Developmental Expression of Mutant PFN1 in Motor Neurons Impacts Neuronal Growth and Motor Performance of Young and Adult Mice

Selective Spatiotemporal Vulnerability of Central Nervous System Neurons to Pathologic TAR DNA-Binding Protein 43 in Aged Transgenic Mice

(2018) Annika van Hummel et al.   AMERICAN JOURNAL OF PATHOLOGY

Hypermetabolism in ALS is associated with greater functional decline and shorter survival

(2018) Frederik J Steyn et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Novel genes associated with amyotrophic lateral sclerosis: diagnostic and clinical implications

(2018) Ruth Chia et al.   LANCET NEUROLOGY

Differential expression of genes identified by suppression subtractive hybridization in liver and adipose tissue of gerbils with diabetes

(2018) Jingjing Gong et al.   PLoS One

Actin–microtubule crosstalk in cell biology

(2018) Marileen Dogterom et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Life course body mass index and risk and prognosis of amyotrophic lateral sclerosis: results from the ALS registry Swabia

(2017) Raphael Simon Peter et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Generation of Genetically Modified Mice through the Microinjection of Oocytes

(2017) Fabien Delerue et al.   Jove-Journal of Visualized Experiments

Identification of microRNAs regulating Hlxb9 gene expression during the induction of insulin-producing cells

(2016) Changzheng Mu et al.   CELL BIOLOGY INTERNATIONAL

Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease

(2016) Daniel Fil et al.   HUMAN MOLECULAR GENETICS

Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregation

(2016) Yoshinori Tanaka et al.   HUMAN MOLECULAR GENETICS

Different roles of the small GTPases Rac1, Cdc42, and RhoG in CALEB/NGC-induced dendritic tree complexity

(2016) Jana Schulz et al.   JOURNAL OF NEUROCHEMISTRY

Profilin connects actin assembly with microtubule dynamics

(2016) Michaela Nejedla et al.   MOLECULAR BIOLOGY OF THE CELL

Mutant PFN1 causes ALS phenotypes and progressive motor neuron degeneration in mice by a gain of toxicity

(2016) Chunxing Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer’s mice

(2016) Arne Ittner et al.   SCIENCE

Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS

(2015) Yazi D. Ke et al.   ACTA NEUROPATHOLOGICA

SMN expression is required in motor neurons to rescue electrophysiological deficits in the SMNΔ7 mouse model of SMA

(2015) Vicki L. McGovern et al.   HUMAN MOLECULAR GENETICS

Rac1 plays an essential role in axon growth and guidance and in neuronal survival in the central and peripheral nervous systems

(2015) Zhong L. Hua et al.   Neural Development

Novel mutations support a role for Profilin 1 in the pathogenesis of ALS

(2015) Bradley N. Smith et al.   NEUROBIOLOGY OF AGING

Amyotrophic lateral sclerosis-associated mutant profilin 1 increases dendritic arborisation and spine formation in primary hippocampal neurons

(2015) Merryn Brettle et al.   NEUROSCIENCE LETTERS

Identification of genetic factors that modify motor performance and body weight using Collaborative Cross mice

(2015) Jian-Hua Mao et al.   Scientific Reports

Dissection of genetic factors associated with amyotrophic lateral sclerosis

(2014) Claire S. Leblond et al.   EXPERIMENTAL NEUROLOGY

Profilin1 activity in cerebellar granule neurons is required for radial migrationin vivo

(2014) Jan A Kullmann et al.   Cell Adhesion & Migration

Interaction of Profilin with the Barbed End of Actin Filaments

(2013) Naomi Courtemanche et al.   BIOCHEMISTRY

Dynamic Localization of G-Actin during Membrane Protrusion in Neuronal Motility

(2013) Chi Wai Lee et al.   CURRENT BIOLOGY

State of play in amyotrophic lateral sclerosis genetics

(2013) Alan E Renton et al.   NATURE NEUROSCIENCE

PFN1 mutations are rare in Han Chinese populations with amyotrophic lateral sclerosis

(2013) YongPing Chen et al.   NEUROBIOLOGY OF AGING

Embryonic alteration of motoneuronal morphology induces hyperexcitability in the mouse model of amyotrophic lateral sclerosis

(2013) Elodie Martin et al.   NEUROBIOLOGY OF DISEASE

Amyotrophic Lateral Sclerosis: An update for 2013 Clinical Features, Pathophysiology, Management and Therapeutic Trials

(2013) Paul Gordon et al.   Aging and Disease

Early presymptomatic cholinergic dysfunction in a murine model of amyotrophic lateral sclerosis

(2013) Caty Casas et al.   Brain and Behavior

Characterization of early pathogenesis in the SOD1G93Amouse model of ALS: part I, background and methods

(2013) Sharon Vinsant et al.   Brain and Behavior

Characterization of early pathogenesis in the SOD1G93Amouse model of ALS: part II, results and discussion

(2013) Sharon Vinsant et al.   Brain and Behavior

Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis

(2012) Chi-Hong Wu et al.   NATURE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

A novel phosphorylation site mutation in profilin 1 revealed in a large screen of US, Nordic, and German amyotrophic lateral sclerosis/frontotemporal dementia cohorts

(2012) Caroline Ingre et al.   NEUROBIOLOGY OF AGING

Growth Cone Travel in Space and Time: the Cellular Ensemble of Cytoskeleton, Adhesion, and Membrane

(2012) Eric A. Vitriol et al.   NEURON

Purkinje cell loss and motor coordination defects in profilin1 mutant mice

(2012) J.A. Kullmann et al.   NEUROSCIENCE

Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice

(2011) Lionel M. Igaz et al.   JOURNAL OF CLINICAL INVESTIGATION

Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB–mediated pathogenic pathways

(2011) Vivek Swarup et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glycine Receptor Channels in Spinal Motoneurons Are Abnormal in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

(2011) Q. Chang et al.   JOURNAL OF NEUROSCIENCE

Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis

(2010) Brian C. Kraemer et al.   ACTA NEUROPATHOLOGICA

Prognostic factors in ALS: A critical review

(2009) Adriano Chiò et al.   Amyotrophic Lateral Sclerosis

Control of the Ability of Profilin to Bind and Facilitate Nucleotide Exchange from G-actin

(2008) Kuo-Kuang Wen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2008) J. Sreedharan et al.   SCIENCE