Profilin Isoforms in Health and Disease – All the Same but Different
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Profilin Isoforms in Health and Disease – All the Same but Different
Authors
Keywords
-
Journal
Frontiers in Cell and Developmental Biology
Volume 9, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-08-12
DOI
10.3389/fcell.2021.681122
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Profilin2 regulates actin rod assembly in neuronal cells
- (2021) Lisa Marie Walter et al. Scientific Reports
- Promoting Neuronal Outgrowth Using Ridged Scaffolds Coated with Extracellular Matrix Proteins
- (2021) Ahad M. Siddiqui et al. Biomedicines
- ALS-linked PFN1 variants exhibit loss and gain of functions in the context of formin-induced actin polymerization
- (2021) Eric J. Schmidt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Loss of Profilin 1 Causes Early Onset Paget's Disease of Bone
- (2020) Federica Scotto di Carlo et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Abrogation of prenucleation, transient oligomerization of the Huntingtin exon 1 protein by human profilin I
- (2020) Alberto Ceccon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Arp2/3 and Mena/VASP Require Profilin 1 for Actin Network Assembly at the Leading Edge
- (2020) Kristen Skruber et al. CURRENT BIOLOGY
- Mutation of PFN1 gene in an early onset, polyostotic Paget's-like disease
- (2020) Daniela Merlotti et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Profilin 1 delivery tunes cytoskeletal dynamics toward CNS axon regeneration
- (2020) Rita Pinto-Costa et al. JOURNAL OF CLINICAL INVESTIGATION
- Detergent‐insoluble inclusion constitutes the first pathology in PFN1 transgenic rats
- (2020) Guixiu Yuan et al. JOURNAL OF NEUROCHEMISTRY
- Axon Growth of CNS Neurons in Three Dimensions Is Amoeboid and Independent of Adhesions
- (2020) Telma E. Santos et al. Cell Reports
- The role of TDP-43 mislocalization in amyotrophic lateral sclerosis
- (2020) Terry R. Suk et al. Molecular Neurodegeneration
- A Synaptic Perspective of Fragile X Syndrome and Autism Spectrum Disorders
- (2019) Claudia Bagni et al. NEURON
- The next generation of CRISPR–Cas technologies and applications
- (2019) Adrian Pickar-Oliver et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- How internal cavities destabilize a protein
- (2019) Mengjun Xue et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genes and Mechanisms Involved in the Generation and Amplification of Basal Radial Glial Cells
- (2019) Maxime Penisson et al. Frontiers in Cellular Neuroscience
- Developmental Expression of Mutant PFN1 in Motor Neurons Impacts Neuronal Growth and Motor Performance of Young and Adult Mice
- (2019) Merryn Brettle et al. Frontiers in Molecular Neuroscience
- Modulation of actin polymerization affects nucleocytoplasmic transport in multiple forms of amyotrophic lateral sclerosis
- (2019) Anthony Giampetruzzi et al. Nature Communications
- Profilin and formin constitute a pacemaker system for robust actin filament growth
- (2019) Johanna Funk et al. eLife
- Profilin1-Dependent F-Actin Assembly Controls Division of Apical Radial Glia and Neocortex Development
- (2019) Jan A Kullmann et al. CEREBRAL CORTEX
- Profilin2a‐phosphorylation as a regulatory mechanism for actin dynamics
- (2019) Lisa Marie Walter et al. FASEB JOURNAL
- Stability of an aggregation-prone partially folded state of human profilin-1 correlates with aggregation propensity
- (2018) Edoardo Del Poggetto et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers
- (2018) Ammon E. Posey et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of actin dynamics during structural plasticity of dendritic spines: Signaling messengers and actin-binding proteins
- (2018) Jelena Borovac et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Important Shapeshifter: Mechanisms Allowing Astrocytes to Respond to the Changing Nervous System During Development, Injury and Disease
- (2018) Juliane Schiweck et al. Frontiers in Cellular Neuroscience
- RNA-Seq Analysis of Spinal Cord Tissues from hPFN1G118V Transgenic Mouse Model of ALS at Pre-symptomatic and End-Stages of Disease
- (2018) Caroline Barham et al. Scientific Reports
- Evolutionary expansion and structural functionalism of the ancient family of profilin proteins
- (2017) Dhananjay K. Pandey et al. GENE
- A Fluorophore Fusion Construct of Human Profilin I with Non-Compromised Poly(L-Proline) Binding Capacity Suitable for Imaging
- (2017) Michaela Nejedla et al. JOURNAL OF MOLECULAR BIOLOGY
