Endocrinology

Cytosolic lipid excess-induced mitochondrial dysfunction is the cause or effect of high fat diet-induced skeletal muscle insulin resistance: a molecular insight

(2018) Baishali Alok Jana et al.   MOLECULAR BIOLOGY REPORTS

Dynamics and functions of lipid droplets

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(2017) Dylan Thomas et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Saturated fatty acids trigger TLR4-mediated inflammatory response

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Macrophage fatty acid oxidation and its roles in macrophage polarization and fatty acid-induced inflammation

(2016) Dmitry Namgaladze et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipid droplets in leukocytes: Organelles linked to inflammatory responses

(2016) Rossana C.N. Melo et al.   EXPERIMENTAL CELL RESEARCH

TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity

(2016) Alicja Puchta et al.   PLoS Pathogens

Age-associated changes in long-chain fatty acid profile during healthy aging promote pro-inflammatory monocyte polarization via PPARγ

(2015) Chathyan Pararasa et al.   AGING CELL

Inhibition of macrophage fatty acid β-oxidation exacerbates palmitate-induced inflammatory and endoplasmic reticulum stress responses

(2014) Dmitry Namgaladze et al.   DIABETOLOGIA

Simplified production and concentration of lentiviral vectors to achieve high transduction in primary human T cells

(2013) Adam P Cribbs et al.   BMC BIOTECHNOLOGY

Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy

(2013) Myriam N. Bouchlaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Critical Role of Metabolic Pathways in Aging

(2012) N. Barzilai et al.   DIABETES

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Advanced Age Impairs Macrophage Polarization

(2011) Shegufta Mahbub et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Food restriction improves glucose and lipid metabolism through Sirt1 expression: A study using a new rat model with obesity and severe hypertension

(2011) Kumiko Takemori et al.   LIFE SCIENCES

Not Just Fat: The Structure and Function of the Lipid Droplet

(2011) T. Fujimoto et al.   Cold Spring Harbor Perspectives in Biology

Depletion of macrophages in mice results in higher dengue virus titers and highlights the role of macrophages for virus control

(2009) Katja Fink et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis

(2009) K. A. Mattos et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

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