Withaferin a Triggers Apoptosis and DNA Damage in Bladder Cancer J82 Cells through Oxidative Stress

Molecular dynamics simulations and experimental studies reveal differential permeability of withaferin-A and withanone across the model cell membrane

(2021) Renu Wadhwa et al.   Scientific Reports

Manoalide Shows Mutual Interaction between Cellular and Mitochondrial Reactive Species with Apoptosis in Oral Cancer Cells

(2021) Hui-Ru Wang et al.   Oxidative Medicine and Cellular Longevity

Physalis peruviana-Derived Physapruin A (PHA) Inhibits Breast Cancer Cell Proliferation and Induces Oxidative-Stress-Mediated Apoptosis and DNA Damage

(2021) Tzu-Jung Yu et al.   Antioxidants

Oxidative Stress-Dependent Synergistic Antiproliferation, Apoptosis, and DNA Damage of Ultraviolet-C and Coral-Derived Sinularin Combined Treatment for Oral Cancer Cells

(2021) Sheng-Yao Peng et al.   Cancers

Involvement of Metabolic Lipid Mediators in the Regulation of Apoptosis

(2020) Piotr Wójcik et al.   Biomolecules

Roles and Functions of ROS and RNS in Cellular Physiology and Pathology

(2020) Neven Zarkovic   Cells

Low Concentration of Withaferin a Inhibits Oxidative Stress-Mediated Migration and Invasion in Oral Cancer Cells

(2020) Tzu-Jung Yu et al.   Biomolecules

Combined Treatment with Low Cytotoxic Ethyl Acetate Nepenthes Extract and Ultraviolet-C Improves Antiproliferation to Oral Cancer Cells via Oxidative Stress

(2020) Sheng-Yao Peng et al.   Antioxidants

The NRF2, Thioredoxin, and Glutathione System in Tumorigenesis and Anticancer Therapies

(2020) Morana Jaganjac et al.   Antioxidants

Regulatory effects of noncoding RNAs on the interplay of oxidative stress and autophagy in cancer malignancy and therapy

(2020) Pei-Feng Liu et al.   SEMINARS IN CANCER BIOLOGY

Withaferin A-mediated apoptosis in breast cancer cells is associated with alterations in mitochondrial dynamics

(2019) Anuradha Sehrawat et al.   MITOCHONDRION

Impeding the single-strand annealing pathway of DNA double-strand break repair by withaferin A-mediated FANCA degradation

(2019) Wenjun Liu et al.   DNA REPAIR

Identification of Withaferin A as a Potential Candidate for Anti-Cancer Therapy in Non-Small Cell Lung Cancer

(2019) Hsu et al.   Cancers

Reactive oxygen species-regulating proteins peroxiredoxin 2 and thioredoxin, and glyceraldehyde-3-phosphate dehydrogenase are differentially abundant in induced sputum from smokers with lung cancer or asbestos exposure

(2019) Annina M. Rostila et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4‐ATF3‐CHOP axis

(2019) Qin Tang et al.   CELL PROLIFERATION

Understanding of ROS-Inducing Strategy in Anticancer Therapy

(2019) Su Ji Kim et al.   Oxidative Medicine and Cellular Longevity

Withaferin A induces apoptosis by ROS-dependent mitochondrial dysfunction in human colorectal cancer cells

(2018) Shuxian Xia et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Increased lipid peroxidation, apoptosis and selective cytotoxicity in colon cancer cell line LoVo and its doxorubicin-resistant subline LoVo/Dx in the presence of newly synthesized phenothiazine derivatives

(2018) Kamila Środa-Pomianek et al.   BIOMEDICINE & PHARMACOTHERAPY

Sinularin Selectively Kills Breast Cancer Cells Showing G2/M Arrest, Apoptosis, and Oxidative DNA Damage

(2018) Hurng-Wern Huang et al.   MOLECULES

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Withaferin A inhibits apoptosis via activated Akt-mediated inhibition of oxidative stress

(2018) Zheyi Yan et al.   LIFE SCIENCES

Oxidative stress-modulating drugs have preferential anticancer effects - involving the regulation of apoptosis, DNA damage, endoplasmic reticulum stress, autophagy, metabolism, and migration

(2018) Jen-Yang Tang et al.   SEMINARS IN CANCER BIOLOGY

Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods

(2018) J. Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Extracts from the Mediterranean Food Plants Carthamus lanatus, Cichorium intybus, and Cichorium spinosum Enhanced GSH Levels and Increased Nrf2 Expression in Human Endothelial Cells

(2018) Dimitrios Stagos et al.   Oxidative Medicine and Cellular Longevity

Cancer growth regulation by 4-hydroxynonenal

(2017) Ana Cipak Gasparovic et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive oxygen species mediate soft corals-derived sinuleptolide-induced antiproliferation and DNA damage in oral cancer cells

(2017) Yung-Ting Chang et al.   OncoTargets and Therapy

Withaferin A inhibits the proliferation of gastric cancer cells by inducing G2/M cell cycle arrest and apoptosis

(2017) Green Kim et al.   Oncology Letters

Withaferin A Induces Oxidative Stress-Mediated Apoptosis and DNA Damage in Oral Cancer Cells

(2017) Hsueh-Wei Chang et al.   Frontiers in Physiology

4-Hydroxy-2-nonenal: a critical target in oxidative stress?