- Distinct VASP tetramers synergize in the processive elongation of individual actin filaments from clustered arrays
- (2017) Stefan Brühmann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Biophysical analysis of three novel profilin-1 variants associated with amyotrophic lateral sclerosis indicates a correlation between their aggregation propensity and the structural features of their globular state
- (2016) Edoardo Del Poggetto et al. BIOLOGICAL CHEMISTRY
- Profilin1 biology and its mutation, actin(g) in disease
- (2016) Duah Alkam et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Profilin Interaction with Actin Filament Barbed End Controls Dynamic Instability, Capping, Branching, and Motility
- (2016) Julien Pernier et al. DEVELOPMENTAL CELL
- Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease
- (2016) Daniel Fil et al. HUMAN MOLECULAR GENETICS
- Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregation
- (2016) Yoshinori Tanaka et al. HUMAN MOLECULAR GENETICS
- Familial Amyotrophic Lateral Sclerosis-linked Mutations inProfilin 1Exacerbate TDP-43-induced Degeneration in the Retina ofDrosophila melanogasterthrough an Increase in the Cytoplasmic Localization of TDP-43
- (2016) Koji Matsukawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Profilin connects actin assembly with microtubule dynamics
- (2016) Michaela Nejedla et al. MOLECULAR BIOLOGY OF THE CELL
- The Biology of Huntingtin
- (2016) Frédéric Saudou et al. NEURON
- Neuronal profilins in health and disease: Relevance for spine plasticity and Fragile X syndrome
- (2016) Kristin Michaelsen-Preusse et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mutant PFN1 causes ALS phenotypes and progressive motor neuron degeneration in mice by a gain of toxicity
- (2016) Chunxing Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mutations of Profilin-1 Associated with Amyotrophic Lateral Sclerosis Promote Aggregation Due to Structural Changes of Its Native State
- (2015) Edoardo Del Poggetto et al. ACS Chemical Biology
- Profilin 1 with the amyotrophic lateral sclerosis associated mutation T109M displays unaltered actin binding and does not affect the actin cytoskeleton
- (2015) Axel Freischmidt et al. BMC NEUROSCIENCE
- Profilin-1 Serves as a Gatekeeper for Actin Assembly by Arp2/3-Dependent and -Independent Pathways
- (2015) Jeremy D. Rotty et al. DEVELOPMENTAL CELL
- Profilin Regulates F-Actin Network Homeostasis by Favoring Formin over Arp2/3 Complex
- (2015) Cristian Suarez et al. DEVELOPMENTAL CELL
- Rho Kinase Pathway Alterations in the Brain and Leukocytes in Huntington’s Disease
- (2015) K. Lakshmi Narayanan et al. MOLECULAR NEUROBIOLOGY
- Novel mutations support a role for Profilin 1 in the pathogenesis of ALS
- (2015) Bradley N. Smith et al. NEUROBIOLOGY OF AGING
- Neuropathology of Amyotrophic Lateral Sclerosis and Its Variants
- (2015) Shahram Saberi et al. NEUROLOGIC CLINICS
- Spinal Muscular Atrophy
- (2015) Stephen J. Kolb et al. NEUROLOGIC CLINICS
- Structural basis for mutation-induced destabilization of profilin 1 in ALS
- (2015) Sivakumar Boopathy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Folding process of Human Profilin-1, a novel protein associated with familial amyotrophic lateral sclerosis
- (2015) Edoardo Del Poggetto et al. Scientific Reports
- Profilin Isoforms Modulate Astrocytic Morphology and the Motility of Astrocytic Processes
- (2015) Stefanie K. Schweinhuber et al. PLoS One
- The Role of Arp2/3 in Growth Cone Actin Dynamics and Guidance Is Substrate Dependent
- (2014) J. E. San Miguel-Ruiz et al. JOURNAL OF NEUROSCIENCE
- Profilin 1 Associates with Stress Granules and ALS-Linked Mutations Alter Stress Granule Dynamics
- (2014) M. D. Figley et al. JOURNAL OF NEUROSCIENCE
- Ena/VASP Enabled is a highly processive actin polymerase tailored to self-assemble parallel-bundled F-actin networks with Fascin
- (2014) J. D. Winkelman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Profilin1 activity in cerebellar granule neurons is required for radial migrationin vivo
- (2014) Jan A Kullmann et al. Cell Adhesion & Migration
- Interaction of Profilin with the Barbed End of Actin Filaments
- (2013) Naomi Courtemanche et al. BIOCHEMISTRY
- Calcium-induced outgrowth of astrocytic peripheral processes requires actin binding by Profilin-1
- (2013) Dmitry Molotkov et al. CELL CALCIUM
- Dynamic Localization of G-Actin during Membrane Protrusion in Neuronal Motility
- (2013) Chi Wai Lee et al. CURRENT BIOLOGY
- Formins at a glance
- (2013) Dennis Breitsprecher et al. JOURNAL OF CELL SCIENCE
- Profilin1 E117G is a moderate risk factor for amyotrophic lateral sclerosis
- (2013) P. Fratta et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- PFN1 mutations are rare in Han Chinese populations with amyotrophic lateral sclerosis
- (2013) YongPing Chen et al. NEUROBIOLOGY OF AGING
- Intravitreal Administration of HA-1077, a ROCK Inhibitor, Improves Retinal Function in a Mouse Model of Huntington Disease
- (2013) Mei Li et al. PLoS One
- The multifaceted role of profilin-1 in adipose tissue inflammation and glucose homeostasis
- (2013) Munkyong Pae et al. Adipocyte
- Spinal muscular atrophy: The role of SMN in axonal mRNA regulation
- (2012) Claudia Fallini et al. BRAIN RESEARCH
- Differential Remodeling of Actin Cytoskeleton Architecture by Profilin Isoforms Leads to Distinct Effects on Cell Migration and Invasion
- (2012) Ghassan Mouneimne et al. CANCER CELL
- Arp2/3 complex–dependent actin networks constrain myosin II function in driving retrograde actin flow
- (2012) Qing Yang et al. JOURNAL OF CELL BIOLOGY
- Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis
- (2012) Chi-Hong Wu et al. NATURE
- A novel phosphorylation site mutation in profilin 1 revealed in a large screen of US, Nordic, and German amyotrophic lateral sclerosis/frontotemporal dementia cohorts
- (2012) Caroline Ingre et al. NEUROBIOLOGY OF AGING
- Purkinje cell loss and motor coordination defects in profilin1 mutant mice
- (2012) J.A. Kullmann et al. NEUROSCIENCE
- Protein Phosphatase 1 Dephosphorylates Profilin-1 at Ser-137
- (2012) Jieya Shao et al. PLoS One
- Preserved Morphology and Physiology of Excitatory Synapses in Profilin1-Deficient Mice
- (2012) Andreas Görlich et al. PLoS One
- FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism
- (2011) Jennifer C. Darnell et al. CELL
- Profilin1 is required for glial cell adhesion and radial migration of cerebellar granule neurons
- (2011) Jan A Kullmann et al. EMBO REPORTS
- The spinal muscular atrophy disease protein SMN is linked to the rho-kinase pathway via profilin
- (2011) Anna Nölle et al. HUMAN MOLECULAR GENETICS
- FMRP Regulates the Transition from Radial Glial Cells to Intermediate Progenitor Cells during Neocortical Development
- (2011) R. Saffary et al. JOURNAL OF NEUROSCIENCE
- Individual Actin Filaments in a Microfluidic Flow Reveal the Mechanism of ATP Hydrolysis and Give Insight Into the Properties of Profilin
- (2011) Antoine Jégou et al. PLOS BIOLOGY
- VASP is a processive actin polymerase that requires monomeric actin for barbed end association
- (2010) Scott D. Hansen et al. JOURNAL OF CELL BIOLOGY
- Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease
- (2010) Chiara Zuccato et al. PHYSIOLOGICAL REVIEWS
- Fine-tuning of neuronal architecture requires two profilin isoforms
- (2010) K. Michaelsen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Should I stay or should I go? Becoming a granule cell
- (2010) Alain Chédotal TRENDS IN NEUROSCIENCES
- Structure, modifications and ligand-binding properties of rat profilin 2a
- (2009) Teemu Haikarainen et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Testis-expressed profilins 3 and 4 show distinct functional characteristics and localize in the acroplaxome-manchette complex in spermatids
- (2009) Martina Behnen et al. BMC CELL BIOLOGY
- Inhibition of Rho Kinases Enhances the Degradation of Mutant Huntingtin
- (2009) Peter O. Bauer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- In birds, profilin-2a is ubiquitously expressed and contributes to actin-based motility
- (2009) K. Murk et al. JOURNAL OF CELL SCIENCE
- Actin, a Central Player in Cell Shape and Movement
- (2009) T. D. Pollard et al. SCIENCE
- Drosophila fragile X mental retardation protein developmentally regulates activity-dependent axon pruning
- (2008) C. R. Tessier et al. DEVELOPMENT
- Clustering of VASP actively drives processive, WH2 domain-mediated actin filament elongation
- (2008) Dennis Breitsprecher et al. EMBO JOURNAL
- Phosphorylation of Profilin by ROCK1 Regulates Polyglutamine Aggregation
- (2008) J. Shao et al. MOLECULAR AND CELLULAR BIOLOGY
- Expression of expanded polyglutamine targets profilin for degradation and alters actin dynamics
- (2008) Barrington G. Burnett et al. NEUROBIOLOGY OF DISEASE
- The Role of the FH1 Domain and Profilin in Formin-Mediated Actin-Filament Elongation and Nucleation
- (2007) Aditya Paul et al. CURRENT BIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started