Withaferin A suppresses the growth of myelodysplasia and leukemia cell lines by inhibiting cell cycle progression

Stress management by autophagy: Implications for chemoresistance

(2016) Zhao Huang et al.   INTERNATIONAL JOURNAL OF CANCER

Anti-cancer activity of withaferin A in B-cell lymphoma

(2015) MK McKenna et al.   CANCER BIOLOGY & THERAPY

Src/STAT3-dependent heme oxygenase-1 induction mediates chemoresistance of breast cancer cells to doxorubicin by promoting autophagy

(2015) Qixing Tan et al.   CANCER SCIENCE

Rigosertib induces cell death of a myelodysplastic syndrome-derived cell line by DNA damage-induced G2/M arrest

(2015) Tomoko Hyoda et al.   CANCER SCIENCE

Heme oxygenase-1 enhances autophagy in podocytes as a protective mechanism against high glucose-induced apoptosis

(2015) Chenglong Dong et al.   EXPERIMENTAL CELL RESEARCH

Anticancer activities ofWithania somnifera: Current research, formulations, and future perspectives

(2015) Mahendra Rai et al.   PHARMACEUTICAL BIOLOGY

Five-aza-2′-deoxycytidine-induced hypomethylation of cholesterol 25-hydroxylase gene is responsible for cell death of myelodysplasia/leukemia cells

(2015) Takayuki Tsujioka et al.   Scientific Reports

Withaferin A Induces Cell Death Selectively in Androgen-Independent Prostate Cancer Cells but Not in Normal Fibroblast Cells

(2015) Yukihiro Nishikawa et al.   PLoS One

Combined autophagy and proteasome inhibition

(2014) Dan T Vogl et al.   Autophagy

Autophagy Is a Survival Mechanism of Acute Myelogenous Leukemia Precursors during Dual mTORC2/mTORC1 Targeting

(2014) J. K. Altman et al.   CLINICAL CANCER RESEARCH

Oxidative cytotoxic agent withaferin A resensitizes temozolomide-resistant glioblastomas via MGMT depletion and induces apoptosis through Akt/mTOR pathway inhibitory modulation

(2014) Patrick T. Grogan et al.   INVESTIGATIONAL NEW DRUGS

Pharmacological Levels of Withaferin A (Withania somnifera) Trigger Clinically Relevant Anticancer Effects Specific to Triple Negative Breast Cancer Cells

(2014) Katarzyna Szarc vel Szic et al.   PLoS One

Molecular Targets and Mechanisms of Cancer Prevention and Treatment by Withaferin A, A Naturally Occurring Steroidal Lactone

(2013) Avani R. Vyas et al.   AAPS Journal

Autophagy Fails to Alter Withaferin A-Mediated Lethality in Human Breast Cancer Cells

(2013) Eun-Ryeong Hahm et al.   CURRENT CANCER DRUG TARGETS

Growth Arrest by the Antitumor Steroidal Lactone Withaferin A in Human Breast Cancer Cells Is Associated with Down-regulation and Covalent Binding at Cysteine 303 of β-Tubulin

(2013) Marie L. Antony et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Withaferin A, a Steroidal Lactone from Withania somnifera, Induces Mitotic Catastrophe and Growth Arrest in Prostate Cancer Cells

(2013) Ram V. Roy et al.   JOURNAL OF NATURAL PRODUCTS

Withaferin A inhibits experimental epithelial-mesenchymal transition in MCF-10A cells and suppresses vimentin protein level in vivo in breast tumors

(2013) Joomin Lee et al.   MOLECULAR CARCINOGENESIS

Heme Oxygenase-1 Prevents Cardiac Dysfunction in Streptozotocin-Diabetic Mice by Reducing Inflammation, Oxidative Stress, Apoptosis and Enhancing Autophagy

(2013) Yanli Zhao et al.   PLoS One

Counteracting Autophagy Overcomes Resistance to Everolimus in Mantle Cell Lymphoma

(2012) L. Rosich et al.   CLINICAL CANCER RESEARCH

Heme Oxygenase-1 in Tumor Biology and Therapy

(2012) Halina Was et al.   CURRENT DRUG TARGETS

Effects of DNA methyltransferase inhibitors (DNMTIs) on MDS-derived cell lines

(2012) Takayuki Tsujioka et al.   EXPERIMENTAL HEMATOLOGY

Randomized study of induction therapy comparing standard-dose idarubicin with high-dose daunorubicin in adult patients with previously untreated acute myeloid leukemia: the JALSG AML201 Study

(2010) S. Ohtake et al.   BLOOD

Lenalidomide induces cell death in an MDS-derived cell line with deletion of chromosome 5q by inhibition of cytokinesis

(2010) A Matsuoka et al.   LEUKEMIA

Many are called MDS cell lines: One is chosen

(2009) Hans G. Drexler et al.   LEUKEMIA RESEARCH

Induction of apoptosis by withaferin A in human leukemia U937 cells through down-regulation of Akt phosphorylation

(2008) Jung Hwa Oh et al.   APOPTOSIS

Ayurvedic Medicine Constituent Withaferin A Causes G2 and M Phase Cell Cycle Arrest in Human Breast Cancer Cells

(2008) Silvia D. Stan et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis

(2007) Kirsteen H. Maclean et al.   JOURNAL OF CLINICAL INVESTIGATION