Inflammation, Aging and Hematopoiesis: A Complex Relationship

Chaperone-mediated autophagy sustains haematopoietic stem-cell function

(2021) Shuxian Dong et al.   NATURE

Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production

(2021) Joshua T. Weinreb et al.   DEVELOPMENTAL CELL

TLR7/8 agonist treatment induces an increase in bone marrow resident dendritic cells and hematopoietic progenitor expansion and mobilization

(2021) Sidan Li et al.   EXPERIMENTAL HEMATOLOGY

Yin and Yang: The dual effects of interferons on hematopoiesis

(2021) Yasmin Demerdash et al.   EXPERIMENTAL HEMATOLOGY

Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling

(2021) Daniel Hormaechea-Agulla et al.   Cell Stem Cell

PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress

(2021) James S. Chavez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Kdm6a Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with p53 Dysfunction

(2020) Kohei Kobatake et al.   CLINICAL CANCER RESEARCH

Dynamic responses of the haematopoietic stem cell niche to diverse stresses

(2020) Antoniana Batsivari et al.   NATURE CELL BIOLOGY

Aging-induced IL27Ra Signaling Impairs Hematopoietic Stem Cells

(2020) Hanqing He et al.   BLOOD

Genetics of Progression from MDS to Secondary Leukemia

(2020) Andrew J. Menssen et al.   BLOOD

Clonal Hematopoiesis: Mechanisms Driving Dominance of Stem Cell Clones

(2020) Grant Challen et al.   BLOOD

Regulation of the Bone Marrow Niche by Inflammation

(2020) Ioannis Mitroulis et al.   Frontiers in Immunology

Macrophages Orchestrate Hematopoietic Programs and Regulate HSC Function During Inflammatory Stress

(2020) Allison N. Seyfried et al.   Frontiers in Immunology

Inflammation-driven activation of JAK/STAT signaling reversibly accelerates acute myeloid leukemia in vitro

(2020) Jan Habbel et al.   Blood Advances

Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production

(2020) Jenna M. Frame et al.   DEVELOPMENTAL CELL

Myelodysplastic Syndromes

(2020) Mario Cazzola   NEW ENGLAND JOURNAL OF MEDICINE

Immunodeficiency and bone marrow failure with mosaic and germline TLR8 gain-of-function

(2020) Jahnavi Aluri et al.   BLOOD

Interferon Gamma Mediates Hematopoietic Stem Cell Activation and Niche Relocalization through BST2

(2020) Marcus A. Florez et al.   Cell Reports

UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes

(2020) Yasuyuki Sera et al.   BLOOD

Causes and Mechanisms of Hematopoietic Stem Cell Aging

(2019) Jungwoon Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The central role of inflammatory signaling in the pathogenesis of myelodysplastic syndromes

(2019) David A. Sallman et al.   BLOOD

The bone marrow microenvironment at single-cell resolution

(2019) Anastasia N. Tikhonova et al.   NATURE

Losing Sense of Self and Surroundings: Hematopoietic Stem Cell Aging and Leukemic Transformation

(2019) Evgenia V. Verovskaya et al.   TRENDS IN MOLECULAR MEDICINE

Interleukin-33 regulates hematopoietic stem cell regeneration after radiation injury

(2019) Ping Huang et al.   Stem Cell Research & Therapy

Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging

(2019) Ya-Hsuan Ho et al.   Cell Stem Cell

TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration

(2019) Masayuki Yamashita et al.   Cell Stem Cell

New paradigms on hematopoietic stem cell differentiation

(2019) Hui Cheng et al.   Protein & Cell

Haematopoietic stem cells in perisinusoidal niches are protected from ageing

(2019) Mehmet Saçma et al.   NATURE CELL BIOLOGY

Clonal hematopoiesis in human aging and disease

(2019) Siddhartha Jaiswal et al.   SCIENCE

Understanding intrinsic hematopoietic stem cell aging

(2019) Eva Mejia-Ramirez et al.   HAEMATOLOGICA

Microenvironmental contributions to hematopoietic stem cell aging

(2019) Ya-Hsuan Ho et al.   HAEMATOLOGICA

Global Transcriptomic Profiling of the Bone Marrow Stromal Microenvironment during Postnatal Development, Aging, and Inflammation

(2019) Patrick M. Helbling et al.   Cell Reports

Inflammatory bone marrow microenvironment

(2019) Nils B. Leimkühler et al.   Hematology-American Society of Hematology Education Program

The hematopoietic stem cell niche: from embryo to adult

(2018) Xin Gao et al.   DEVELOPMENT

An Intrinsic Interferon Program Protects Stem Cells from Viral Infection

(2018) Simon Haas et al.   DEVELOPMENTAL CELL

An inflammatory environment containing TNFα favors Tet2 -mutant clonal hematopoiesis

(2018) Samuel O. Abegunde et al.   EXPERIMENTAL HEMATOLOGY

Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche

(2018) Maria Maryanovich et al.   NATURE MEDICINE

Hematopoietic Hierarchy – An Updated Roadmap

(2018) Yifan Zhang et al.   TRENDS IN CELL BIOLOGY

Type I IFNs drive hematopoietic stem and progenitor cell collapse via impaired proliferation and increased RIPK1-dependent cell death during shock-like ehrlichial infection

(2018) Julianne N. P. Smith et al.   PLoS Pathogens

Inflammatory signals directly instruct PU.1 in HSCs via TNF

(2018) Martin Etzrodt et al.   BLOOD

Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis

(2018) Zhigang Cai et al.   Cell Stem Cell

Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation

(2018) Zhiyang Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age

(2018) Mati Mann et al.   Cell Reports

Autophagy maintains the metabolism and function of young and old stem cells

(2017) Theodore T. Ho et al.   NATURE

Granulocyte-derived TNFα promotes vascular and hematopoietic regeneration in the bone marrow

(2017) Emily Bowers et al.   NATURE MEDICINE

The Regulatory Role of IFN-γ on the Proliferation and Differentiation of Hematopoietic Stem and Progenitor Cells

(2017) Yuhong Qin et al.   Stem Cell Reviews and Reports

The Regulatory Role of IFN-γ on the Proliferation and Differentiation of Hematopoietic Stem and Progenitor Cells

(2017) Yuhong Qin et al.   Stem Cell Reviews and Reports

IFNα-mediated remodeling of endothelial cells in the bone marrow niche

(2016) Áine M. Prendergast et al.   HAEMATOLOGICA

Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases

(2016) Mübeccel Akdis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TGF-α and IL-6 plasma levels selectively identify CML patients who fail to achieve an early molecular response or progress in the first year of therapy

(2016) E Nievergall et al.   LEUKEMIA

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

(2016) Eric M. Pietras et al.   NATURE CELL BIOLOGY

CXCR4/CXCL12 axis counteracts hematopoietic stem cell exhaustion through selective protection against oxidative stress

(2016) Yanyan Zhang et al.   Scientific Reports

Promotion of Expansion and Differentiation of Hematopoietic Stem Cells by Interleukin-27 into Myeloid Progenitors to Control Infection in Emergency Myelopoiesis

(2016) Jun-ichi Furusawa et al.   PLoS Pathogens

IFNα-mediated remodeling of endothelial cells in the bone marrow niche

(2016) Áine M. Prendergast et al.   HAEMATOLOGICA

Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the Bone Marrow Microenvironment

(2016) Larisa V. Kovtonyuk et al.   Frontiers in Immunology

Stress and Non-Stress Roles of Inflammatory Signals during HSC Emergence and Maintenance

(2016) Thomas Clapes et al.   Frontiers in Immunology

Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors

(2015) Simon Haas et al.   Cell Stem Cell

The inflammatory microenvironment in MDS

(2015) Lili Yang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes

(2015) I Gañán-Gómez et al.   LEUKEMIA

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

(2015) Dagmar Walter et al.   NATURE

Posttranscriptional regulation of c-Myc expression in adult murine HSCs during homeostasis and interferon- -induced stress response

(2014) A. Ehninger et al.   BLOOD

Inflammatory signaling regulates hematopoietic stem and progenitor cell emergence in vertebrates

(2014) Q. He et al.   BLOOD

Impact of interferon-  on hematopoiesis

(2014) A. M. de Bruin et al.   BLOOD

Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis

(2014) S. Boettcher et al.   BLOOD

Proinflammatory Signaling Regulates Hematopoietic Stem Cell Emergence

(2014) Raquel Espín-Palazón et al.   CELL

Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle

(2014) Isabel Beerman et al.   Cell Stem Cell

Cytotoxic CD8+ T Cells Stimulate Hematopoietic Progenitors by Promoting Cytokine Release from Bone Marrow Mesenchymal Stromal Cells

