Immunogenic-cell-killing and immunosuppression-inhibiting nanomedicine

Rapid Self-Assembly of Polymer Nanoparticles for Synergistic Codelivery of Paclitaxel and Lapatinib via Flash NanoPrecipitation

(2020) Shani L. Levit et al.   Nanomaterials

Shifting the absorption to the near-infrared region and inducing a strong photothermal effect by encapsulating zinc(II) phthalocyanine in poly(lactic-co-glycolic acid)-hyaluronic acid nanoparticles

(2020) Di Gao et al.   Acta Biomaterialia

A materials-science perspective on tackling COVID-19

(2020) Zhongmin Tang et al.   Nature Reviews Materials

Calcium-mineralized polypeptide nanoparticle for intracellular drug delivery in osteosarcoma chemotherapy

(2020) Ke Li et al.   Bioactive Materials

Insights from nanotechnology in COVID-19 treatment

(2020) Zhongmin Tang et al.   Nano Today

Nanoenabled Reversal of IDO1-Mediated Immunosuppression Synergizes with Immunogenic Chemotherapy for Improved Cancer Therapy

(2019) Hua Huang et al.   NANO LETTERS

Self‐Amplified Drug Delivery with Light‐Inducible Nanocargoes to Enhance Cancer Immunotherapy

(2019) Bing Feng et al.   ADVANCED MATERIALS

Engineered collagen-binding serum albumin as a drug conjugate carrier for cancer therapy

(2019) Koichi Sasaki et al.   Science Advances

Sequentially responsive biomimetic nanoparticles with optimal size in combination with checkpoint blockade for cascade synergetic treatment of breast cancer and lung metastasis

(2019) Wenqi Yu et al.   BIOMATERIALS

DNA-templated porous nanoplatform towards programmed “double-hit” cancer therapy via hyperthermia and immunogenicity activation

(2019) Jing Zhou et al.   BIOMATERIALS

Mild photothermal therapy potentiates anti-PD-L1 treatment for immunologically cold tumors via an all-in-one and all-in-control strategy

(2019) Liping Huang et al.   Nature Communications

Recent advances in nanosized drug delivery systems for overcoming the barriers to anti-PD immunotherapy of cancer

(2019) Xiaochen Liu et al.   Nano Today

Nanoplatform Assembled from a CD44-Targeted Prodrug and Smart Liposomes for Dual Targeting of Tumor Microenvironment and Cancer Cells

(2018) Yaqi Lv et al.   ACS Nano

Size/Charge Changeable Acidity-Responsive Micelleplex for Photodynamic-Improved PD-L1 Immunotherapy with Enhanced Tumor Penetration

(2018) Liangliang Dai et al.   ADVANCED FUNCTIONAL MATERIALS

Injectable Bioresponsive Gel Depot for Enhanced Immune Checkpoint Blockade

(2018) Shuangjiang Yu et al.   ADVANCED MATERIALS

Cargo-Free Nanomedicine with pH Sensitivity for Codelivery of DOX Conjugated Prodrug with SN38 To Synergistically Eradicate Breast Cancer Stem Cells

(2018) Na Sun et al.   MOLECULAR PHARMACEUTICS

Binary Cooperative Prodrug Nanoparticles Improve Immunotherapy by Synergistically Modulating Immune Tumor Microenvironment

(2018) Bing Feng et al.   ADVANCED MATERIALS

Inosine – a Multifunctional Treatment for Complications of Neurologic Injury

(2018) Claire Doyle et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Thermo- and pH-dual responsive polymeric micelles with upper critical solution temperature behavior for photoacoustic imaging-guided synergistic chemo-photothermal therapy against subcutaneous and metastatic breast tumors

(2018) Zhe Yang et al.   Theranostics

Breast Cancer Chemo-immunotherapy through Liposomal Delivery of an Immunogenic Cell Death Stimulus Plus Interference in the IDO-1 Pathway

(2018) Jianqin Lu et al.   ACS Nano

Reimagining IDO Pathway Inhibition in Cancer Immunotherapy via Downstream Focus on the Tryptophan–Kynurenine–Aryl Hydrocarbon Axis

(2018) Brian W. Labadie et al.   CLINICAL CANCER RESEARCH

pH-Sensitive Poly(β-amino ester)s Nanocarriers Facilitate the Inhibition of Drug Resistance in Breast Cancer Cells

(2018) Mengxue Zhou et al.   Nanomaterials

New Epigallocatechin Gallate (EGCG) Nanocomplexes Co-Assembled with 3-Mercapto-1-Hexanol and β-Lactoglobulin for Improvement of Antitumor Activity

(2017) Yuanyuan Yang et al.   Journal of Biomedical Nanotechnology

T-cell invigoration to tumour burden ratio associated with anti-PD-1 response

(2017) Alexander C. Huang et al.   NATURE

How to manipulate the upper critical solution temperature (UCST)?

