A high-affinity human TCR-like antibody detects celiac disease gluten peptide–MHC complexes and inhibits T cell activation

B lymphocytes contribute to celiac disease pathogenesis

(2021) Thomas Lejeune et al.   GASTROENTEROLOGY

Comprehensive Analysis of CDR3 Sequences in Gluten-Specific T-Cell Receptors Reveals a Dominant R-Motif and Several New Minor Motifs

(2021) Shiva Dahal-Koirala et al.   Frontiers in Immunology

Specificity of bispecific T cell receptors and antibodies targeting peptide-HLA

(2020) Christopher J. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

Ancestral Wheat Types Release Fewer Celiac Disease Related T Cell Epitopes than Common Wheat upon Ex Vivo Human Gastrointestinal Digestion

(2020) Tora Asledottir et al.   Foods

Coeliac disease

(2019) Katri Lindfors et al.   Nature Reviews Disease Primers

B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2

(2019) M. Fleur du Pré et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease

(2019) Jan Petersen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Disease-driving CD4+ T cell clonotypes persist for decades in celiac disease

(2018) Louise F. Risnes et al.   JOURNAL OF CLINICAL INVESTIGATION

Genome mapping of seed-borne allergens and immunoresponsive proteins in wheat

(2018) Angéla Juhász et al.   Science Advances

Plasma Cells are the Most Abundant Gluten Peptide MHC-expressing Cells in Inflamed Intestinal Tissues From Patients With Celiac Disease

(2018) Lene Støkken Høydahl et al.   GASTROENTEROLOGY

Antibody-secreting plasma cells persist for decades in human intestine

(2017) Ole J.B. Landsverk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Modeling and docking of antibody structures with Rosetta

(2017) Brian D Weitzner et al.   Nature Protocols

Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease

(2017) Romain Bouziat et al.   SCIENCE

Accurate Structure Prediction of CDR H3 Loops Enabled by a Novel Structure-Based C-Terminal Constraint

(2016) Brian D. Weitzner et al.   JOURNAL OF IMMUNOLOGY

Improved prediction of antibody VL–VHorientation

(2016) Nicholas A. Marze et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Multivalent pIX phage display selects for distinct and improved antibody properties

(2016) Lene S. Høydahl et al.   Scientific Reports

T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules

(2015) Jamie Rossjohn et al.   Annual Review of Immunology

Generation of MANAbodies specific to HLA-restricted epitopes encoded by somatically mutated genes

(2015) Andrew D. Skora et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Refractory celiac disease

(2015) Abdul R. Rishi et al.   Expert Review of Gastroenterology & Hepatology

Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology

(2014) Jonas F Ludvigsson et al.   GUT

Complexes of Two Cohorts of CLIP Peptides and HLA-DQ2 of the Autoimmune DR3-DQ2 Haplotype Are Poor Substrates for HLA-DM

(2014) L.-E. Fallang et al.   JOURNAL OF IMMUNOLOGY

T-cell receptor recognition of HLA-DQ2–gliadin complexes associated with celiac disease

(2014) Jan Petersen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes

(2014) L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restricted VH/VL usage and limited mutations in gluten-specific IgA of coeliac disease lesion plasma cells

(2014) Øyvind Steinsbø et al.   Nature Communications

Direct cloning and tetramer staining to measure the frequency of intestinal gluten-reactive T cells in celiac disease

(2013) Michael Bodd et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Antigen-specific immunomodulation for type 1 diabetes by novel recombinant antibodies directed against diabetes-associates auto-reactive T cell epitope

(2013) Rony Dahan et al.   JOURNAL OF AUTOIMMUNITY

CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery

(2013) Brian J Fennell et al.   mAbs

Chaperone-assisted thermostability engineering of a soluble T cell receptor using phage display

(2013) Kristin S. Gunnarsen et al.   Scientific Reports

TCR Gene Transfer: MAGE-C2/HLA-A2 and MAGE-A3/HLA-DP4 Epitopes as Melanoma-Specific Immune Targets

(2012) Trudy Straetemans et al.   Clinical & Developmental Immunology

Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules

(2012) Ludvig M. Sollid et al.   IMMUNOGENETICS

High abundance of plasma cells secreting transglutaminase 2–specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions

(2012) Roberto Di Niro et al.   NATURE MEDICINE

DeltaPhage—a novel helper phage for high-valence pIX phagemid display

(2012) Nicolay R. Nilssen et al.   NUCLEIC ACIDS RESEARCH

Rapid Accumulation of CD14+CD11c+ Dendritic Cells in Gut Mucosa of Celiac Disease after in vivo Gluten Challenge

(2012) Ann-Christin Røberg Beitnes et al.   PLoS One

Integration of Genetic and Immunological Insights into a Model of Celiac Disease Pathogenesis

(2011) Valérie Abadie et al.   Annual Review of Immunology

Posttranslational Modification of Gluten Shapes TCR Usage in Celiac Disease

(2011) S.-W. Qiao et al.   JOURNAL OF IMMUNOLOGY

Expanding the Versatility of Phage Display II: Improved Affinity Selection of Folded Domains on Protein VII and IX of the Filamentous Phage

(2011) Geir Åge Løset et al.   PLoS One

Expanding the Versatility of Phage Display I: Efficient Display of Peptide-Tags on Protein VII of the Filamentous Phage

(2011) Geir Åge Løset et al.   PLoS One

Density of CD163+CD11c+ Dendritic Cells Increases and CD103+ Dendritic Cells Decreases in the Coeliac Lesion

(2011) A.-C. R. Beitnes et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Integration, scaling, space-group assignment and post-refinement

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Periplasmic expression of soluble single chain T cell receptors is rescued by the chaperone FkpA

(2010) Kristin S Gunnarsen et al.   BMC BIOTECHNOLOGY

Comprehensive, Quantitative Mapping of T Cell Epitopes in Gluten in Celiac Disease

(2010) J. A. Tye-Din et al.   Science Translational Medicine

SnugDock: Paratope Structural Optimization during Antibody-Antigen Docking Compensates for Errors in Antibody Homology Models

(2010) Aroop Sircar et al.   PLoS Computational Biology

Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation

(2009) Lars-Egil Fallang et al.   NATURE IMMUNOLOGY

High-resolution, high-throughput HLA genotyping by next-generation sequencing

(2009) G. Bentley et al.   TISSUE ANTIGENS

Antitumor Activity of Immunotoxins with T-Cell Receptor-like Specificity against Human Melanoma Xenografts

(2008) E. Klechevsky et al.   CANCER RESEARCH