Soft overcomes the hard: Flexible materials adapt to cell adhesion to promote cell mechanotransduction

Dynamically re‐organized collagen fiber bundles transmit mechanical signals and induce strongly correlated cell migration and self‐organization

(2021) Qihui Fan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Articular cartilage and osteochondral tissue engineering techniques: Recent advances and challenges

(2021) Wenying Wei et al.   Bioactive Materials

Surface Roughness Gradients Reveal Topography‐Specific Mechanosensitive Responses in Human Mesenchymal Stem Cells

(2020) Yong Hou et al.   Small

Nanoscale integrin cluster dynamics controls cellular mechanosensing via FAKY397 phosphorylation

(2020) Bo Cheng et al.   Science Advances

Ligand Diffusion Enables Force‐Independent Cell Adhesion via Activating α5β1 Integrin and Initiating Rac and RhoA Signaling

(2020) Leixiao Yu et al.   ADVANCED MATERIALS

Soft Hydrogels for Balancing Cell Proliferation and Differentiation

(2020) Qiang Wei et al.   ACS Biomaterials-Science & Engineering

Effects of extracellular matrix viscoelasticity on cellular behaviour

(2020) Ovijit Chaudhuri et al.   NATURE

Self‐Strengthening Adhesive Force Promotes Cell Mechanotransduction

(2020) Leixiao Yu et al.   ADVANCED MATERIALS

Cell migration regulated by RGD nanospacing and enhanced under moderate cell adhesion on biomaterials

(2020) Qiong Liu et al.   BIOMATERIALS

Controllable ligand spacing stimulates cellular mechanotransduction and promotes stem cell osteogenic differentiation on soft hydrogels

(2020) Man Zhang et al.   BIOMATERIALS

Cell force-mediated matrix reorganization underlies multicellular network assembly

(2019) Christopher D. Davidson et al.   Scientific Reports

Cell cycle progression in confining microenvironments is regulated by a growth-responsive TRPV4-PI3K/Akt-p27Kip1 signaling axis

(2019) Sungmin Nam et al.   Science Advances

Surface Roughness and Substrate Stiffness Synergize To Drive Cellular Mechanoresponse

(2019) Yong Hou et al.   NANO LETTERS

Stress relaxing hyaluronic acid-collagen hydrogels promote cell spreading, fiber remodeling, and focal adhesion formation in 3D cell culture

(2018) Junzhe Lou et al.   BIOMATERIALS

Degradation rate affords a dynamic cue to regulate stem cells beyond varied matrix stiffness

(2018) Yuanmeng Peng et al.   BIOMATERIALS

Protein Nanosheet Mechanics Controls Cell Adhesion and Expansion on Low-Viscosity Liquids

(2018) Dexu Kong et al.   NANO LETTERS

Mitotic cells generate protrusive extracellular forces to divide in three-dimensional microenvironments

(2018) Sungmin Nam et al.   Nature Physics

Matching material and cellular timescales maximizes cell spreading on viscoelastic substrates

(2018) Ze Gong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular clutch drives cell response to surface viscosity

(2018) Mark Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of Mechanotransduction by Molecular Clutch Dynamics

(2018) Alberto Elosegui-Artola et al.   TRENDS IN CELL BIOLOGY

Recent Advances in Engineering the Stem Cell Microniche in 3D

(2018) Min Bao et al.   Advanced Science

Adaptable Fast Relaxing Boronate-Based Hydrogels for Probing Cell-Matrix Interactions

(2018) Shengchang Tang et al.   Advanced Science

Hydrazone covalent adaptable networks modulate extracellular matrix deposition for cartilage tissue engineering

(2018) Benjamin M. Richardson et al.   Acta Biomaterialia

Steps in Mechanotransduction Pathways that Control Cell Morphology

(2018) Haguy Wolfenson et al.   Annual Review of Physiology

Force loading explains spatial sensing of ligands by cells

(2017) Roger Oria et al.   NATURE

Mechanical confinement regulates cartilage matrix formation by chondrocytes

(2017) Hong-pyo Lee et al.   NATURE MATERIALS

Viscoelastic hydrogels for 3D cell culture

(2017) Ovijit Chaudhuri   Biomaterials Science

In vitro fibrillogenesis of tropocollagen type III in collagen type I affects its relative fibrillar topology and mechanics

(2017) Meisam Asgari et al.   Scientific Reports

The molecular clutch model for mechanotransduction evolves

(2016) Vinay Swaminathan et al.   NATURE CELL BIOLOGY

Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity

(2016) Alberto Elosegui-Artola et al.   NATURE CELL BIOLOGY

Fibrous nonlinear elasticity enables positive mechanical feedback between cells and ECMs

(2016) Matthew S. Hall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanotransduction: use the force(s)

(2015) Ewa K. Paluch et al.   BMC BIOLOGY

Integrins Direct Cell Adhesion in a Substrate-Dependent Manner

(2015) Andreas P. Kourouklis et al.   Cellular and Molecular Bioengineering

Effects of Nanoscale Spatial Arrangement of Arginine–Glycine–Aspartate Peptides on Dedifferentiation of Chondrocytes

(2015) Shiyu Li et al.   NANO LETTERS

Fabrication of RGD Micro/Nanopattern and Corresponding Study of Stem Cell Differentiation

(2015) Xuan Wang et al.   NANO LETTERS

Matrix Stiffness and Nanoscale Spatial Organization of Cell-Adhesive Ligands Direct Stem Cell Fate

(2015) Kai Ye et al.   NANO LETTERS

Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments

(2015) Brendon M. Baker et al.   NATURE MATERIALS

Stress-stiffening-mediated stem-cell commitment switch in soft responsive hydrogels

(2015) Rajat K. Das et al.   NATURE MATERIALS

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

(2015) Ovijit Chaudhuri et al.   NATURE MATERIALS

Substrate stress relaxation regulates cell spreading

(2015) Ovijit Chaudhuri et al.   Nature Communications

Surface topography and chemistry shape cellular behavior on wide band-gap semiconductors

(2014) Lauren E. Bain et al.   Acta Biomaterialia

Mussel-Inspired Dendritic Polymers as Universal Multifunctional Coatings

(2014) Qiang Wei et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cell adhesion mechanisms on laterally mobile polymer films

(2014) Andreas P. Kourouklis et al.   BIOMATERIALS

Rigidity sensing and adaptation through regulation of integrin types

(2014) Alberto Elosegui-Artola et al.   NATURE MATERIALS

Interplay of matrix stiffness and protein tethering in stem cell differentiation

(2014) Jessica H. Wen et al.   NATURE MATERIALS

Harnessing nanotopography and integrin–matrix interactions to influence stem cell fate

(2014) Matthew J. Dalby et al.   NATURE MATERIALS

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell-Material Interactions Revealed Via Material Techniques of Surface Patterning

(2013) Xiang Yao et al.   ADVANCED MATERIALS

Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels

(2013) Sudhir Khetan et al.   NATURE MATERIALS

Mechanical assessment of elastin integrity in fibrillin-1-deficient carotid arteries: implications for Marfan syndrome

(2011) Jacopo Ferruzzi et al.   CARDIOVASCULAR RESEARCH

Impact of Order and Disorder in RGD Nanopatterns on Cell Adhesion

(2009) Jinghuan Huang et al.   NANO LETTERS

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

The role of matrix stiffness in regulating cell behavior

(2008) Rebecca G. Wells   HEPATOLOGY