The Course of Immune Stimulation by Photodynamic Therapy: Bridging Fundamentals of Photochemically Induced Immunogenic Cell Death to the Enrichment of T‐Cell Repertoire

Cell death: a review of the major forms of apoptosis, necrosis and autophagy

(2019) Mark S D’Arcy   CELL BIOLOGY INTERNATIONAL

Cancer Cell‐targeted and Activatable Photoimmunotherapy Spares T Cells in a 3D Co‐culture Model

(2019) Eric M. Kercher et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Enhanced Cellular Ablation by Attenuating Hypoxia Status and Reprogramming Tumor-Associated Macrophages via NIR Light-Responsive Upconversion Nanocrystals

(2018) Xiangzhao Ai et al.   BIOCONJUGATE CHEMISTRY

Photodynamic activity of Temoporfin nanoparticles induces a shift to the M1-like phenotype in M2-polarized macrophages

(2018) Zhenxin Zhu et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

A preclinical model to investigate the role of surgically-induced inflammation in tumor responses to intraoperative photodynamic therapy

(2018) Richard W. Davis et al.   LASERS IN SURGERY AND MEDICINE

Cell Death Pathways Associated with Photodynamic Therapy: An Update

(2018) David Kessel et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Apoptosis, Paraptosis and Autophagy: Death and Survival Pathways Associated with Photodynamic Therapy

(2018) David Kessel   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Photochemical Internalization of Peptide Antigens Provides a Novel Strategy to Realize Therapeutic Cancer Vaccination

(2018) Markus Haug et al.   Frontiers in Immunology

EGFR-targeted liposomal nanohybrid cerasomes: theranostic function and immune checkpoint inhibition in a mouse model of colorectal cancer

(2018) Yuan Li et al.   Nanoscale

Enhancing Anti-PD-1/PD-L1 Immune Checkpoint Inhibitory Cancer Therapy by CD276-Targeted Photodynamic Ablation of Tumor Cells and Tumor Vasculature

(2018) Rui Bao et al.   MOLECULAR PHARMACEUTICS

Luminol Chemiluminescence Reports Photodynamic Therapy-Generated Neutrophil Activity In Vivo and Serves as a Biomarker of Therapeutic Efficacy

(2018) Richard W. Davis et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

A Combination of Visudyne and a Lipid-anchored Liposomal Formulation of Benzoporphyrin Derivative Enhances Photodynamic Therapy Efficacy in a 3D Model for Ovarian Cancer

(2018) Imran Rizvi et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Inhibition of lymphangiogenesis impairs antitumour effects of photodynamic therapy and checkpoint inhibitors in mice

(2017) Angelika Muchowicz et al.   EUROPEAN JOURNAL OF CANCER

Mass Spectrometry Profiling of HLA-Associated Peptidomes in Mono-allelic Cells Enables More Accurate Epitope Prediction

(2017) Jennifer G. Abelin et al.   IMMUNITY

Cell death and immunity in cancer: From danger signals to mimicry of pathogen defense responses

(2017) Abhishek D. Garg et al.   IMMUNOLOGICAL REVIEWS

Subcellular Targeting as a Determinant of the Efficacy of Photodynamic Therapy

(2017) David Kessel   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Effects of Combined Lysosomal and Mitochondrial Photodamage in a Non-small-Cell Lung Cancer Cell Line: The Role of Paraptosis

(2017) David Kessel et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

T cell receptor repertoire usage in cancer as a surrogate marker for immune responses

(2017) David Schrama et al.   Seminars in Immunopathology

Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses

(2017) Guangbao Yang et al.   Nature Communications

Regulation of PD-1/PD-L1 pathway and resistance to PD-1/PDL1 blockade

(2017) Jie Bai et al.   Oncotarget

Mismatch Repair Deficiency as a Predictive Biomarker for Immunotherapy Efficacy

(2017) Giulia Viale et al.   Biomed Research International

Radiotherapy and CTLA-4 Blockade Shape the TCR Repertoire of Tumor-Infiltrating T Cells

(2017) Nils-Petter Rudqvist et al.   Cancer Immunology Research

Photodynamic-Immune Checkpoint Therapy Eradicates Local and Distant Tumors by CD8 + T Cells

