Combining Photodynamic Therapy with Immunostimulatory Nanoparticles Elicits Effective Anti-Tumor Immune Responses in Preclinical Murine Models

Nano-herb medicine and PDT induced synergistic immunotherapy for colon cancer treatment

(2021) Xiaoli Wu et al.   BIOMATERIALS

Preclinical and Clinical Evidence of Immune Responses Triggered in Oncologic Photodynamic Therapy: Clinical Recommendations

(2020) Irati Beltrán Hernández et al.   Journal of Clinical Medicine

Sequential PDT and PTT Using Dual‐Modal Single‐Walled Carbon Nanohorns Synergistically Promote Systemic Immune Responses against Tumor Metastasis and Relapse

(2020) Jingxing Yang et al.   Advanced Science

Lack of myeloid cell infiltration as an acquired resistance strategy to immunotherapy

(2020) Elham Beyranvand Nejad et al.   Journal for ImmunoTherapy of Cancer

In Situ Dendritic Cell Vaccine for Effective Cancer Immunotherapy

(2019) Weijing Yang et al.   ACS Nano

Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death

(2019) Wei Li et al.   Nature Communications

Janus Nanobullets Combine Photodynamic Therapy and Magnetic Hyperthermia to Potentiate Synergetic Anti‐Metastatic Immunotherapy

(2019) Zheng Wang et al.   Advanced Science

Tumor‐Targeted Drug and CpG Delivery System for Phototherapy and Docetaxel‐Enhanced Immunotherapy with Polarization toward M1‐Type Macrophages on Triple Negative Breast Cancers

(2019) Lv Chen et al.   ADVANCED MATERIALS

Co-delivery of immunomodulators in biodegradable nanoparticles improves therapeutic efficacy of cancer vaccines

(2019) C.G. Da Silva et al.   BIOMATERIALS

The Course of Immune Stimulation by Photodynamic Therapy: Bridging Fundamentals of Photochemically Induced Immunogenic Cell Death to the Enrichment of T‐Cell Repertoire

(2019) Shubhankar Nath et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Photodynamic Therapy Combined with Antihypoxic Signaling and CpG Adjuvant as an In Situ Tumor Vaccine Based on Metal–Organic Framework Nanoparticles to Boost Cancer Immunotherapy

(2019) Zhixiong Cai et al.   Advanced Healthcare Materials

Identification of a neo-epitope dominating endogenous CD8 T cell responses to MC-38 colorectal cancer

(2019) Brett J. Hos et al.   OncoImmunology

Smart Nanovesicle-Mediated Immunogenic Cell Death through Tumor Microenvironment Modulation for Effective Photodynamic Immunotherapy

(2019) Weijing Yang et al.   ACS Nano

Photodynamic cancer therapy enhances accumulation of nanoparticles in tumor-associated myeloid cells

(2019) Ruben V. Huis in 't Veld et al.   JOURNAL OF CONTROLLED RELEASE

Mechanisms of resistance to immune checkpoint inhibitors

(2018) Russell W Jenkins et al.   BRITISH JOURNAL OF CANCER

TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

(2018) Christopher B. Rodell et al.   Nature Biomedical Engineering

Enhancing Anti-PD-1/PD-L1 Immune Checkpoint Inhibitory Cancer Therapy by CD276-Targeted Photodynamic Ablation of Tumor Cells and Tumor Vasculature

(2018) Rui Bao et al.   MOLECULAR PHARMACEUTICS

Immunomodulation of the Tumor Microenvironment: Turn Foe Into Friend

(2018) Hanne Locy et al.   Frontiers in Immunology

Trial Watch: Toll-like receptor agonists in cancer immunotherapy

(2018) Melody Smith et al.   OncoImmunology

Photodynamic-Immune Checkpoint Therapy Eradicates Local and Distant Tumors by CD8 + T Cells

(2017) Jan Willem Kleinovink et al.   Cancer Immunology Research

Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions

(2017) Demian van Straten et al.   Cancers

Combinatorial prospects of nano-targeted chemoimmunotherapy

(2016) C.G. Da Silva et al.   BIOMATERIALS

Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11b+Ly6G+ intratumor myeloid cells through the TICAM-1 signaling pathway

(2016) Hiroaki Shime et al.   CELL DEATH AND DIFFERENTIATION

Expansion and Activation of CD103 + Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition

(2016) Hélène Salmon et al.   IMMUNITY

Effect of PLGA NP size on efficiency to target traumatic brain injury

(2016) Luis J. Cruz et al.   JOURNAL OF CONTROLLED RELEASE

Combine and conquer: challenges for targeted therapy combinations in early phase trials

