Journal
ONCOTARGET
Volume 6, Issue 13, Pages 10801-10811Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.2984
Keywords
female mammals; ovariectomy; life span; inflammation; estrogens
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Funding
- [NIH RO1-AF027713]
- [EU ERC-2012-ADG322977-Ways]
- [Health F2 2011 2778850]
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This study shows that lack of ovarian activity has a negative impact on the life span of female mice. The extent to which this phenomenon could be associated with the anti-inflammatory effect of estrogens was analyzed in metabolic organs and aorta, by quantitative analysis of mRNAs encoding proteins in the inflammatory cascade. We demonstrate that the TNF alpha, IL-1 beta, MCP-1, MIP-2 and IL-6 mRNA contents are increased in the liver, adipose tissue and aorta 7 months after ovariectomy (ovx) and this increased basal inflammation is maintained as the mice aged. In contrast, the extent of inflammatory gene expression is directly proportional to age in sham-operated mice. As a consequence, at 22 months, most of the inflammatory parameters examined were higher in the sham-operated group compared with the ovx group. These observations led us to propose that the decreased longevity of ovx mice may be due to an acceleration of the basal state of inflammation in metabolic organs, which is likely driven by the combination of a lack of estrogen-mediated anti-inflammatory activity and the loss of gonadal control of energy metabolism.
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