(2017) Jan Willem Kleinovink et al.   Cancer Immunology Research

Trial watch: Immunogenic cell death induction by anticancer chemotherapeutics

(2017) Abhishek D. Garg et al.   OncoImmunology

Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions

(2017) Demian van Straten et al.   Cancers

Calreticulin Expression in Human Non–Small Cell Lung Cancers Correlates with Increased Accumulation of Antitumor Immune Cells and Favorable Prognosis

(2016) Jitka Fucikova et al.   CANCER RESEARCH

The T-cell Receptor Repertoire Influences the Tumor Microenvironment and Is Associated with Survival in Aggressive B-cell Lymphoma

(2016) Colm Keane et al.   CLINICAL CANCER RESEARCH

The urgent need to recover MHC class I in cancers for effective immunotherapy

(2016) Federico Garrido et al.   CURRENT OPINION IN IMMUNOLOGY

Dynein Separately Partners with NDE1 and Dynactin To Orchestrate T Cell Focused Secretion

(2016) Shubhankar Nath et al.   JOURNAL OF IMMUNOLOGY

Photodynamic Therapy Mediated by Nontoxic Core–Shell Nanoparticles Synergizes with Immune Checkpoint Blockade To Elicit Antitumor Immunity and Antimetastatic Effect on Breast Cancer

(2016) Xiaopin Duan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chlorin-Based Nanoscale Metal–Organic Framework Systemically Rejects Colorectal Cancers via Synergistic Photodynamic Therapy and Checkpoint Blockade Immunotherapy

(2016) Kuangda Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Acid-Activatable Versatile Micelleplexes for PD-L1 Blockade-Enhanced Cancer Photodynamic Immunotherapy

(2016) Dangge Wang et al.   NANO LETTERS

Landscape of tumor-infiltrating T cell repertoire of human cancers

(2016) Bo Li et al.   NATURE GENETICS

Promotion of Proapoptotic Signals by Lysosomal Photodamage: Mechanistic Aspects and Influence of Autophagy

(2016) David Kessel et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

(2016) N. McGranahan et al.   SCIENCE

Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell–driven rejection of high-grade glioma

(2016) Abhishek D. Garg et al.   Science Translational Medicine

Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy

(2016) Chunbai He et al.   Nature Communications

Near infrared photoimmunotherapy with avelumab, an anti-programmed death-ligand 1 (PD-L1) antibody

(2016) Tadanobu Nagaya et al.   Oncotarget

Enhanced Anti-Tumor Efficacy through a Combination of Integrin αvβ6-Targeted Photodynamic Therapy and Immune Checkpoint Inhibition

(2016) Liquan Gao et al.   Theranostics

Boosting Tumor-Specific Immunity Using PDT

(2016) Nicole Maeding et al.   Cancers

Autophagic death probed by photodynamic therapy

(2015) David Kessel   Autophagy

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

Combination of Photodynamic Therapy and Specific Immunotherapy Efficiently Eradicates Established Tumors

(2015) J. W. Kleinovink et al.   CLINICAL CANCER RESEARCH

Immune Checkpoint Blockade in Cancer Therapy

(2015) Michael A. Postow et al.   JOURNAL OF CLINICAL ONCOLOGY

T-cell receptor profiling in cancer

(2015) Ilan Kirsch et al.   Molecular Oncology

Estimating T-cell repertoire diversity: limitations of classical estimators and a new approach

(2015) Daniel J. Laydon et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Autophagy, a major adaptation pathway shaping cancer cell death and anticancer immunity responses following photodynamic therapy

(2015) Abhishek D. Garg et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Apoptosis and associated phenomena as a determinants of the efficacy of photodynamic therapy

(2015) David Kessel   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

The impact of macrophage-cancer cell interaction on the efficacy of photodynamic therapy

(2015) Mladen Korbelik et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Promotion of Proapoptotic Signals by Lysosomal Photodamage

(2015) David Kessel et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

(2015) N. A. Rizvi et al.   SCIENCE

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Resistance to Antiangiogenic Therapy Is Associated with an Immunosuppressive Tumor Microenvironment in Metastatic Renal Cell Carcinoma

(2015) X.-D. Liu et al.   Cancer Immunology Research

Targeting Epigenetic Processes in Photodynamic Therapy-Induced Anticancer Immunity

(2015) Malgorzata Wachowska et al.   Frontiers in Oncology

Tumor response to mTHPC-mediated photodynamic therapy exhibits strong correlation with extracellular release of HSP70

(2015) Soumya Mitra et al.   LASERS IN SURGERY AND MEDICINE

Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma

(2014) Alexandra Snyder et al.   NEW ENGLAND JOURNAL OF MEDICINE

ER stress, autophagy and immunogenic cell death in photodynamic therapy-induced anti-cancer immune responses

(2014) Abhishek D. Garg et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Enhanced Efficacy of Photodynamic Therapy via a Sequential Targeting Protocol

(2014) David Kessel et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Rose Bengal Acetate PhotoDynamic Therapy (RBAc-PDT) Induces Exposure and Release of Damage-Associated Molecular Patterns (DAMPs) in Human HeLa Cells

(2014) Elisa Panzarini et al.   PLoS One

Improved Survival with T Cell Clonotype Stability After Anti-CTLA-4 Treatment in Cancer Patients

(2014) E. Cha et al.   Science Translational Medicine

A high M1/M2 ratio of tumor-associated macrophages is associated with extended survival in ovarian cancer patients

(2014) Meiying Zhang et al.   Journal of Ovarian Research

Physical modalities inducing immunogenic tumor cell death for cancer immunotherapy

(2014) Irena Adkins et al.   OncoImmunology

Controlling Natural Killer Cell Responses: Integration of Signals for Activation and Inhibition

(2013) Eric O. Long et al.   Annual Review of Immunology

Pathways of Antigen Processing

(2013) Janice S. Blum et al.   Annual Review of Immunology

Recent insights into the role of the PD-1/PD-L1 pathway in immunological tolerance and autoimmunity

(2013) Elena Gianchecchi et al.   AUTOIMMUNITY REVIEWS

ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death

(2013) Abhishek D. Garg et al.   Autophagy

Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer

(2013) Y Ino et al.   BRITISH JOURNAL OF CANCER

Inducers of immunogenic cancer cell death

(2013) Aleksandra M. Dudek et al.   CYTOKINE & GROWTH FACTOR REVIEWS

IL-17 Promotes Neutrophil Entry into Tumor-Draining Lymph Nodes following Induction of Sterile Inflammation

(2013) C. M. Brackett et al.   JOURNAL OF IMMUNOLOGY

Generation of an effective anti-lung cancer vaccine by DTPP-mediated photodynamic therapy and mechanistic studies

(2013) Liqing Zheng et al.   LASERS IN MEDICAL SCIENCE

Autophagy: shaping the tumor microenvironment and therapeutic response

(2013) Hannelore Maes et al.   TRENDS IN MOLECULAR MEDICINE

Autophagy-dependent suppression of cancer immunogenicity and effector mechanisms of innate and adaptive immunity

(2013) Abhishek D Garg et al.   OncoImmunology

ATG7 deficiency suppresses apoptosis and cell death induced by lysosomal photodamage

(2012) David H. Kessel et al.   Autophagy

Macrophages in Tumor Microenvironments and the Progression of Tumors

(2012) Ning-Bo Hao et al.   Clinical & Developmental Immunology

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

(2012) Abhishek D Garg et al.   EMBO JOURNAL

Next generation sequencing for TCR repertoire profiling: Platform-specific features and correction algorithms

(2012) Dmitry A. Bolotin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The effect of photodynamic therapy on tumor cell expression of major histocompatibility complex (MHC) class I and MHC class I-related molecules

(2012) Alan Belicha-Villanueva et al.   LASERS IN SURGERY AND MEDICINE

Lymphopenia combined with low TCR diversity (divpenia) predicts poor overall survival in metastatic breast cancer patients

(2012) Manuarii Manuel et al.   OncoImmunology

Autophagy Contributes to the Death/Survival Balance in Cancer PhotoDynamic Therapy

(2012) Valentina Inguscio et al.   Cells

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Apoptotic and autophagic responses to photodynamic therapy in 1c1c7 murine hepatoma cells

(2011) Michelle Andrzejak et al.   Autophagy

Photodynamic therapy of cancer: An update

(2011) Patrizia Agostinis et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin

(2011) Abhishek D. Garg et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Involvement of damage-associated molecular patterns in tumor response to photodynamic therapy: surface expression of calreticulin and high-mobility group box-1 release

(2011) Mladen Korbelik et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Exhaustive T-cell repertoire sequencing of human peripheral blood samples reveals signatures of antigen selection and a directly measured repertoire size of at least 1 million clonotypes

(2011) R. L. Warren et al.   GENOME RESEARCH

Prognostic significance of tumor-infiltrating T cells in ovarian cancer: A meta-analysis