(2014) Christian M. Schürch et al.   Cell Stem Cell

Conversion of Danger Signals into Cytokine Signals by Hematopoietic Stem and Progenitor Cells for Regulation of Stress-Induced Hematopoiesis

(2014) Jimmy L. Zhao et al.   Cell Stem Cell

Interferon Gamma Signaling Positively Regulates Hematopoietic Stem Cell Emergence

(2014) Suphansa Sawamiphak et al.   DEVELOPMENTAL CELL

Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production

(2014) Yan Li et al.   GENES & DEVELOPMENT

Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons

(2014) Eric M. Pietras et al.   JOURNAL OF EXPERIMENTAL MEDICINE

G-CSF regulates hematopoietic stem cell activity, in part, through activation of Toll-like receptor signaling

(2014) L G Schuettpelz et al.   LEUKEMIA

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

(2014) Johanna Flach et al.   NATURE

Hematopoietic stem cell niche maintenance during homeostasis and regeneration

(2014) Avital Mendelson et al.   NATURE MEDICINE

Sympathetic Neural Regulation of Blood Pressure: Influences of Sex and Aging

(2014) E. C. J. Hart et al.   PHYSIOLOGY

Embryonic hematopoiesis

(2013) Rachel Golub et al.   BLOOD CELLS MOLECULES AND DISEASES

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Mechanisms that Regulate Stem Cell Aging and Life Span

(2013) Robert A.J. Signer et al.   Cell Stem Cell

Hematopoiesis

(2013) M. Jagannathan-Bogdan et al.   DEVELOPMENT

Increased Fanconi C expression contributes to the emergency granulopoiesis response

(2013) Liping Hu et al.   JOURNAL OF CLINICAL INVESTIGATION

Toll-like receptor alterations in myelodysplastic syndrome

(2013) Y Wei et al.   LEUKEMIA

Regulation of Hematopoietic Stem Cell Activity by Inflammation

(2013) Laura G. Schuettpelz et al.   Frontiers in Immunology

Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing

(2012) A. V. Ergen et al.   BLOOD

Cutting Edge: LPS-Induced Emergency Myelopoiesis Depends on TLR4-Expressing Nonhematopoietic Cells

(2012) S. Boettcher et al.   JOURNAL OF IMMUNOLOGY

Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling

(2011) K. Y. King et al.   BLOOD

Tumor necrosis factor receptor cross-talk

(2011) Petrus J. W. Naudé et al.   FEBS Journal

Inflammation, the microenvironment and chronic lymphocytic leukemia

(2011) F. Caligaris-Cappio   HAEMATOLOGICA

Cell cycle regulation in hematopoietic stem cells

(2011) Eric M. Pietras et al.   JOURNAL OF CELL BIOLOGY

Circulating Interleukin (IL)-8, IL-2R, IL-12, and IL-15 Levels Are Independently Prognostic in Primary Myelofibrosis: A Comprehensive Cytokine Profiling Study

(2011) Ayalew Tefferi et al.   JOURNAL OF CLINICAL ONCOLOGY

Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors

(2011) Cornelis J.H. Pronk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells

(2011) Brad Dykstra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Loss of Cxcl12/Sdf-1 in adult mice decreases the quiescent state of hematopoietic stem/progenitor cells and alters the pattern of hematopoietic regeneration after myelosuppression

(2010) Y.-S. Tzeng et al.   BLOOD

Expression of Toll-like receptor 9 in bone marrow cells of myelodysplastic syndromes is down-regulated during transformation to overt leukemia

(2010) Nobuo Kuninaka et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Infection-Induced Myelopoiesis during Intracellular Bacterial Infection Is Critically Dependent upon IFN-  Signaling

(2010) K. C. MacNamara et al.   JOURNAL OF IMMUNOLOGY

Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection

(2010) Megan T. Baldridge et al.   NATURE

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

(2010) I. Beerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IFNα activates dormant haematopoietic stem cells in vivo

(2009) Marieke A. G. Essers et al.   NATURE

Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

(2008) Stuart H. Orkin et al.   CELL

Of lineage and legacy: the development of mammalian hematopoietic stem cells

(2008) Elaine Dzierzak et al.   NATURE IMMUNOLOGY

ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling

(2008) Jochen C Hartner et al.   NATURE IMMUNOLOGY