The Impact of Angiotensin-Converting Enzyme 2 (ACE2) Expression Levels in Patients with Comorbidities on COVID-19 Severity: A Comprehensive Review

The association between clinical laboratory data and chest CT findings explains disease severity in a large Italian cohort of COVID-19 patients

(2021) Simone Canovi et al.   BMC INFECTIOUS DISEASES

Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies

(2021) Allison J. Greaney et al.   Cell Host & Microbe

Emergence of a SARS-CoV-2 variant of concern with mutations in spike glycoprotein

(2021) Houriiyah Tegally et al.   NATURE

Nasal expression of SARS-CoV-2 entry receptors in newborns

(2021) Santtu Heinonen et al.   Archives of Disease in Childhood-Fetal and Neonatal Edition

Insilico study on the effect of SARS-CoV-2 RBD hotspot mutants’ interaction with ACE2 to understand the binding affinity and stability

(2021) Jyoti Verma et al.   VIROLOGY

Risk of hospital admission for patients with SARS-CoV-2 variant B.1.1.7: cohort analysis

(2021) Tommy Nyberg et al.   BMJ-British Medical Journal

Susceptibility to SARS-CoV-2 infection in patients undergoing chemotherapy and radiation therapy

(2021) Claudia Rita Corso et al.   Journal of Infection and Public Health

Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China

(2020) Zunyou Wu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

(2020) Jasper Fuk-Woo Chan et al.   LANCET

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Importation and Human-to-Human Transmission of a Novel Coronavirus in Vietnam

(2020) Lan T. Phan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

(2020) Yingxia Liu et al.   Science China-Life Sciences

High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa

(2020) Hao Xu et al.   International Journal of Oral Science

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

(2020) Xiaobo Yang et al.   Lancet Respiratory Medicine

Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses

(2020) Furong Qi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2

(2020) Liang Chen et al.   CARDIOVASCULAR RESEARCH

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Association of Inpatient Use of Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers with Mortality Among Patients With Hypertension Hospitalized With COVID-19

(2020) Peng Zhang et al.   CIRCULATION RESEARCH

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System

(2020) Mahmoud Gheblawi et al.   CIRCULATION RESEARCH

What we know so far: COVID-19 current clinical knowledge and research

(2020) Mary A Lake   CLINICAL MEDICINE

Active smoking is not associated with severity of coronavirus disease 2019 (COVID-19)

(2020) Giuseppe Lippi et al.   European Journal of Internal Medicine

ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19

(2020) Janice M. Leung et al.   EUROPEAN RESPIRATORY JOURNAL

Interactions of coronaviruses with ACE2, angiotensin II, and RAS inhibitors—lessons from available evidence and insights into COVID-19

(2020) Hisashi Kai et al.   HYPERTENSION RESEARCH

Do checkpoint inhibitors compromise the cancer patients’ immunity and increase the vulnerability to COVID-19 infection?

(2020) Joseph Kattan et al.   Immunotherapy

Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults

(2020) Supinda Bunyavanich et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Type 2 Inflammation Modulates ACE2 and TMPRSS2 in Airway Epithelial Cells

(2020) Hiroki Kimura et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

COVID-19 and diabetes: The why, the what and the how

(2020) Sarah Cuschieri et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

COVID‐19 and Renin‐Angiotensin system inhibition – role of angiotensin converting enzyme 2 (ACE2) ‐ Is there any scientific evidence for controversy?

(2020) Aneta Aleksova et al.   JOURNAL OF INTERNAL MEDICINE

ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome

(2020) Christian A. Devaux et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Angiotensin‐converting enzyme‐2 ( ACE2 ), SARS‐CoV ‐2 and pathophysiology of coronavirus disease 2019 ( COVID ‐19)

(2020) Arno R. Bourgonje et al.   JOURNAL OF PATHOLOGY

COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study

(2020) Lennard Y W Lee et al.   LANCET

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

SARS-CoV-2: virus dynamics and host response

(2020) Yu Chen et al.   LANCET INFECTIOUS DISEASES

Droplets and Aerosols in the Transmission of SARS-CoV-2

(2020) Matthew Meselson   NEW ENGLAND JOURNAL OF MEDICINE

Renin–Angiotensin–Aldosterone System Inhibitors and Risk of Covid-19

(2020) Harmony R. Reynolds et al.   NEW ENGLAND JOURNAL OF MEDICINE

Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1

(2020) Neeltje van Doremalen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increased ACE2 Expression in the Bronchial Epithelium of COPD Patients who are Overweight

(2020) Andrew Higham et al.   Obesity

High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation

(2020) Arthur Simonnet et al.   Obesity

Racial Variations in COVID‐19 Deaths May Be Due to Androgen Receptor Genetic Variants Associated with Prostate Cancer and Androgenetic Alopecia. Are Anti‐Androgens a Potential Treatment for COVID‐19?

(2020) John McCoy et al.   Journal of Cosmetic Dermatology

Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study

(2020) Shufa Zheng et al.   BMJ-British Medical Journal

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children and Adolescents

(2020) Riccardo Castagnoli et al.   JAMA Pediatrics

Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations

(2020) Jason Phua et al.   Lancet Respiratory Medicine

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

(2020) Xin Zou et al.   Frontiers of Medicine

Smoking Upregulates Angiotensin-Converting Enzyme-2 Receptor: A Potential Adhesion Site for Novel Coronavirus SARS-CoV-2 (Covid-19)

(2020) Samuel James Brake et al.   Journal of Clinical Medicine

A profiling analysis on the receptor ACE2 expression reveals the potential risk of different type of cancers vulnerable to SARS-CoV-2 infection

(2020) Yu-Jun Dai et al.   Annals of Translational Medicine

Understanding the age divide in COVID-19: why are children overwhelmingly spared?