(2011) Wei-Ting Hwang et al.   GYNECOLOGIC ONCOLOGY

Induction of NKG2D Ligands and Increased Sensitivity of Tumor Cells to NK Cell-mediated Cytotoxicity by Hematoporphyrin-based Photodynamic Therapy

(2011) Min-Ju Park et al.   IMMUNOLOGICAL INVESTIGATIONS

DAMPs and PDT-mediated photo-oxidative stress: exploring the unknown

(2011) Abhishek D. Garg et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Cell Death Pathways in Photodynamic Therapy of Cancer

(2011) Pawel Mroz et al.   Cancers

Photodynamic therapy: illuminating the road from cell death towards anti-tumour immunity

(2010) Abhishek D. Garg et al.   APOPTOSIS

Assessing autophagy in the context of photodynamic therapy

(2010) John J. Reiners et al.   Autophagy

Synergistic Enhancement of Carboplatin Efficacy with Photodynamic Therapy in a Three-Dimensional Model for Micrometastatic Ovarian Cancer

(2010) I. Rizvi et al.   CANCER RESEARCH

Activatable Photosensitizers for Imaging and Therapy

(2010) Jonathan F. Lovell et al.   CHEMICAL REVIEWS

Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization

(2010) Jonathan P. Celli et al.   CHEMICAL REVIEWS

Stimulation of anti-tumor immunity by photodynamic therapy

(2010) Pawel Mroz et al.   Expert Review of Clinical Immunology

Photochemical internalization provides time- and space-controlled endolysosomal escape of therapeutic molecules

(2010) Pål Kristian Selbo et al.   JOURNAL OF CONTROLLED RELEASE

Human serum albumin as key mediator of the differential accumulation of hypericin in normal urothelial cell spheroids versusurothelial cell carcinoma spheroids

(2010) Mieke Roelants et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Permanent Occlusion of Feeding Arteries and Draining Veins in Solid Mouse Tumors by Vascular Targeted Photodynamic Therapy (VTP) with Tookad

(2010) Noa Madar-Balakirski et al.   PLoS One

Photodynamic Therapy of Tumors Can Lead to Development of Systemic Antigen-Specific Immune Response

(2010) Pawel Mroz et al.   PLoS One

Expression of calreticulin is associated with infiltration of T-cells in stage IIIB colon cancer

(2010) Rui-Qing Peng   WORLD JOURNAL OF GASTROENTEROLOGY

The effect of photodynamic therapy on tumor angiogenesis

(2009) Ramaswamy Bhuvaneswari et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Enhanced Systemic Immune Reactivity to a Basal Cell Carcinoma Associated Antigen Following Photodynamic Therapy

(2009) E. Kabingu et al.   CLINICAL CANCER RESEARCH

Biomolecular Network Reconstruction Identifies T-Cell Homing Factors Associated With Survival in Colorectal Cancer

(2009) Bernhard Mlecnik et al.   GASTROENTEROLOGY

Enhancement of anti-tumor immunity by photodynamic therapy

(2009) Sandra O. Gollnick et al.   IMMUNOLOGIC RESEARCH

Dual Control of Antitumor CD8 T Cells through the Programmed Death-1/Programmed Death-Ligand 1 Pathway and Immunosuppressive CD4 T Cells: Regulation and Counterregulation

(2009) A. J. Currie et al.   JOURNAL OF IMMUNOLOGY

Autophagy and Its Role in MHC-Mediated Antigen Presentation

(2009) V. L. Crotzer et al.   JOURNAL OF IMMUNOLOGY

Alarmins link neutrophils and dendritic cells

(2009) De Yang et al.   TRENDS IN IMMUNOLOGY

Efficient Cross-presentation Depends on Autophagy in Tumor Cells

(2008) Y. Li et al.   CANCER RESEARCH

Combination of Photodynamic Therapy with Anti-Cancer Agents

(2008) M.-F. Zuluaga et al.   CURRENT MEDICINAL CHEMISTRY

Differential Accumulation of Hypericin in Spheroids Composed of T-24 Transitional Cell Carcinoma Cells Expressing Different Levels of E-Cadherin

(2008) Ann Huygens et al.   JOURNAL OF UROLOGY

Generation of effective vaccines against liver cancer by using photodynamic therapy

(2008) Hongyu Zhang et al.   LASERS IN MEDICAL SCIENCE