Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4‐ATF3‐CHOP axis

Adaptive endoplasmic reticulum stress signalling via IRE1α–XBP1 preserves self-renewal of haematopoietic and pre-leukaemic stem cells

(2019) Lu Liu et al.   NATURE CELL BIOLOGY

The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress

(2019) Morten Luhr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clustering of IRE1α depends on sensing ER stress but not on its RNase activity

(2019) Daniela Ricci et al.   FASEB JOURNAL

p53-independent Noxa induction by cisplatin is regulated by ATF3/ATF4 in head and neck squamous cell carcinoma cells

(2018) Kanika Sharma et al.   Molecular Oncology

H6, a novel hederagenin derivative, reverses multidrug resistance in vitro and in vivo

(2018) Yanting Yang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

ER stress signaling has an activating transcription factor 6α (ATF6)-dependent “off-switch”

(2018) Franziska Walter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EGFR confers radioresistance in human oropharyngeal carcinoma by activating endoplasmic reticulum stress signaling PERK-eIF2α-GRP94 and IRE1α-XBP1-GRP78

(2018) Miao Zhang et al.   Cancer Medicine

Withaferin A inhibits the proliferation of gastric cancer cells by inducing G2/M cell cycle arrest and apoptosis

(2017) Green Kim et al.   Oncology Letters

Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivo

(2017) Guangyao Lv et al.   Acta Pharmaceutica Sinica B

Activating Transcription Factor 4 (ATF4)-ATF3-C/EBP Homologous Protein (CHOP) Cascade Shows an Essential Role in the ER Stress-Induced Sensitization of Tetrachlorobenzoquinone-Challenged PC12 Cells to ROS-Mediated Apoptosis via Death Receptor 5 (DR5) Signaling

(2016) Zixuan Liu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice

(2016) Jaemin Lee et al.   NATURE MEDICINE

Progress in glioma diagnosis, classification and treatment

(2016) Patrick Y. Wen et al.   Nature Reviews Neurology

Chaetocin induces endoplasmic reticulum stress response and leads to death receptor 5-dependent apoptosis in human non-small cell lung cancer cells

(2015) Xianfang Liu et al.   APOPTOSIS

Withaferin-A Reduces Acetaminophen-Induced Liver Injury in Mice

(2015) Ravirajsinh N. Jadeja et al.   BIOCHEMICAL PHARMACOLOGY

Anti-cancer activity of withaferin A in B-cell lymphoma

(2015) MK McKenna et al.   CANCER BIOLOGY & THERAPY

Antiproliferation potential of withaferin A on human osteosarcoma cells via the inhibition of G2/M checkpoint proteins

(2015) TING-ZHUO LV et al.   Experimental and Therapeutic Medicine

Axl is a novel target of withaferin A in the induction of apoptosis and the suppression of invasion

(2014) Seon Min Woo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of ATF3 in synergistic cancer cell killing by a combination of HDAC inhibitors and agonistic anti-DR5 antibody through ER stress in human colon cancer cells

(2014) Jia Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of Activating Transcription Factor 3 (ATF3) in Endoplasmic Reticulum (ER) Stress-induced Sensitization of p53-deficient Human Colon Cancer Cells to Tumor Necrosis Factor (TNF)-related Apoptosis-inducing Ligand (TRAIL)-mediated Apoptosis through Up-regulation of Death Receptor 5 (DR5) by Zerumbone and Celecoxib

(2014) Makoto Edagawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Withaferin A, a Steroidal Lactone from Withania somnifera, Induces Mitotic Catastrophe and Growth Arrest in Prostate Cancer Cells

(2013) Ram V. Roy et al.   JOURNAL OF NATURAL PRODUCTS

Metabolic Alterations in Mammary Cancer Prevention by Withaferin A in a Clinically Relevant Mouse Model

(2013) Eun-Ryeong Hahm et al.   JNCI-Journal of the National Cancer Institute

Caspase Functions in Cell Death and Disease

(2013) D. R. McIlwain et al.   Cold Spring Harbor Perspectives in Biology

Pharmacological targeting of endoplasmic reticulum stress signaling in cancer

(2012) Axel H. Schönthal   BIOCHEMICAL PHARMACOLOGY

Withaferin A-induced apoptosis in human breast cancer cells is associated with suppression of inhibitor of apoptosis family protein expression

(2012) Eun-Ryeong Hahm et al.   CANCER LETTERS

BCL2 Suppresses PARP1 Function and Nonapoptotic Cell Death

(2012) Chaitali Dutta et al.   CANCER RESEARCH

Withaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in human cervical cancer cells

(2011) R. Munagala et al.   CARCINOGENESIS

Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation

(2011) Jose T. Thaiparambil et al.   INTERNATIONAL JOURNAL OF CANCER

Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control

(2011) M. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic reticulum stress mediates withaferin A-induced apoptosis in human renal carcinoma cells

(2011) Min Jung Choi et al.   TOXICOLOGY IN VITRO

Survival of Patients with Newly Diagnosed Glioblastoma Treated with Radiation and Temozolomide in Research Studies in the United States

(2010) S. A. Grossman et al.   CLINICAL CANCER RESEARCH

Notch-1 Inhibition by Withaferin-A: A Therapeutic Target against Colon Carcinogenesis

(2010) S. Koduru et al.   MOLECULAR CANCER THERAPEUTICS

Withaferin A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP

(2009) Tae-Jin Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Withaferin A Causes FOXO3a- and Bim-Dependent Apoptosis and Inhibits Growth of Human Breast Cancer Cells In vivo

(2008) S. D. Stan et al.   CANCER RESEARCH

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ayurvedic Medicine Constituent Withaferin A Causes G2 and M Phase Cell Cycle Arrest in Human Breast Cancer Cells

(2008) Silvia D. Stan et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL