Immunomodulation of the Tumor Microenvironment: Turn Foe Into Friend

Small molecule immuno-oncology therapeutic agents

(2018) Peter L. Toogood   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Oncolytic Viruses as Antigen-Agnostic Cancer Vaccines

(2018) Stephen J. Russell et al.   CANCER CELL

Antitumor in situ vaccination effect of TNFα and IL-12 plasmid DNA electrotransfer in a murine melanoma model

(2018) Urska Kamensek et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Oncogene-induced senescence and tumour control in complex biological systems

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Electrochemotherapy as a New Modality in Interventional Oncology: A Review

(2018) Ute Probst et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Exosomes Shuttle TREX1-Sensitive IFN-Stimulatory dsDNA from Irradiated Cancer Cells to DCs

(2018) Julie M. Diamond et al.   Cancer Immunology Research

Oncolytic Viral Therapy and the Immune System: A Double-Edged Sword Against Cancer

(2018) Giulia Marelli et al.   Frontiers in Immunology

TNFa and IL-2 armed adenoviruses enable complete responses by anti-PD-1 checkpoint blockade

(2018) V. Cervera-Carrascon et al.   OncoImmunology

Lighting a Fire in the Tumor Microenvironment Using Oncolytic Immunotherapy

(2018) Carole Achard et al.   EBioMedicine

Designing and building oncolytic viruses

(2017) Justin Maroun et al.   Future Virology

Abscopal, immunological effects of radiotherapy: Narrowing the gap between clinical and preclinical experiences

(2017) Nikko Brix et al.   IMMUNOLOGICAL REVIEWS

European Association for Neuro-Oncology (EANO) guideline on the diagnosis and treatment of adult astrocytic and oligodendroglial gliomas

(2017) Michael Weller et al.   LANCET ONCOLOGY

Oncolytic Virotherapy: A Contest between Apples and Oranges

(2017) Stephen J. Russell et al.   MOLECULAR THERAPY

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

(2017) Claire Vanpouille-Box et al.   Nature Communications

Safety and feasibility of electrochemotherapy in patients with unresectable colorectal liver metastases: A pilot study

(2017) Laura Coletti et al.   International Journal of Surgery

Oncolytic Immunotherapy: Conceptual Evolution, Current Strategies, and Future Perspectives

(2017) Zong Sheng Guo et al.   Frontiers in Immunology

Barriers to Radiation-Induced In Situ Tumor Vaccination

(2017) Erik Wennerberg et al.   Frontiers in Immunology

Oncolytic viruses sensitize human tumor cells for NY-ESO-1 tumor antigen recognition by CD4+ effector T cells.

(2017) Tiphaine Delaunay et al.   OncoImmunology

Trial watch: Immune checkpoint blockers for cancer therapy

(2017) Claire Vanpouille-Box et al.   OncoImmunology

Oncolytic Adenoviruses Armed with Tumor Necrosis Factor Alpha and Interleukin-2 Enable Successful Adoptive Cell Therapy

(2017) Riikka Havunen et al.   Molecular Therapy-Oncolytics

Targeting the Heterogeneity of Cancer with Individualized Neoepitope Vaccines

(2016) O. Tu reci et al.   CLINICAL CANCER RESEARCH

Therapeutic hyperthermia: The old, the new, and the upcoming

(2016) Matthew Mallory et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Immunocytokines for cancer treatment: past, present and future

(2016) Dario Neri et al.   CURRENT OPINION IN IMMUNOLOGY

Rationale for anti-OX40 cancer immunotherapy

(2016) Sandrine Aspeslagh et al.   EUROPEAN JOURNAL OF CANCER

Does Heavy Ion Therapy Work Through the Immune System?

(2016) Marco Durante et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Tumor Cells Surviving Exposure to Proton or Photon Radiation Share a Common Immunogenic Modulation Signature, Rendering Them More Sensitive to T Cell–Mediated Killing

(2016) Sofia R. Gameiro et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Talimogene Laherparepvec in Combination With Ipilimumab in Previously Untreated, Unresectable Stage IIIB-IV Melanoma

(2016) Igor Puzanov et al.   JOURNAL OF CLINICAL ONCOLOGY

Nanotechnology in hyperthermia cancer therapy: From fundamental principles to advanced applications

(2016) Jaber Beik et al.   JOURNAL OF CONTROLLED RELEASE

Intratumoral Delivery of Immunotherapy—Act Locally, Think Globally

(2016) M. Angela Aznar et al.   JOURNAL OF IMMUNOLOGY

IMST-26. TUMOR TREATING FIELDS EXPOSURE OF TUMOR CELLS INDUCE ACTIVATION PHENOTYPE IN IMMUNE CELLS

(2016) Talia Holtzman   NEURO-ONCOLOGY

Tumor treating fields: a novel treatment modality and its use in brain tumors

(2016) Andreas F. Hottinger et al.   NEURO-ONCOLOGY

TTFields: where does all the skepticism come from?

(2016) Wolfgang Wick   NEURO-ONCOLOGY

Electrochemotherapy in the Treatment of Bone Metastases: A Phase II Trial

(2016) Giuseppe Bianchi et al.   WORLD JOURNAL OF SURGERY

Chemoradiation Increases PD-L1 Expression in Certain Melanoma and Glioblastoma Cells

(2016) Anja Derer et al.   Frontiers in Immunology

The effect of ionizing radiation on regulatory T cells in health and disease

(2015) Eszter Persa et al.   CANCER LETTERS

TGFβ Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity

(2015) Claire Vanpouille-Box et al.   CANCER RESEARCH

Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors

(2015) J. R. Baird et al.   CANCER RESEARCH

Ablative Tumor Radiation Can Change the Tumor Immune Cell Microenvironment to Induce Durable Complete Remissions

(2015) A. Filatenkov et al.   CLINICAL CANCER RESEARCH

Landscape of Tumor Antigens in T Cell Immunotherapy

(2015) S. Ilyas et al.   JOURNAL OF IMMUNOLOGY

Long-term remission of primary cutaneous neutrophil-rich CD30+ anaplastic large cell lymphoma treated with topical imiquimod. A case report

(2015) D. Calista et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Intratumoral electroporation of plasmid interleukin-12: efficacy and biomarker analyses from a phase 2 study in melanoma (OMS-I100)

(2015) Adil Daud et al.   Journal of Translational Medicine

Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial

(2015) Encouse B Golden et al.   LANCET ONCOLOGY

In situ vaccination: Cancer immunotherapy both personalized and off-the-shelf

(2015) Linda Hammerich et al.   Molecular Oncology

Phase 1b Trial of Biweekly Intravenous Pexa-Vec (JX-594), an Oncolytic and Immunotherapeutic Vaccinia Virus in Colorectal Cancer

(2015) Se Hoon Park et al.   MOLECULAR THERAPY

Phase 1 Study of Intratumoral Pexa-Vec (JX-594), an Oncolytic and Immunotherapeutic Vaccinia Virus, in Pediatric Cancer Patients

(2015) Timothy P Cripe et al.   MOLECULAR THERAPY

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

(2015) Christina Twyman-Saint Victor et al.   NATURE

In situ vaccination with cowpea mosaic virus nanoparticles suppresses metastatic cancer

(2015) P. H. Lizotte et al.   Nature Nanotechnology

Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1

(2015) E. Vacchelli et al.   SCIENCE

Current Clinical Trials Testing Combinations of Immunotherapy and Radiation

(2015) Marka Crittenden et al.   SEMINARS IN RADIATION ONCOLOGY

First Oncolytic Viral Therapy for Melanoma

(2015)   Cancer Discovery

Electrochemotherapy in locally advanced pancreatic cancer: Preliminary results

(2015) V. Granata et al.   International Journal of Surgery

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

(2015) Leticia Corrales et al.   Cell Reports

Intratumoral Delivery of TriMix mRNA Results in T-cell Activation by Cross-Presenting Dendritic Cells

(2015) S. Van Lint et al.   Cancer Immunology Research

Assessment of current virotherapeutic application schemes: “hit hard and early” versus “killing softly”?

(2015) Benjamin Ruf et al.   Molecular Therapy-Oncolytics

Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing

(2015) Sofia R. Gameiro et al.   Oncotarget

Combination of Oncolytic Herpes Simplex Viruses Armed with Angiostatin and IL-12 Enhances Antitumor Efficacy in Human Glioblastoma Models

(2015) Wei Zhang et al.   NEOPLASIA

Tumor-specific oncolytic adenoviruses expressing granulocyte macrophage colony-stimulating factor or anti-CTLA4 antibody for the treatment of cancers

(2014) T Du et al.   CANCER GENE THERAPY

Acquired Resistance to Fractionated Radiotherapy Can Be Overcome by Concurrent PD-L1 Blockade

(2014) S. J. Dovedi et al.   CANCER RESEARCH

The Human Agonistic CD40 Antibody ADC-1013 Eradicates Bladder Tumors and Generates T-cell-Dependent Tumor Immunity

(2014) S. M. Mangsbo et al.   CLINICAL CANCER RESEARCH

Electrochemotherapy in Breast Cancer: A Review of References

(2014) G. Schmidt et al.   GEBURTSHILFE UND FRAUENHEILKUNDE

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

Irradiation and anti–PD-L1 treatment synergistically promote antitumor immunity in mice

(2014) Liufu Deng et al.   JOURNAL OF CLINICAL INVESTIGATION

Imiquimod in the Treatment of Breast Cancer Skin Metastasis

(2014) Lisa Henriques et al.   JOURNAL OF CLINICAL ONCOLOGY

Radiation-Induced CXCL16 Release by Breast Cancer Cells Attracts Effector T Cells

(2014) S. Matsumura et al.   JOURNAL OF IMMUNOLOGY

Radiation-Induced IFN-  Production within the Tumor Microenvironment Influences Antitumor Immunity

(2014) A. A. Lugade et al.   JOURNAL OF IMMUNOLOGY

Effective Innate and Adaptive Antimelanoma Immunity through Localized TLR7/8 Activation

(2014) Manisha Singh et al.   JOURNAL OF IMMUNOLOGY

CTLA-4 and PD-L1 Checkpoint Blockade Enhances Oncolytic Measles Virus Therapy

(2014) Christine E Engeland et al.   MOLECULAR THERAPY

Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

(2014) Antonella Sistigu et al.   NATURE MEDICINE

Localized Oncolytic Virotherapy Overcomes Systemic Tumor Resistance to Immune Checkpoint Blockade Immunotherapy

(2014) D. Zamarin et al.   Science Translational Medicine

Stereotactic Radiation Therapy Augments Antigen-Specific PD-1-Mediated Antitumor Immune Responses via Cross-Presentation of Tumor Antigen

(2014) A. B. Sharabi et al.   Cancer Immunology Research

Therapeutic In Situ Autovaccination against Solid Cancers with Intratumoral Poly-ICLC: Case Report, Hypothesis, and Clinical Trial

(2014) A. M. Salazar et al.   Cancer Immunology Research

Is tumor (R)ejection by the immune system the “5th R” of radiobiology?

(2014) Encouse Golden et al.   OncoImmunology

Invariant natural killer T cells regulate anti-tumor immunity by controlling the population of dendritic cells in tumor and draining lymph nodes

(2014) Karsten A Pilones et al.   Journal for ImmunoTherapy of Cancer

Converting tumors into vaccine manufacturing factories: DC recruitment, activation and clinical responses with a flt3L-primed in situ vaccine for low-grade lymphoma [nct01976585]

(2014) Nina Bhardwaj et al.   Journal for ImmunoTherapy of Cancer

OX40 Is a Potent Immune-Stimulating Target in Late-Stage Cancer Patients

(2013) B. D. Curti et al.   CANCER RESEARCH

Controlled Local Delivery of CTLA-4 Blocking Antibody Induces CD8+ T-Cell-Dependent Tumor Eradication and Decreases Risk of Toxic Side Effects

(2013) M. F. Fransen et al.   CLINICAL CANCER RESEARCH

Oncolytic vaccines

(2013) Noura B Elsedawy et al.   Expert Review of Vaccines

Antigen Availability Determines CD8+ T Cell-Dendritic Cell Interaction Kinetics and Memory Fate Decisions

(2013) Sarah E. Henrickson et al.   IMMUNITY

RAGE and TLRs: Relatives, friends or neighbours?

(2013) Zaridatul Aini Ibrahim et al.   MOLECULAR IMMUNOLOGY

Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer

(2013) Jeong Heo et al.   NATURE MEDICINE

Charged particle therapy—optimization, challenges and future directions

(2013) Jay S. Loeffler et al.   Nature Reviews Clinical Oncology

The Peripheral Myeloid Expansion Driven by Murine Cancer Progression Is Reversed by Radiation Therapy of the Tumor

(2013) Marka R. Crittenden et al.   PLoS One

Multifaceted oncolytic virus therapy for glioblastoma in an immunocompetent cancer stem cell model

(2013) T. A. Cheema et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune Response Is an Important Aspect of the Antitumor Effect Produced by a CD40L-Encoding Oncolytic Adenovirus

(2012) I. Diaconu et al.   CANCER RESEARCH

Oncolytic Immunotherapy of Advanced Solid Tumors with a CD40L-Expressing Replicating Adenovirus: Assessment of Safety and Immunologic Responses in Patients

(2012) S. Pesonen et al.   CANCER RESEARCH

Exploiting the Mutanome for Tumor Vaccination

(2012) J. C. Castle et al.   CANCER RESEARCH

Topical TLR7 Agonist Imiquimod Can Induce Immune-Mediated Rejection of Skin Metastases in Patients with Breast Cancer

(2012) S. Adams et al.   CLINICAL CANCER RESEARCH

Synergy of Topical Toll-like Receptor 7 Agonist with Radiation and Low-Dose Cyclophosphamide in a Mouse Model of Cutaneous Breast Cancer

