Cell-Penetrating Peptides and Transportan

Developing DMD therapeutics: a review of the effectiveness of small molecules, stop-codon readthrough, dystrophin gene replacement, and exon-skipping therapies

(2021) Omar Sheikh et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Improved Cellular Delivery of Antisense Oligonucleotide for miRNA-21 Imaging In Vivo Using Cell-Penetrating Peptide-Based Nanoprobes

(2021) Guangjie Yang et al.   MOLECULAR PHARMACEUTICS

Advances in peptide-mediated cytosolic delivery of proteins

(2021) Macarena Sánchez-Navarro   ADVANCED DRUG DELIVERY REVIEWS

Proteogenomic interrogation of cancer cell lines: an overview of the field

(2021) Olson Tsang et al.   Expert Review of Proteomics

The role of peptide-based therapeutics in oncotherapy

(2021) Selin Seda Timur et al.   JOURNAL OF DRUG TARGETING

Transportan Peptide Stimulates the Nanomaterial Internalization into Mammalian Cells in the Bystander Manner through Macropinocytosis

(2021) Yue-Xuan Li et al.   Pharmaceutics

Protein Expression Correlates Linearly with mRNA Dose over Up to Five Orders of Magnitude In Vitro and In Vivo

(2021) Alexander H. van Asbeck et al.   Biomedicines

Drug Conjugation Induced Modulation of Structural and Membrane Interaction Features of Cationic Cell-Permeable Peptides

(2020) Edit Pári et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Location of Peptide-Induced Submicron Discontinuities in the Membranes of Vesicles Using ImageJ

(2020) Mohammad Abu Sayem Karal et al.   JOURNAL OF FLUORESCENCE

Conjugates of Ciprofloxacin and Levofloxacin with Cell-Penetrating Peptide Exhibit Antifungal Activity and Mammalian Cytotoxicity

(2020) Natalia Ptaszyńska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Carbonized chitosan encapsulated hierarchical porous zeolitic imidazolate frameworks nanoparticles for gene delivery

(2020) Hani Nasser Abdelhamid et al.   MICROPOROUS AND MESOPOROUS MATERIALS

Gene delivery using cell penetrating peptides-zeolitic imidazolate frameworks

(2020) Hani Nasser Abdelhamid et al.   MICROPOROUS AND MESOPOROUS MATERIALS

Nanoparticle delivery of immunostimulatory oligonucleotides enhances response to checkpoint inhibitor therapeutics

(2020) Colin G. Buss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Status update in the use of cell-penetrating peptides for the delivery of macromolecular therapeutics

(2020) Kaido Kurrikoff et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

NickFect type of cell-penetrating peptides present enhanced efficiency for microRNA-146a delivery into dendritic cells and during skin inflammation

(2020) Gemma Carreras-Badosa et al.   BIOMATERIALS

Transcriptional Profiling Reveals Ribosome Biogenesis, Microtubule Dynamics and Expression of Specific lncRNAs to be Part of a Common Response to Cell-Penetrating Peptides

(2020) Tomas Venit et al.   Biomolecules

Peptide-mediated delivery of therapeutic mRNA in ovarian cancer

(2019) Dirk van den Brand et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Transportan-derived cell-penetrating peptide delivers siRNA to inhibit replication of influenza virus in vivo

(2019) Cuiling Zhang et al.   Drug Design Development and Therapy

Transportan 10 improves the pharmacokinetics and pharmacodynamics of vancomycin

(2019) Jarosław Ruczyński et al.   Scientific Reports

The nuclear concentration required for antisense oligonucleotide activity in myotonic dystrophy cells

(2019) M. Leontien van der Bent et al.   FASEB JOURNAL

Cell-penetrating peptide sequence and modification dependent uptake and subcellular distribution of green florescent protein in different cell lines

(2019) Sanjay G. Patel et al.   Scientific Reports

Recent CPP-based applications in medicine

(2019) Kaido Kurrikoff et al.   Expert Opinion on Drug Delivery

Role of Membrane Potential on Entry of Cell-Penetrating Peptide Transportan 10 into Single Vesicles

(2019) Md. Mizanur Rahman Moghal et al.   BIOPHYSICAL JOURNAL

Effective lung-targeted RNAi in mice with peptide-based delivery of nucleic acid

(2019) Kaido Kurrikoff et al.   Scientific Reports

Simultaneous membrane interaction of amphipathic peptide monomers, self-aggregates and cargo complexes detected by fluorescence correlation spectroscopy

(2018) Luís Vasconcelos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Continuous detection of entry of cell-penetrating peptide transportan 10 into single vesicles

(2018) Md. Mizanur Rahman Moghal et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Label-Free Confocal Raman Mapping of Transportan in Melanoma Cells

(2018) Patrick J. Cosme et al.   MOLECULAR PHARMACEUTICS

A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors

(2018) Mariano J. Alvarez et al.   NATURE GENETICS

Cell-penetrating peptides for siRNA delivery to glioblastomas

(2018) Artita Srimanee et al.   PEPTIDES

Formulation of Stable and Homogeneous Cell-Penetrating Peptide NF55 Nanoparticles for Efficient Gene Delivery In Vivo

(2018) Krista Freimann et al.   Molecular Therapy-Nucleic Acids

Cell-penetrating peptides recruit type A scavenger receptors to the plasma membrane for cellular delivery of nucleic acids

(2017) Carmen Juks et al.   FASEB JOURNAL

Perfluoroarene–Based Peptide Macrocycles to Enhance Penetration Across the Blood–Brain Barrier

(2017) Colin M. Fadzen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effects of Mechanical Properties of Lipid Bilayers on the Entry of Cell-Penetrating Peptides into Single Vesicles

(2017) Md. Zahidul Islam et al.   LANGMUIR

Magnetic Nanoparticle Assisted Self-assembly of Cell Penetrating Peptides-Oligonucleotides Complexes for Gene Delivery

(2017) Moataz Dowaidar et al.   Scientific Reports

Role of autophagy in cell-penetrating peptide transfection model

(2017) Moataz Dowaidar et al.   Scientific Reports

Glycosaminoglycans are required for translocation of amphipathic cell-penetrating peptides across membranes

(2016) Janely Pae et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Charge Distribution Fine-Tunes the Translocation of α -Helical Amphipathic Peptides across Membranes

(2016) Francis D.O. Ablan et al.   BIOPHYSICAL JOURNAL

Role of scavenger receptors in peptide-based delivery of plasmid DNA across a blood–brain barrier model

(2016) Artita Srimanee et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

pH-responsive PepFect cell-penetrating peptides

(2016) Jakob Regberg et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

In vivo DNA delivery with NickFect peptide vectors

(2016) Kinam Park   JOURNAL OF CONTROLLED RELEASE

Optimization of in vivo DNA delivery with NickFect peptide vectors

(2016) Krista Freimann et al.   JOURNAL OF CONTROLLED RELEASE

Transportan 10 improves the anticancer activity of cisplatin

(2016) Rusiecka Izabela et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Delivery of therapeutic oligonucleotides with cell penetrating peptides

(2015) Prisca Boisguérin et al.   ADVANCED DRUG DELIVERY REVIEWS

Cationic PTD/CPP-mediated macromolecular delivery: charging into the cell

(2015) Peter Lönn et al.   Expert Opinion on Drug Delivery

Recentin vivoadvances in cell-penetrating peptide-assisted drug delivery

(2015) Kaido Kurrikoff et al.   Expert Opinion on Drug Delivery

Protein and siRNA delivery by transportan and transportan 10 into colorectal cancer cell lines

(2015) Piotr M. Wierzbicki et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

PEG shielded MMP sensitive CPPs for efficient and tumor specific gene delivery in vivo

(2015) Kadi-Liis Veiman et al.   JOURNAL OF CONTROLLED RELEASE

Methods to follow intracellular trafficking of cell-penetrating peptides

(2015) Ly Pärnaste et al.   JOURNAL OF DRUG TARGETING

Antimicrobial activities and action mechanism studies of transportan 10 and its analogues against multidrug-resistant bacteria

(2015) Junqiu Xie et al.   JOURNAL OF PEPTIDE SCIENCE

Cell-Penetrating Peptides Selectively Cross the Blood-Brain Barrier In Vivo

(2015) Sofie Stalmans et al.   PLoS One

Entry of Cell-Penetrating Peptide Transportan 10 into a Single Vesicle by Translocating Across Lipid Membrane and Its Induced Pores

(2014) Md. Zahidul Islam et al.   BIOCHEMISTRY

Effects of cargo molecules on membrane perturbation caused by transportan10 based cell-penetrating peptides

(2014) Luís Vasconcelos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

LXXLL Peptide Converts Transportan 10 to a Potent Inducer of Apoptosis in Breast Cancer Cells

(2014) Kairit Tints et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rational design of a series of novel amphipathic cell-penetrating peptides

(2014) Jakob Regberg et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Distal phenylalanine modification for enhancing cellular delivery of fluorophores, proteins and quantum dots by cell penetrating peptides

(2014) E.J. Sayers et al.   JOURNAL OF CONTROLLED RELEASE

A survey on “Trojan Horse” peptides: Opportunities, issues and controlled entry to “Troy”

(2014) Nian-Qiu Shi et al.   JOURNAL OF CONTROLLED RELEASE

Translocation of cell-penetrating peptides across the plasma membrane is controlled by cholesterol and microenvironment created by membranous proteins

(2014) Janely Pae et al.   JOURNAL OF CONTROLLED RELEASE

Structural and Thermodynamic Insight into Spontaneous Membrane-Translocating Peptides Across Model PC/PG Lipid Bilayers

(2014) Yuan Hu et al.   JOURNAL OF MEMBRANE BIOLOGY

A Myristoylated Cell-Penetrating Peptide Bearing a Transferrin Receptor-Targeting Sequence for Neuro-Targeted siRNA Delivery

(2014) Pilju Youn et al.   MOLECULAR PHARMACEUTICS

Transcriptome in vivo analysis (TIVA) of spatially defined single cells in live tissue

(2014) Ditte Lovatt et al.   NATURE METHODS

Structure Analysis and Conformational Transitions of the Cell Penetrating Peptide Transportan 10 in the Membrane-Bound State

(2014) Susanne Fanghänel et al.   PLoS One

Insights into cell entry and intracellular trafficking of peptide and protein drugs provided by electron microscopy

(2013) Helerin Margus et al.   ADVANCED DRUG DELIVERY REVIEWS

Identification of Cell-Penetrating Peptides That Are Bactericidal to Neisseria meningitidis and Prevent Inflammatory Responses upon Infection

(2013) Olaspers Sara Eriksson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

New generation of efficient peptide-based vectors, NickFects, for the delivery of nucleic acids

(2013) Piret Arukuusk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A pH-responsive α-helical cell penetrating peptide-mediated liposomal delivery system

(2013) Qianyu Zhang et al.   BIOMATERIALS

Translocation of cell penetrating peptides onChlamydomonas reinhardtii

(2013) Arumuganainar Suresh et al.   BIOTECHNOLOGY AND BIOENGINEERING

Bioportides: Bioactive cell-penetrating peptides that modulate cellular dynamics

(2013) Monika Lukanowska et al.   Biotechnology Journal

Cell-penetrating peptide secures an efficient endosomal escape of an intact cargo upon a brief photo-induction

(2013) Helin Räägel et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Everything You Always Wanted to Know About CADY-Mediated siRNA Delivery* (* But Afraid to Ask)

(2013) Karidia Konate et al.   CURRENT PHARMACEUTICAL DESIGN

Cell penetrating peptides fail to induce an innate immune response in epithelial cells in vitro: Implications for continued therapeutic use

(2013) Edward Carter et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Influence of stearyl and trifluoromethylquinoline modifications of the cell penetrating peptide TP10 on its interaction with a lipid membrane

(2012) Maja Anko et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Molecular Dynamic Studies of Transportan Interacting with a DPPC Lipid Bilayer

(2012) Mohsen Pourmousa et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Cell-Penetrating Peptides, PepFects, Show No Evidence of Toxicity and ImmunogenicityIn VitroandIn Vivo

(2011) Julia Suhorutsenko et al.   BIOCONJUGATE CHEMISTRY

Design of Acid-Activated Cell Penetrating Peptide for Delivery of Active Molecules into Cancer Cells

(2011) Wei Zhang et al.   BIOCONJUGATE CHEMISTRY

Protein transduction domain delivery of therapeutic macromolecules

(2011) Arjen van den Berg et al.   CURRENT OPINION IN BIOTECHNOLOGY

Antimicrobial and cell-penetrating peptides induce lipid vesicle fusion by folding and aggregation

(2011) Parvesh Wadhwani et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

NickFects, Phosphorylated Derivatives of Transportan 10 for Cellular Delivery of Oligonucleotides

(2011) Nikita Oskolkov et al.   International Journal of Peptide Research and Therapeutics

Distinct transduction modes of arginine-rich cell-penetrating peptides for cargo delivery into tumor cells

(2011) Dong-Xu Ma et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Penetration without cells: Membrane translocation of cell-penetrating peptides in the model giant plasma membrane vesicles

(2011) Pille Säälik et al.   JOURNAL OF CONTROLLED RELEASE

A Peptide-based Vector for Efficient Gene Transfer In Vitro and In Vivo

(2011) Taavi Lehto et al.   MOLECULAR THERAPY

Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo

(2011) Samir EL Andaloussi et al.   NUCLEIC ACIDS RESEARCH

PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation

(2011) Kariem Ezzat et al.   NUCLEIC ACIDS RESEARCH

Cellular uptake of transportan 10 and its analogs in live cells: Selectivity and structure–activity relationship studies

(2011) Jingjing Song et al.   PEPTIDES

Stable isotope-resolved metabolomics and applications for drug development

(2011) Teresa W.-M. Fan et al.   PHARMACOLOGY & THERAPEUTICS

Insight into the Cellular Uptake Mechanism of a Secondary Amphipathic Cell-Penetrating Peptide for siRNA Delivery

(2010) Karidia Konate et al.   BIOCHEMISTRY

A Thermodynamic Approach to the Mechanism of Cell-Penetrating Peptides in Model Membranes

(2010) Alesia N. McKeown et al.   BIOCHEMISTRY

Structural polymorphism of non-covalent peptide-based delivery systems: Highway to cellular uptake

(2010) Sébastien Deshayes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Knockdown of L Calcium Channel Subtypes: Differential Effects in Neuropathic Pain

(2010) P. Fossat et al.   JOURNAL OF NEUROSCIENCE

Molecular Dynamics Studies of Transportan 10 (Tp10) Interacting with a POPC Lipid Bilayer

(2010) Christina M. Dunkin et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The Pharmacokinetics of Cell-Penetrating Peptides

(2010) Dikran Sarko et al.   MOLECULAR PHARMACEUTICS

Wasp Mastoparans Follow the Same Mechanism as the Cell-Penetrating Peptide Transportan 10

(2009) Lindsay E. Yandek et al.   BIOCHEMISTRY

Elucidating cell-penetrating peptide mechanisms of action for membrane interaction, cellular uptake, and translocation utilizing the hydrophobic counter-anion pyrenebutyrate

(2009) Peter Guterstam et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Assessing the uptake kinetics and internalization mechanisms of cell-penetrating peptides using a quenched fluorescence assay

(2009) Imre Mäger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Protein Delivery with Transportans Is Mediated by Caveolae Rather Than Flotillin-Dependent Pathways

(2009) Pille Säälik et al.   BIOCONJUGATE CHEMISTRY

Intracellular delivery of siRNA by cell-penetrating peptides modified with cationic oligopeptides

(2009) Tsutomu Ishihara et al.   DRUG DELIVERY

CPP–protein constructs induce a population of non-acidic vesicles during trafficking through endo-lysosomal pathway

(2009) Helin Räägel et al.   JOURNAL OF CONTROLLED RELEASE

Delivery of nucleic acids with a stearylated (RxR)4 peptide using a non-covalent co-incubation strategy

(2009) Taavi Lehto et al.   JOURNAL OF CONTROLLED RELEASE

Analysis of in vitro toxicity of five cell-penetrating peptides by metabolic profiling

(2009) Kalle Kilk et al.   TOXICOLOGY

Small Changes in the Primary Structure of Transportan 10 Alter the Thermodynamics and Kinetics of its Interaction with Phospholipid Vesicles†

(2008) Lindsay E. Yandek et al.   BIOCHEMISTRY

Structural polymorphism of two CPP: An important parameter of activity

(2008) Sébastien Deshayes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Distinct Uptake Routes of Cell-Penetrating Peptide Conjugates

(2008) Per Lundin et al.   BIOCONJUGATE CHEMISTRY

Peptide-Based Nanoparticle for Ex Vivo and In Vivo Dug Delivery

(2008) Laurence Crombez et al.   CURRENT PHARMACEUTICAL DESIGN

Study of uptake of cell penetrating peptides and their cargoes in permeabilized wheat immature embryos

(2008) Archana Chugh et al.   FEBS Journal

A stearylated CPP for delivery of splice correcting oligonucleotides using a non-covalent co-incubation strategy

(2008) Maarja Mäe et al.   JOURNAL OF CONTROLLED RELEASE

Arginine-rich cell penetrating peptides: Design, structure–activity, and applications to alter pre-mRNA splicing by steric-block oligonucleotides

(2008) R. Abes et al.   JOURNAL OF PEPTIDE SCIENCE

Cholesterol prevents interaction of the cell-penetrating peptide transportan with model lipid membranes

(2008) Zoran Arsov et al.   JOURNAL OF PEPTIDE SCIENCE

A New Potent Secondary Amphipathic Cell–penetrating Peptide for siRNA Delivery Into Mammalian Cells

(2008) Laurence Crombez et al.   MOLECULAR THERAPY