Review
Nutrition & Dietetics
Amelia K. Fotheringham, Linda A. Gallo, Danielle J. Borg, Josephine M. Forbes
Summary: Since the 1980s, the incidence of chronic kidney disease (CKD) has increased by almost 25%. This is partly due to changes in lifestyle and the global consumption of a western diet, which is high in energy, low in fruits and vegetables, and rich in animal protein and processed foods. These dietary trends have led to an increase in the consumption of advanced glycation end products (AGEs) and metabolic disorders, obesity, and diabetes, which contribute to the production of endogenous AGEs in the body. Excessive accumulation of AGEs can be pathologic through receptor-mediated and non-receptor-mediated pathways. AGEs are cleared by the kidneys, making them particularly susceptible to AGE-mediated damage, and high levels of circulating AGEs are associated with an increased risk of CKD and all-cause mortality. Individuals with significant loss of renal function have increased AGE burden, particularly in those with uremia, and there is evidence that lowering AGEs through diet or pharmacological inhibition may be beneficial for CKD. This review explores the pathways of AGE formation and regulation in the body, the impact of diet on endogenous AGE production and dietary AGE consumption, the contribution of AGEs to kidney disease, and the potential of AGE-targeted therapies for kidney disease.
Review
Biochemistry & Molecular Biology
Elena Dozio, Simone Vettoretti, Giuseppe Lungarella, Piergiorgio Messa, Massimiliano M. Corsi Romanelli
Summary: Sarcopenia in chronic kidney disease is independently associated with morbidity and mortality, with advanced glycation end products (AGE) playing a key role in its pathogenesis. The imbalance of oxidant/antioxidant capacities in CKD patients leads to AGE accumulation, which can promote CKD progression and related complications by inducing inflammation and fibrosis. Understanding the link between AGE and oxidative stress in the onset of sarcopenia may help identify new markers for disease progression and therapeutic targets.
Review
Biochemistry & Molecular Biology
Elena Dozio, Lara Caldiroli, Paolo Molinari, Giuseppe Castellano, Nicholas Walter Delfrate, Massimiliano Marco Corsi Romanelli, Simone Vettoretti
Summary: Advanced glycation end products (AGEs) are aging products that accumulate in chronic kidney disease (CKD) due to increased production, reduced excretion, and imbalance between oxidant/antioxidant capacities. This review aims to summarize the knowledge of AGEs in CKD onset and progression, focusing on related disorders and mortality. The role of AGEs as etiopathogenetic molecules and potential markers or therapeutic targets will be discussed.
Article
Biochemistry & Molecular Biology
Paolo Molinari, Lara Caldiroli, Elena Dozio, Roberta Rigolini, Paola Giubbilini, Massimiliano M. Corsi Romanelli, Giuseppe Castellano, Simone Vettoretti
Summary: This study found that advanced glycation end-products (AGEs) are associated with the presence of sarcopenia in patients with chronic kidney disease (CKD), while soluble receptor for AGE (sRAGE) is not. AGEs may contribute to the complex pathophysiology leading to the development of sarcopenia in CKD patients.
Review
Biochemistry & Molecular Biology
Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Melaku Mekonnen Agidew, Muluken Teshome Azezew, Edgeit Abebe Zewde, Assefa Agegnehu Teshome
Summary: Hyperglycemia leads to protein glycation and accumulation of advanced glycation end products, which play a significant role in the development of diabetes complications. Their contribution occurs through receptor-mediated signaling cascade or direct extracellular matrix destruction.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Mieke Steenbeke, Reinhart Speeckaert, Stephanie Desmedt, Griet Glorieux, Joris R. Delanghe, Marijn M. Speeckaert
Summary: Patients with chronic kidney disease (CKD) are more prone to oxidative stress and chronic inflammation, resulting in increased production and decreased clearance of advanced glycation end products (AGEs). AGEs may contribute to decreased kidney function and increased all-cause mortality in CKD patients. Interaction between AGEs and their cell-bound receptor RAGE activates nuclear factor kappa-B (NF-kappa B), leading to cell dysfunction and increased production of inflammatory cytokines. Alterations in the AGE-RAGE system are associated with the development of various chronic kidney diseases. Soluble RAGE (sRAGE) acts as a decoy receptor to inhibit membrane-bound RAGE activation and AGE-RAGE-related toxicity. The ratio of AGEs to sRAGE may be a useful tool for predicting the prognosis of kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lara Caldiroli, Paolo Molinari, Elena Dozio, Roberta Rigolini, Paola Giubbilini, Massimiliano M. Corsi Romanelli, Giuseppe Castellano, Simone Vettoretti
Summary: This study investigated the relationship between inflammation, advanced glycation end-products (AGEs), and their receptors (RAGEs) with malnutrition in patients with chronic kidney disease (CKD). The results showed that RAGEs isoforms, but not AGEs, were associated with malnutrition in CKD patients.
Review
Immunology
Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
Summary: Advanced glycation end products (AGEs) are biologically active compounds that react with proteins to generate reactive aldehydes. They accumulate in tissues during ageing and in various metabolic and inflammatory disorders such as type 2 diabetes, obesity, cardiovascular diseases, chronic renal insufficiency, and psoriasis. The interaction of AGEs with their receptors (RAGEs) leads to cellular signaling, oxidative stress, and activation of inflammatory mediators. AGEs may play a pathogenic role in the intersection of inflammatory and metabolic diseases and could be a potential target for therapeutic strategies.
Article
Biochemistry & Molecular Biology
Abbas Mohtashamian, Alireza Soleimani, Hamid Reza Gilasi, Nejat Kheiripour, Seyed Masoud Moeini Taba, Nasrin Sharifi
Summary: This study investigated the correlation of serum zinc with MMP-2, MMP-9, AGEs, and blood pressure in CKD patients. The results showed that serum zinc was negatively correlated with MMP-9 and creatinine, and positively correlated with dietary zinc intake and eGFR.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Camille Majchrzak, Audrey Cougnard-Gregoire, Melanie Le-Goff, Catherine Feart, Cecile Delcourt, Mathilde Reydit, Catherine Helmer, Vincent Rigalleau
Summary: Skin autofluorescence is associated with increased all-cause mortality in older adults already suffering from chronic kidney disease (CKD).
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Raphael S. Pinto, Carlos A. Minanni, Aecio Lopes de Araujo Lira, Marisa Passarelli
Summary: This review focuses on the role of advanced glycation end products (AGEs) in cardiovascular disease (CVD). Clinical trials and experimental evidence are used to revisit the mechanisms by which AGEs contribute to CVD, including enhanced oxidative stress, inflammation, endoplasmic reticulum stress, and impairment in reverse cholesterol transport (RCT). AGEs promote cholesterol accumulation in the arterial wall through these pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Bowen Wang, Deepak Vashishth
Summary: Hyperglycemia and oxidative stress in diabetes and aging lead to excessive accumulation of advanced glycation and glycoxidation end products (AGEs/AGOEs) in bone. AGEs/AGOEs disrupt bone turnover and deteriorate bone quality through alterations of organic matrix, mineral, and water content. This review explains the accumulation and impact of AGEs/AGOEs in bone, as well as their targeting in preclinical and clinical investigations for the management of diabetic, osteoporotic, and insufficiency fractures.
Review
Urology & Nephrology
John G. Damrath, Amy Creecy, Joseph M. Wallace, Sharon M. Moe
Summary: This review highlights the detrimental effects of advanced glycation end products (AGEs) on bone structure and mechanical properties, emphasizing the importance of considering bone quality in assessing fracture risk in CKD patients.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2021)
Article
Agriculture, Multidisciplinary
Hong Sun, Juan Chen, Lili Sun, Bimin Shi, Jianzhong Li
Summary: Research found that silencing TXNIP can reduce renal lipid deposition, inhibit cholesterol uptake and synthesis through regulating SCAP, and may be a potential therapeutic target for treating a diabetic fatty kidney.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Kamil Litwinowicz, Ewa Waszczuk, Aleksandra Kuzan, Agnieszka Bronowicka-Szydelko, Kinga Gostomska-Pampuch, Piotr Naporowski, Andrzej Gamian
Summary: The biochemical mechanisms associated with the progression of alcoholic liver disease (ALD) to alcoholic hepatitis (AH) remain a challenge. The study found that the novel advanced glycation end-product AGE10 is significantly associated with AH, and showed acceptable diagnostic performance.
Article
Nutrition & Dietetics
Roni Lotan, Ithamar Ganmore, Abigail Livny, Shahar Shelly, Moran Zacharia, Jaime Uribarri, Paul Beisswenger, Weijing Cai, Michal Schnaider Beeri, Aron M. Troen
Summary: In this pilot trial, researchers found that reducing dietary intake of AGEs in elderly individuals with diabetes can lower the level of AGEs in the serum and potentially have a beneficial effect on metabolic biomarkers. This suggests that feasible lifestyle modifications targeting AGEs may help prevent cognitive decline in high-risk populations.
FRONTIERS IN NUTRITION
(2021)
Article
Urology & Nephrology
Kinsuk Chauhan, Pattharawin Pattharanitima, Federica Piani, Richard J. Johnson, Jaime Uribarri, Lili Chan, Steven G. Coca
Summary: This study found that higher serum UA levels were independently associated with AKI, MAKE, and in-hospital mortality in a dose-dependent manner in patients admitted to the hospital for COVID-19. Hyperuricemia was also associated with higher procalcitonin and troponin I levels.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
Review
Urology & Nephrology
Katherine R. Tuttle, Rajiv Agarwal, Charles E. Alpers, George L. Bakris, Frank C. Brosius, Peter Kolkhof, Jaime Uribarri
Summary: Diabetic kidney disease is a global burden that increases the risk of kidney failure and cardiovascular events. There is a need to understand the molecular mechanisms of the disease and find new therapies. Inflammatory and fibrotic mediators play important roles in the pathophysiology of the disease. Recent clinical trials have shown promising drug therapies and dietary strategies for treating diabetic kidney disease.
KIDNEY INTERNATIONAL
(2022)
Article
Nutrition & Dietetics
Michal Schnaider Beeri, Roni Lotan, Jaime Uribarri, Sue Leurgans, David A. Bennett, Aron S. Buchman
Summary: This study investigated the associations between dietary-derived advanced glycation end products (AGEs) and cognitive decline in older adults. The results showed that higher levels of dietary AGEs were associated with a faster rate of cognitive decline, particularly in episodic memory and perceptual speed. These findings highlight the importance of diet in preventing late-life cognitive impairment.
Article
Urology & Nephrology
Jaime Uribarri, David S. Goldfarb, Kalani L. Raphael, Joshua L. Rein, John R. Asplin
Summary: Ammonium is an important parameter in urine that can provide important clues about the causes of metabolic acidosis. The urinary anion gap (UAG) is not a good predictor of UNH4, and measuring UNH4 is important in clinical nephrology.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Urology & Nephrology
Marzuq Billah, Jaime Uribarri, Elliot Charen, Shuchita Sharma
Summary: This study presents a series of peritonitis cases with unusual organisms in a single home dialysis center in New York City. These uncommon cases highlight the importance of various elements that can lead to peritonitis.
SEMINARS IN DIALYSIS
(2023)
Article
Urology & Nephrology
Osama El Shamy, Sara Atallah, Shuchita Sharma, Jaime Uribarri
Summary: This study compared the effects of different PD cyclers (AMIA and HomeChoice Pro) on patient treatments and support needs. The results showed that regardless of the cycler used, patient overall satisfaction rates were high.
Article
Urology & Nephrology
Maryanne Y. Sourial, Anirudh Gone, Jaime Uribarri, Vesh Srivatana, Shuchita Sharma, Daniil Shimonov, Michael Chang, Wenzhu Mowrey, Rochelle Dalsan, Kaltrina Sedaliu, Swati Jain, Michael J. Ross, Nina Caplin, Wei Chen
Summary: During the peak of the COVID-19 pandemic, the use of peritoneal dialysis (PD) for the treatment of acute kidney injury (AKI) was not associated with worse clinical outcomes compared to extracorporeal dialysis.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Hana Kahleova, Tatiana Znayenko-Miller, Jaime Uribarri, Richard Holubkov, Neal D. Barnard
Summary: This study aimed to assess the effects of a low-fat plant-based diet on dietary AGEs and their association with body weight, body composition, and insulin sensitivity. The results showed that a low-fat plant-based diet decreased dietary AGEs and this decrease was associated with changes in body weight, body composition, and insulin sensitivity, independent of energy intake.
OBESITY SCIENCE & PRACTICE
(2023)
Editorial Material
Nutrition & Dietetics
Mona S. Calvo, Jaime Uribarri
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
(2023)
Letter
Medicine, General & Internal
Jaime Uribarri, Lorena Drago, Arnold R. R. Eiser
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Hana Kahleova, Tatiana Znayenko-Miller, Jaime Uribarri, Natalie Schmidt, Sinjana Kolipaka, Ellen Hata, Danielle N. Holtz, Macy Sutton, Richard Holubkov, Neal D. Barnard
Summary: This study investigated the potential association between modifications to the intake of dietary advanced glycation end-products (AGEs) and the frequency and severity of postmenopausal hot flashes. The study found that adhering to a low-fat vegan diet was significantly associated with a reduction in the frequency and severity of hot flashes in postmenopausal women, independent of changes in energy intake and weight loss.
Review
Cell Biology
Manuel Portero-Otin, M. Pia de la Maza, Jaime Uribarri
Summary: Insulin resistance is commonly observed during aging and is a major factor in chronic nontransmissible diseases. Diet, particularly the intake of advanced glycation end products (AGEs), plays a significant role in causing insulin resistance. Clinical trials and animal studies suggest that reducing dietary AGE intake can improve insulin resistance.
Review
Nutrition & Dietetics
Mona S. Calvo, Elizabeth K. Dunford, Jaime Uribarri
Summary: The consumption of ultra-processed food (UPF) is increasing, and numerous epidemiological studies have found a link between high UPF consumption and serious health issues like cardiovascular disease. This review focuses on the potential role of inorganic phosphate additives, commonly found in UPF, in contributing to negative cardiorenal effects. Inorganic phosphates are rapidly absorbed and can lead to negative effects on the heart and kidneys through calcification and the release of mineral-regulating hormones. The precise extent of the association between inorganic phosphate additives and health outcomes needs further investigation.
Letter
Urology & Nephrology
Osama El Shamy, Aditya Jain, Marzuq Billah, Shuchita Sharma, Jaime Uribarri