(2017) Jukka Niskanen et al.   Polymer Chemistry

Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression

(2017) Jianqin Lu et al.   Nature Communications

Indoleamine-2,3-dioxygenase and Interleukin-6 associated with tumor response to neoadjuvant chemotherapy in breast cancer

(2017) Fangxuan Li et al.   Oncotarget

Hybrid nanoparticles coated with hyaluronic acid lipoid for targeted co-delivery of paclitaxel and curcumin to synergistically eliminate breast cancer stem cells

(2017) Zhe Yang et al.   Journal of Materials Chemistry B

Smart multifunctional polyurethane microcapsules for the quick release of anticancer drugs in BGC 823 and HeLa tumor cells

(2017) Yuqing Niu et al.   Journal of Materials Chemistry B

Synergistic Transcutaneous Immunotherapy Enhances Antitumor Immune Responses through Delivery of Checkpoint Inhibitors

(2016) Yanqi Ye et al.   ACS Nano

Dual-targeting hybrid nanoparticles for the delivery of SN38 to Her2 and CD44 overexpressed human gastric cancer

(2016) Zhe Yang et al.   Nanoscale

Redox-controlled upper critical solution temperature behaviour of a nitroxide containing polymer in alcohol–water mixtures

(2016) Olivier Bertrand et al.   Polymer Chemistry

An immunostimulatory dual-functional nanocarrier that improves cancer immunochemotherapy

(2016) Yichao Chen et al.   Nature Communications

Tumor-Penetrating Nanotherapeutics Loading a Near-Infrared Probe Inhibit Growth and Metastasis of Breast Cancer

(2015) Xinyu He et al.   ADVANCED FUNCTIONAL MATERIALS

Hyaluronic acid-decorated dual responsive nanoparticles of Pluronic F127, PLGA, and chitosan for targeted co-delivery of doxorubicin and irinotecan to eliminate cancer stem-like cells

(2015) Hai Wang et al.   BIOMATERIALS

Tumor indoleamine 2,3-dioxygenase (IDO) inhibits CD19-CAR T cells and is downregulated by lymphodepleting drugs

(2015) Soranobu Ninomiya et al.   BLOOD

Self-assembled UCST-Type Micelles as Potential Drug Carriers for Cancer Therapeutics

(2015) Gang Huang et al.   MACROMOLECULAR CHEMISTRY AND PHYSICS

Synergistically Enhanced Therapeutic Effect of a Carrier-Free HCPT/DOX Nanodrug on Breast Cancer Cells through Improved Cellular Drug Accumulation

(2015) Fei Chen et al.   MOLECULAR PHARMACEUTICS

Tumor-Expressed IDO Recruits and Activates MDSCs in a Treg-Dependent Manner

(2015) Rikke B. Holmgaard et al.   Cell Reports

Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR

(2015) Ulrike M. Litzenburger et al.   Oncotarget

A first in man phase I trial of the oral immunomodulator, indoximod, combined with docetaxel in patients with metastatic solid tumors

(2015) Hatem H. Soliman et al.   Oncotarget

Analysis of metabolites in plasma reveals distinct metabolic features between Dahl salt-sensitive rats and consomic SS.13BN rats

(2014) Le Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Curcumin nanoformulations: A review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment

(2014) Ornchuma Naksuriya et al.   BIOMATERIALS

Influence of Hydrophobic Anion on Solution Properties of PDMAEMA

(2014) Erno Karjalainen et al.   MACROMOLECULES

CGKRK-modified nanoparticles for dual-targeting drug delivery to tumor cells and angiogenic blood vessels

(2013) Quanyin Hu et al.   BIOMATERIALS

Molecular mechanisms of ATP secretion during immunogenic cell death

(2013) I Martins et al.   CELL DEATH AND DIFFERENTIATION

Thermoresponsiveness of PDMAEMA. Electrostatic and Stereochemical Effects

(2013) Jukka Niskanen et al.   MACROMOLECULES

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

First Example of a Universal and Cost-Effective Approach: Polymers with Tunable Upper Critical Solution Temperature in Water and Electrolyte Solution

(2012) Jan Seuring et al.   MACROMOLECULES

IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan

(2012) Richard Metz et al.   OncoImmunology

Drug-loaded polyelectrolyte microcapsules for sustained targeting of cancer cells

(2011) Viviana Vergaro et al.   ADVANCED DRUG DELIVERY REVIEWS

Lapatinib/Paclitaxel polyelectrolyte nanocapsules for overcoming multidrug resistance in ovarian cancer

(2011) Daniele Vergara et al.   Nanomedicine-Nanotechnology Biology and Medicine

Top-down and bottom-up approaches in production of aqueous nanocolloids of low solubility drug paclitaxel

(2011) P. Pattekari et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity

(2010) X. Liu et al.   BLOOD

Immunogenic Tumor Cell Death for Optimal Anticancer Therapy: The Calreticulin Exposure Pathway

(2010) L. Zitvogel et al.   CLINICAL CANCER RESEARCH

COX-2 and PGE2 signaling is essential for the regulation of IDO expression by curcumin in murine bone marrow-derived dendritic cells

(2010) In Duk Jung et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Hydroxyamidine Inhibitors of Indoleamine-2,3-dioxygenase Potently Suppress Systemic Tryptophan Catabolism and the Growth of IDO-Expressing Tumors

(2010) H. K. Koblish et al.   MOLECULAR CANCER THERAPEUTICS

Curcumin Suppresses the Induction of Indoleamine 2,3-Dioxygenase by Blocking the Janus-activated Kinase-Protein Kinase Cδ-STAT1 Signaling Pathway in Interferon-γ-stimulated Murine Dendritic Cells

(2008) Young-Il Jeong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY