Design and Evaluation of Synthetic RNA-Based Incoherent Feed-Forward Loop Circuits

Model-guided design of mammalian genetic programs

(2021) J. J. Muldoon et al.   Science Advances

Multilevel Gene Regulation Using Switchable Transcription Terminator and Toehold Switch in Escherichia coli

(2021) Seongho Hong et al.   Applied Sciences-Basel

Multistable and dynamic CRISPRi-based synthetic circuits

(2020) Javier Santos-Moreno et al.   Nature Communications

Genetic circuit design automation for yeast

(2020) Ye Chen et al.   Nature Microbiology

Characterization and mitigation of gene expression burden in mammalian cells

(2020) Timothy Frei et al.   Nature Communications

How Retroactivity Affects the Behavior of Incoherent Feedforward Loops

(2020) Junmin Wang et al.   iScience

Distinct timescales of RNA regulators enable the construction of a genetic pulse generator

(2019) Alexandra Westbrook et al.   BIOTECHNOLOGY AND BIOENGINEERING

The engineering principles of combining a transcriptional incoherent feedforward loop with negative feedback

(2019) Gregory T. Reeves   Journal of Biological Engineering

Cell-Free Prototyping of AND-Logic Gates Based on Heterogeneous RNA Activators

(2019) François-Xavier Lehr et al.   ACS Synthetic Biology

De novo-designed translation-repressing riboregulators for multi-input cellular logic

(2019) Jongmin Kim et al.   Nature Chemical Biology

Recent developments in synthetic biology and metabolic engineering in microalgae towards biofuel production

(2018) Sheeja Jagadevan et al.   Biotechnology for Biofuels

Engineered promoters enable constant gene expression at any copy number in bacteria

(2018) Thomas H Segall-Shapiro et al.   NATURE BIOTECHNOLOGY

Engineering a Functional Small RNA Negative Autoregulation Network with Model-Guided Design

(2018) Chelsea Y. Hu et al.   ACS Synthetic Biology

Predicting Transcriptional Output of Synthetic Multi-input Promoters

(2018) David M. Zong et al.   ACS Synthetic Biology

Complex cellular logic computation using ribocomputing devices

(2017) Alexander A. Green et al.   NATURE

Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells

(2017) Benjamin H Weinberg et al.   NATURE BIOTECHNOLOGY

Computational design of small transcription activating RNAs for versatile and dynamic gene regulation

(2017) James Chappell et al.   Nature Communications

The Timing of Transcriptional Regulation in Synthetic Gene Circuits

(2017) Yu-Yu Cheng et al.   ACS Synthetic Biology

Genetic circuit design automation

(2016) A. A. K. Nielsen et al.   SCIENCE

A renaissance in RNA synthetic biology: new mechanisms, applications and tools for the future

(2015) James Chappell et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Creating small transcription activating RNAs

(2015) James Chappell et al.   Nature Chemical Biology

Toehold Switches: De-Novo-Designed Regulators of Gene Expression

(2014) Alexander A. Green et al.   CELL

A brief history of synthetic biology

(2014) D. Ewen Cameron et al.   NATURE REVIEWS MICROBIOLOGY

Synthetic circuit for exact adaptation and fold-change detection

(2014) Jongmin Kim et al.   NUCLEIC ACIDS RESEARCH

Environmental Sensing of Heavy Metals Through Whole Cell Microbial Biosensors: A Synthetic Biology Approach

(2014) Lara Tess Bereza-Malcolm et al.   ACS Synthetic Biology

Initiation of mRNA decay in bacteria

(2013) Soumaya Laalami et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Utility of Paradoxical Components in Biological Circuits

(2013) Yuval Hart et al.   MOLECULAR CELL

Genomic mining of prokaryotic repressors for orthogonal logic gates

(2013) Brynne C Stanton et al.   Nature Chemical Biology

Functional Roles of Pulsing in Genetic Circuits

(2013) J. H. Levine et al.   SCIENCE

Implementation of half adder and half subtractor with a simple and universal DNA-based platform

(2013) Shanling Xu et al.   NPG Asia Materials

Synthetic Biology: An Emerging Engineering Discipline

(2012) Allen A. Cheng et al.   Annual Review of Biomedical Engineering

Ribozyme-based insulator parts buffer synthetic circuits from genetic context

(2012) Chunbo Lou et al.   NATURE BIOTECHNOLOGY

De novo automated design of small RNA circuits for engineering synthetic riboregulation in living cells

(2012) G. Rodrigo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A synchronized quorum of genetic clocks

(2010) Tal Danino et al.   NATURE