(2016) Juanita S. Lopez et al.   Nature Reviews Clinical Oncology

Chemokine/chemokine receptor pair CCL20/CCR6 in human colorectal malignancy: An overview

(2016) Vilma Oliveira Frick   WORLD JOURNAL OF GASTROENTEROLOGY

Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy

(2016) Chunbai He et al.   Nature Communications

TLR7-based cancer immunotherapy decreases intratumoral myeloid-derived suppressor cells and blocks their immunosuppressive function

(2016) Thibaud Spinetti et al.   OncoImmunology

Combination of Photodynamic Therapy and Specific Immunotherapy Efficiently Eradicates Established Tumors

(2015) J. W. Kleinovink et al.   CLINICAL CANCER RESEARCH

Immune effects of R848: Evidences that suggest an essential role of TLR7/8-induced, Myd88- and NF-κB-dependent signaling in the antiviral immunity of Japanese flounder (Paralichthys olivaceus)

(2015) Zhi-xia Zhou et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Toll-like receptor 7/8 agonist, R848, exhibits antitumoral effects in a breast cancer model

(2015) TAO YIN et al.   Molecular Medicine Reports

Combination cancer immunotherapy and new immunomodulatory targets

(2015) Kathleen M. Mahoney et al.   NATURE REVIEWS DRUG DISCOVERY

Improvement of DC vaccine with ALA-PDT induced immunogenic apoptotic cells for skin squamous cell carcinoma

(2015) Jie Ji et al.   Oncotarget

Cross-Presentation of the Oncofetal Tumor Antigen 5T4 from Irradiated Prostate Cancer Cells--A Key Role for Heat-Shock Protein 70 and Receptor CD91

(2015) J. Salimu et al.   Cancer Immunology Research

PolyI:C-Induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector-Mediated Tumor Elimination In Vivo

(2015) R. Takemura et al.   Cancer Immunology Research

Recurrent Overexpression of c-IAP2 in EBV-Associated Nasopharyngeal Carcinomas: Critical Role in Resistance to Toll-like Receptor 3-Mediated Apoptosis

(2015) Luc Friboulet et al.   NEOPLASIA

TLR8 signaling enhances tumor immunity by preventing tumor-induced T-cell senescence

(2014) J. Ye et al.   EMBO Molecular Medicine

Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing

(2014) Mahesh Yadav et al.   NATURE

Rose Bengal Acetate PhotoDynamic Therapy (RBAc-PDT) Induces Exposure and Release of Damage-Associated Molecular Patterns (DAMPs) in Human HeLa Cells

(2014) Elisa Panzarini et al.   PLoS One

Efficient Induction of Antitumor Immunity by Synthetic Toll-like Receptor Ligand-Peptide Conjugates

(2014) G. G. Zom et al.   Cancer Immunology Research

Photodynamic therapy-mediated DC immunotherapy is highly effective for the inhibition of established solid tumors

(2012) Nam-Chul Jung et al.   CANCER LETTERS

dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8

(2012) Y Estornes et al.   CELL DEATH AND DIFFERENTIATION

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

(2012) Abhishek D Garg et al.   EMBO JOURNAL

Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors

(2012) H. Shime et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of potent anti-tumor responses while eliminating systemic side effects via liposome-anchored combinatorial immunotherapy

(2011) Brandon Kwong et al.   BIOMATERIALS

Anticancer function of polyinosinic-polycytidylic acid

(2011) Yu-sheng Cheng et al.   CANCER BIOLOGY & THERAPY

Multimodal Imaging of Nanovaccine Carriers Targeted to Human Dendritic Cells

(2011) Luis J. Cruz et al.   MOLECULAR PHARMACEUTICS

The Inflammatory Microenvironment in Colorectal Neoplasia

(2011) Mairi H. McLean et al.   PLoS One

Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier

(2011) Hirenkumar K. Makadia et al.   Polymers

Targeted PLGA nano- but not microparticles specifically deliver antigen to human dendritic cells via DC-SIGN in vitro

(2010) Luis J. Cruz et al.   JOURNAL OF CONTROLLED RELEASE

Human Plasmacytoid Dendritic Cells Phagocytose, Process, and Present Exogenous Particulate Antigen

(2010) J. Tel et al.   JOURNAL OF IMMUNOLOGY

Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells

(2009) A Weber et al.   CELL DEATH AND DIFFERENTIATION

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Toll-like receptor 3 triggers apoptosis of human prostate cancer cells through a PKC- -dependent mechanism

(2008) A. Paone et al.   CARCINOGENESIS