Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1194, Issue -, Pages 19-27Publisher
ELSEVIER
DOI: 10.1016/j.molstruc.2019.05.078
Keywords
Hinokitiol; Cyclodextrin; Metal complex; Molecular interaction; Electron spin resonance spectroscopy; Antimicrobial activity
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Objectives: The aim of the current study was to prepare a ternary complex of hinokitiol (HT), a metal ion (Cu (II)) and gamma-cyclodextrin (gamma CD) via coprecipitation and to assess its physicochemical properties and the effects of complexation on the antimicrobial activity of HT. Methods: Single-crystal X-ray structural analysis, powder X-ray diffraction (PXRD), near-infrared (NIR) absorption spectroscopy, and electron spin resonance (ESR) spectroscopy were performed to assess the complex in a solid state. Agar dilution was used to determine the minimum inhibitory concentration (MIC) of HT-Cu complex and the ternary inclusion complex with respect to Escherichia coli, Bacillus subtilis, Staphylococcus aureus, and Pseudomonas aeruginosa. Key findings: A ternary HT Cu/gamma CD inclusion complex formed as a result of coprecipitation. Results of an antimicrobial test revealed that the ternary HT-Cu/gamma CD inclusion complex had increased antimicrobial activity compared to that of HT alone. The level of antibacterial activity of ternary complex had action equivalent to that of an HT/gamma CD inclusion complex. Conclusions: The antimicrobial action of HT can presumably be capitalized on by including HT in CD without a metal in certain applications. The current results should provide a basis for use of hinokitiol as a human and environmentally friendly antimicrobial. (C) 2019 Elsevier B.V. All rights reserved.
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