(2020) K. Lingappan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Overcoming Barriers

(2020) Dakota Gustafson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Renin-angiotensin system at the heart of COVID-19 pandemic

(2020) Marco Alifano et al.   BIOCHIMIE

Single-cell analysis of SARS-CoV-2 receptor ACE2 and spike protein priming expression of proteases in the human heart

(2020) Hanning Liu et al.   CARDIOVASCULAR RESEARCH

SARS-CoV-2 and the Nervous System: From Clinical Features to Molecular Mechanisms

(2020) Manuela Pennisi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Expression of SARS-CoV-2 receptor ACE2 and coincident host response signature varies by asthma inflammatory phenotype

(2020) Matthew Camiolo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

ACE2 Expression Is Increased in the Lungs of Patients With Comorbidities Associated With Severe COVID-19

(2020) Bruna G G Pinto et al.   JOURNAL OF INFECTIOUS DISEASES

COVID-19: the role of excessive cytokine release and potential ACE2 down-regulation in promoting hypercoagulable state associated with severe illness

(2020) Fenghe Du et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Viral dynamics in mild and severe cases of COVID-19

(2020) Yang Liu et al.   LANCET INFECTIOUS DISEASES

Angiotensin-Converting Enzyme 2 and Antihypertensives (Angiotensin Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors) in Coronavirus Disease 2019

(2020) Fabian Sanchis-Gomar et al.   MAYO CLINIC PROCEEDINGS

ACEI/ARB use and risk of infection or severity or mortality of COVID-19: A systematic review and meta-analysis

(2020) Xue Zhang et al.   PHARMACOLOGICAL RESEARCH

COVID-19 and comorbidities: Deleterious impact on infected patients

(2020) Hasan Ejaz et al.   Journal of Infection and Public Health

Evaluation of COVID-19 based on ACE2 expression in normal and cancer patients

(2020) Peng Ren et al.   Open Medicine

ACE2 and TMPRSS2 expression by clinical, HLA, immune, and microbial correlates across 34 human cancers and matched normal tissues: implications for SARS-CoV-2 COVID-19

(2020) Riyue Bao et al.   Journal for ImmunoTherapy of Cancer

Cancer Management during COVID-19 Pandemic: Is Immune Checkpoint Inhibitors-Based Immunotherapy Harmful or Beneficial?

(2020) Silvia Vivarelli et al.   Cancers

Expression Profile of SARS-CoV-2 Host Receptors in Human Pancreatic Islets Revealed Upregulation of ACE2 in Diabetic Donors

(2020) Jalal Taneera et al.   Biology-Basel

Sex steroids skew ACE2 expression in human airway: A contributing factor to sex differences in COVID-19?

(2020) Rama Satyanarayana Raju Kalidhindi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Expression of ACE2, the SARS-CoV-2 Receptor, in Lung Tissue of Patients With Type 2 Diabetes

(2020) Sara RA Wijnant et al.   DIABETES

ACE2 expression in allergic airway disease may decrease the risk and severity of COVID-19

(2020) Sunita Chhapola Shukla   EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

Association Between Renin-Angiotensin-Aldosterone System Inhibitors and COVID-19 Infection in South Korea

(2020) Minkook Son et al.   HYPERTENSION

Dysregulation of ACE2 Expression and Function in Co-morbid Disease Conditions Possibly Contributes to COVID-19 Complication Severity

(2020) Safaa Hammoud et al.   MOLECULAR PHARMACOLOGY

Gender susceptibility to COVID-19: a review of the putative role of sex hormones and X chromosome

(2020) C. Foresta et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

The Two Faces of ACE2: The Role of ACE2 Receptor and Its Polymorphisms in Hypertension and COVID-19

(2020) Mira Bosso et al.   Molecular Therapy-Methods & Clinical Development

Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men

(2020) Ryan M. Samuel et al.   Cell Stem Cell

Angiotensin-converting enzymes (ACE, ACE2) gene variants and COVID-19 outcome

(2020) Juan Gómez et al.   GENE

ACE2 exhibits protective effects against LPS-induced acute lung injury in mice by inhibiting the LPS-TLR4 pathway

(2019) Rensong Ye et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Nicotine and the Renin-Angiotensin System

(2018) Joshua M. Oakes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Role of the ACE2/Angiotensin 1–7 Axis of the Renin–Angiotensin System in Heart Failure

(2016) Vaibhav B. Patel et al.   CIRCULATION RESEARCH

Alternative Roles of STAT3 and MAPK Signaling Pathways in the MMPs Activation and Progression of Lung Injury Induced by Cigarette Smoke Exposure in ACE2 Knockout Mice

(2016) Yi-Han Hung et al.   International Journal of Biological Sciences

Angiotensin-converting enzyme 2 prevents lipopolysaccharide-induced rat acute lung injury via suppressing the ERK1/2 and NF-κB signaling pathways

(2016) Yingchuan Li et al.   Scientific Reports

Role of angiotensin-converting enzyme (ACE) and ACE2 in a rat model of smoke inhalation induced acute respiratory distress syndrome

(2015) Zhao Yilin et al.   BURNS

ACE2 deficiency worsens epicardial adipose tissue inflammation and cardiac dysfunction in response to diet-induced obesity

(2015) Vaibhav B. Patel et al.   DIABETES

ACE2 and Microbiota

(2015) Colleen T. Cole-Jeffrey et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

IFN  induces monopoiesis and inhibits neutrophil development during inflammation

(2011) A. M. de Bruin et al.   BLOOD

A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry

(2010) A. Shulla et al.   JOURNAL OF VIROLOGY

SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway

(2008) Hongliang Wang et al.   CELL RESEARCH