GRP78 Overexpression Triggers PINK1-IP3R-Mediated Neuroprotective Mitophagy

Endogenous Mechanisms of Neuroprotection: To Boost or Not to Be

(2021) Sara Marmolejo-Martínez-Artesero et al.   Cells

ER stress sensor, glucose regulatory protein 78 (GRP78) regulates redox status in pancreatic cancer thereby maintaining “stemness”

(2019) Patricia Dauer et al.   Cell Death & Disease

Mitophagy and Neuroprotection

(2019) Guofeng Lou et al.   TRENDS IN MOLECULAR MEDICINE

Post-translational Modifications of Key Machinery in the Control of Mitophagy

(2019) Liming Wang et al.   TRENDS IN BIOCHEMICAL SCIENCES

The regulation of autophagy by calcium signals: Do we have a consensus?

(2018) Martin D. Bootman et al.   CELL CALCIUM

PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1–Parkin-mediated mitophagy

(2018) Liming Wang et al.   CELL RESEARCH

ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells

(2018) Ching-Wen Chang et al.   Cell Death & Disease

ATG5 overexpression is neuroprotective and attenuates cytoskeletal and vesicle-trafficking alterations in axotomized motoneurons

(2018) Tatiana Leiva-Rodríguez et al.   Cell Death & Disease

SIRT1 activation with neuroheal is neuroprotective but SIRT2 inhibition with AK7 is detrimental for disconnected motoneurons

(2018) David Romeo-Guitart et al.   Cell Death & Disease

Neuroprotective Drug for Nerve Trauma Revealed Using Artificial Intelligence

(2018) David Romeo-Guitart et al.   Scientific Reports

The PERK Arm of the Unfolded Protein Response Regulates Mitochondrial Morphology during Acute Endoplasmic Reticulum Stress

(2018) Justine Lebeau et al.   Cell Reports

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

(2018) Konstantinos Palikaras et al.   NATURE CELL BIOLOGY

No Parkin Zone: Mitophagy without Parkin

(2018) Elodie Villa et al.   TRENDS IN CELL BIOLOGY

Association of the IP3R to STIM1 provides a reduced intraluminal calcium microenvironment, resulting in enhanced store-operated calcium entry

(2018) Alicia Sampieri et al.   Scientific Reports

Disease‐associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria

(2018) Nadia Cummins et al.   EMBO JOURNAL

Modulation of Mitochondrial Dynamics in Neurodegenerative Diseases: An Insight Into Prion Diseases

(2018) Ting Zhu et al.   Frontiers in Aging Neuroscience

Pink1 interacts with α-synuclein and abrogates α-synuclein-induced neurotoxicity by activating autophagy

(2017) Jia Liu et al.   Cell Death & Disease

Boosted Regeneration and Reduced Denervated Muscle Atrophy by NeuroHeal in a Pre-clinical Model of Lumbar Root Avulsion with Delayed Reimplantation

(2017) David Romeo-Guitart et al.   Scientific Reports

GRP78 at the Centre of the Stage in Cancer and Neuroprotection

(2017) Caty Casas   Frontiers in Neuroscience

Modulation of SQSTM1/p62 activity by N-terminal arginylation of the endoplasmic reticulum chaperone HSPA5/GRP78/BiP

(2016) Hyunjoo Cha-Molstad et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Membrane Protein Quantity Control at the Endoplasmic Reticulum

(2016) Ignat Printsev et al.   JOURNAL OF MEMBRANE BIOLOGY

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

Deciphering the Molecular Signals of PINK1/Parkin Mitophagy

(2016) Thanh N. Nguyen et al.   TRENDS IN CELL BIOLOGY

GRP78 is implicated in the modulation of tumor aerobic glycolysis by promoting autophagic degradation of IKKβ

(2015) Zongwei Li et al.   CELLULAR SIGNALLING

Targeted siRNA Screens Identify ER-to-Mitochondrial Calcium Exchange in Autophagy and Mitophagy Responses in RPE1 Cells

(2015) Thomas MacVicar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding

(2015) Hyunjoo Cha-Molstad et al.   NATURE CELL BIOLOGY

Molecular chaperone GRP78 enhances aggresome delivery to autophagosomes to promote drug resistance in multiple myeloma

(2015) Mohamed A.Y. Abdel Malek et al.   Oncotarget

Network-based proteomic approaches reveal the neurodegenerative, neuroprotective and pain-related mechanisms involved after retrograde axonal damage

(2015) Caty Casas et al.   Scientific Reports

Development of a Rapid, Robust, and Universal PicoGreen-Based Method to Titer Adeno-Associated Vectors

(2015) Jose Piedra et al.   Human Gene Therapy Methods

Protein moonlighting: a new factor in biology and medicine

(2014) Brian Henderson et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Raf/MEK/ERK can regulate cellular levels of LC3B and SQSTM1/p62 at expression levels

(2014) Jin-Hwan Kim et al.   EXPERIMENTAL CELL RESEARCH

Neuronal Bioenergetics and Acute Mitochondrial Dysfunction: A Clue to Understanding the Central Nervous System Side Effects of Efavirenz

(2014) Haryes A. Funes et al.   JOURNAL OF INFECTIOUS DISEASES

Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis

(2014) Alban Ordureau et al.   MOLECULAR CELL

Wallerian degeneration: an emerging axon death pathway linking injury and disease

(2014) Laura Conforti et al.   NATURE REVIEWS NEUROSCIENCE

Oxidative Stress-Induced Signaling Pathways Implicated in the Pathogenesis of Parkinson’s Disease

(2014) Georgia S. Gaki et al.   NEUROMOLECULAR MEDICINE

Late-Onset of Spinal Neurodegeneration in Knock-In Mice Expressing a Mutant BiP

(2014) Hisayo Jin et al.   PLoS One

De-Differentiation Confers Multidrug Resistance Via Noncanonical PERK-Nrf2 Signaling

(2014) Catherine A. Del Vecchio et al.   PLOS BIOLOGY

Intrathecal administration of IGF-I by AAVrh10 improves sensory and motor deficits in a mouse model of diabetic neuropathy

(2014) Judit Homs et al.   Molecular Therapy-Methods & Clinical Development

Heat shock 70 kDa protein 5/glucose-regulated protein 78 “AMP”ing up autophagy

(2012) Katherine L. Cook et al.   Autophagy

Endoplasmic Reticulum Stress Impairs Insulin Signaling through Mitochondrial Damage in SH-SY5Y Cells

(2012) Hyun-Jung Koo et al.   NEUROSIGNALS

Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting

(2011) Min Ni et al.   BIOCHEMICAL JOURNAL

Autophagy and BiP level decrease are early key events in retrograde degeneration of motoneurons

(2011) C Penas et al.   CELL DEATH AND DIFFERENTIATION

Cripto Regulates Hematopoietic Stem Cells as a Hypoxic-Niche-Related Factor through Cell Surface Receptor GRP78

(2011) Kenichi Miharada et al.   Cell Stem Cell

Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage

(2011) U. Shirendeb et al.   HUMAN MOLECULAR GENETICS

Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress

(2011) R. Bravo et al.   JOURNAL OF CELL SCIENCE

Sigma Receptor Agonist 2-(4-Morpholinethyl)1 Phenylcyclohexanecarboxylate (Pre084) Increases GDNF and BiP Expression and Promotes Neuroprotection after Root Avulsion Injury

(2011) Clara Penas et al.   JOURNAL OF NEUROTRAUMA

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

(2011) Wenjun Song et al.   NATURE MEDICINE

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

Porcine Circovirus Type 2 Morphogenesis in a Clone Derived from the L35 Lymphoblastoid Cell Line

(2010) C. Rodríguez-Cariño et al.   JOURNAL OF COMPARATIVE PATHOLOGY

Overexpressing GRP78 influences Ca2+ handling and function of mitochondria in astrocytes after ischemia-like stress

(2010) Yi-Bing Ouyang et al.   MITOCHONDRION

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Post-treatment of a BiP inducer prevents cell death after middle cerebral artery occlusion in mice

(2010) Yasuhisa Oida et al.   NEUROSCIENCE LETTERS

Cytoskeletal and Activity-Related Changes in Spinal Motoneurons after Root Avulsion

(2009) Clara Penas et al.   JOURNAL OF NEUROTRAUMA

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Selective sigma receptor agonist 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate (PRE084) promotes neuroprotection and neurite elongation through protein kinase C (PKC) signaling on motoneurons

(2009) M.-S. Guzmán-Lenis et al.   NEUROSCIENCE

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis

(2007) Chih-Wen Shu et al.   JOURNAL OF CELLULAR PHYSIOLOGY