(2012) M. Z. Dewan et al.   CLINICAL CANCER RESEARCH

Particle-mediated delivery of cytokines for immunotherapy

(2012) David A Christian et al.   Immunotherapy

The effect of ionizing radiation on the homeostasis and functional integrity of murine splenic regulatory T cells

(2012) Andrea Balogh et al.   INFLAMMATION RESEARCH

An Oncolytic Adenovirus Enhanced for Toll-like Receptor 9 Stimulation Increases Antitumor Immune Responses and Tumor Clearance

(2012) Vincenzo Cerullo et al.   MOLECULAR THERAPY

Image-guided radiotherapy: from current concept to future perspectives

(2012) David A. Jaffray   Nature Reviews Clinical Oncology

Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma

(2012) Michael A. Postow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expression of NF-κB p50 in Tumor Stroma Limits the Control of Tumors by Radiation Therapy

(2012) Marka R. Crittenden et al.   PLoS One

An Immunosurveillance Mechanism Controls Cancer Cell Ploidy

(2012) L. Senovilla et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

In the field: exploiting the untapped potential of immunogenic modulation by radiation in combination with immunotherapy for the treatment of cancer

(2012) Anna R. Kwilas   Frontiers in Oncology

Photodynamic therapy of cancer: An update

(2011) Patrizia Agostinis et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Local Activation of CD8 T Cells and Systemic Tumor Eradication without Toxicity via Slow Release and Local Delivery of Agonistic CD40 Antibody

(2011) M. F. Fransen et al.   CLINICAL CANCER RESEARCH

Toll-like receptors

(2011) Eva Marie Y. Moresco et al.   CURRENT BIOLOGY

Targeted cancer immunotherapy with oncolytic adenovirus coding for a fully human monoclonal antibody specific for CTLA-4

(2011) J D Dias et al.   GENE THERAPY

Treatment of Locally Recurrent Mucosal Melanoma With Topical Imiquimod

(2011) Elizabeth C. Smyth et al.   JOURNAL OF CLINICAL ONCOLOGY

Host type I IFN signals are required for antitumor CD8+T cell responses through CD8α+dendritic cells

(2011) Mercedes B. Fuertes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Oncolytic Poxvirus JX-594 Selectively Replicates in and Destroys Cancer Cells Driven by Genetic Pathways Commonly Activated in Cancers

(2011) Kelley A Parato et al.   MOLECULAR THERAPY

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

High response rate after intratumoral treatment with interleukin-2

(2010) Benjamin Weide et al.   CANCER

Blockade of Tumor Necrosis Factor   Signaling in Tumor-Associated Macrophages as a Radiosensitizing Strategy

(2010) Y. Meng et al.   CANCER RESEARCH

Radiation Enhances Regulatory T Cell Representation

(2010) Evelyn L. Kachikwu et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

In Situ Vaccination With a TLR9 Agonist Induces Systemic Lymphoma Regression: A Phase I/II Study

(2010) Joshua D. Brody et al.   JOURNAL OF CLINICAL ONCOLOGY

T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis

(2010) Maria R Parkhurst et al.   MOLECULAR THERAPY

Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

(2010) Faraaz B. Chekeni et al.   NATURE

Heavy-ion tumor therapy: Physical and radiobiological benefits

(2010) Dieter Schardt et al.   REVIEWS OF MODERN PHYSICS

Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti-CTLA-4 Antibody

(2009) M. Z. Dewan et al.   CLINICAL CANCER RESEARCH

Phase-I clinical trial of IL-12 plasmid/lipopolymer complexes for the treatment of recurrent ovarian cancer

(2009) K Anwer et al.   GENE THERAPY

Molecular mechanism and function of CD40/CD40L engagement in the immune system

(2009) Raul Elgueta et al.   IMMUNOLOGICAL REVIEWS

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Charged particles in radiation oncology

(2009) Marco Durante et al.   Nature Reviews Clinical Oncology

Electrochemotherapy of Tumours

(2009) Gregor Sersa et al.   Jove-Journal of Visualized Experiments

T-cell modulation combined with intratumoral CpG cures lymphoma in a mouse model without the need for chemotherapy

(2008) R. Houot et al.   BLOOD

Innate immunity to virus infection

(2008) Osamu Takeuchi et al.   IMMUNOLOGICAL REVIEWS

Arming parvoviruses with CpG motifs to improve their oncosuppressive capacity

(2008) Zahari Raykov et al.   INTERNATIONAL JOURNAL OF CANCER

Electrochemotherapy in treatment of tumours

(2007) G. Sersa et al.   EJSO