(2016) Mason Breitzig et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Antiproliferation of Cryptocarya concinna-derived cryptocaryone against oral cancer cells involving apoptosis, oxidative stress, and DNA damage

(2016) Hsun-Shuo Chang et al.   BMC Complementary and Alternative Medicine

Withaferin A suppresses the growth of myelodysplasia and leukemia cell lines by inhibiting cell cycle progression

(2016) Shuichiro Okamoto et al.   CANCER SCIENCE

Tenuifolide B from Cinnamomum tenuifolium Stem Selectively Inhibits Proliferation of Oral Cancer Cells via Apoptosis, ROS Generation, Mitochondrial Depolarization, and DNA Damage

(2016) Chung-Yi Chen et al.   Toxins

Withaferin A protects against palmitic acid-induced endothelial insulin resistance and dysfunction through suppression of oxidative stress and inflammation

(2016) Kalaivani Batumalaie et al.   Scientific Reports

Synergistic antitumor activity of withaferin A combined with oxaliplatin triggers reactive oxygen species-mediated inactivation of the PI3K/AKT pathway in human pancreatic cancer cells

(2015) Xu Li et al.   CANCER LETTERS

Antiproliferation potential of withaferin A on human osteosarcoma cells via the inhibition of G2/M checkpoint proteins

(2015) TING-ZHUO LV et al.   Experimental and Therapeutic Medicine

NQO1 Suppresses NF- B-p300 Interaction to Regulate Inflammatory Mediators Associated with Prostate Tumorigenesis

(2014) D. Thapa et al.   CANCER RESEARCH

Withaferin A induces apoptosis through the generation of thiol oxidation in human head and neck cancer cells

(2014) JONG WON PARK et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Marine algal natural products with anti-oxidative, anti-inflammatory, and anti-cancer properties

(2013) Jin-Ching Lee et al.   Cancer Cell International

Withaferin A, a Steroidal Lactone from Withania somnifera, Induces Mitotic Catastrophe and Growth Arrest in Prostate Cancer Cells

(2013) Ram V. Roy et al.   JOURNAL OF NATURAL PRODUCTS

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Golden Berry-Derived 4β-hydroxywithanolide E for Selectively Killing Oral Cancer Cells by Generating ROS, DNA Damage, and Apoptotic Pathways

(2013) Chien-Chih Chiu et al.   PLoS One

Flow Cytometric Quantification of All Phases of the Cell Cycle and Apoptosis in a Two-Color Fluorescence Plot

(2013) Christine Vignon et al.   PLoS One

Evaluating the performance of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 as the potential biomarkers of oral squamous cell carcinoma (OSCC)

(2012) Ching-Yu Yen et al.   BIOMARKERS

Anti-proliferative effect of methanolic extract of Gracilaria tenuistipitata on oral cancer cells involves apoptosis, DNA damage, and oxidative stress

(2012) Chi-Chen Yeh et al.   BMC Complementary and Alternative Medicine

Antiproliferation and Induction of Apoptosis in Ca9-22 Oral Cancer Cells by Ethanolic Extract of Gracilaria tenuistipitata

(2012) Chi-Chen Yeh et al.   MOLECULES

Effects of oxygen concentration on in vitro maturation of canine oocytes in a chemically defined serum-free medium

(2012) Mazdak Salavati et al.   REPRODUCTION

Down-regulation of estrogen receptor-alpha and rearranged during transfection tyrosine kinase is associated with withaferin a-induced apoptosis in MCF-7 breast cancer cells

(2011) Xuan Zhang et al.   BMC Complementary and Alternative Medicine

Withaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in human cervical cancer cells

(2011) R. Munagala et al.   CARCINOGENESIS

Withaferin A-Induced Apoptosis in Human Breast Cancer Cells Is Mediated by Reactive Oxygen Species

(2011) Eun-Ryeong Hahm et al.   PLoS One

Endoplasmic reticulum stress mediates withaferin A-induced apoptosis in human renal carcinoma cells

(2011) Min Jung Choi et al.   TOXICOLOGY IN VITRO

Redox Regulation in Cancer: A Double-edged Sword with Therapeutic Potential

(2010) Asha Acharya et al.   Oxidative Medicine and Cellular Longevity

Selective Killing of Cancer Cells by Ashwagandha Leaf Extract and Its Component Withanone Involves ROS Signaling

(2010) Nashi Widodo et al.   PLoS One

Withaferin A targets heat shock protein 90 in pancreatic cancer cells

(2009) Yanke Yu et al.   BIOCHEMICAL PHARMACOLOGY