Xanthohumol Impairs the PMA-Driven Invasive Behaviour of Lung Cancer Cell Line A549 and Exerts Anti-EMT Action

Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice

(2020) Amit S. Choudhari et al.   Frontiers in Pharmacology

Xanthohumol targets the ERK1/2‑Fra1 signaling axis to reduce cyclin D1 expression and inhibit non‑small cell lung cancer

(2020) Feng Gao et al.   ONCOLOGY REPORTS

The Multiple Biological Targets of Hops and Bioactive Compounds

(2019) Judy L. Bolton et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Xanthohumol exhibits anti-myeloma activity in vitro through inhibition of cell proliferation, induction of apoptosis via the ERK and JNK-dependent mechanism, and suppression of sIL-6R and VEGF production

(2019) Adrianna Sławińska-Brych et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Anticancer Activity and Mechanism of Xanthohumol: A Prenylated Flavonoid From Hops (Humulus lupulus L.)

(2018) Chuan-Hao Jiang et al.   Frontiers in Pharmacology

N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer

(2018) Krzysztof Marek Mrozik et al.   BMC CANCER

Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods

(2018) J. Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

PKCζ, MMP-2 and MMP-9 expression in lung adenocarcinoma and association with a metastatic phenotype

(2017) Xiaoshan Cai et al.   Molecular Medicine Reports

Daurinol blocks breast and lung cancer metastasis and development by inhibition of focal adhesion kinase (FAK)

(2017) Jong Kyu Woo et al.   Oncotarget

Incidence and mortality of lung cancer: global trends and association with socioeconomic status

(2017) Martin C. S. Wong et al.   Scientific Reports

Lung Cancer: Understanding Its Molecular Pathology and the 2015 WHO Classification

(2017) Kentaro Inamura   Frontiers in Oncology

The miR-204-3p-targeted IGFBP2 pathway is involved in xanthohumol-induced glioma cell apoptotic death

(2016) Peng-Hsu Chen et al.   NEUROPHARMACOLOGY

The ERK–ZEB1 pathway mediates epithelial–mesenchymal transition in pemetrexed resistant lung cancer cells with suppression by vinca alkaloids

(2016) L-Y Chiu et al.   ONCOGENE

The biological role of epithelial-mesenchymal transition in lung cancer (Review)

(2016) Woo Jung Sung et al.   ONCOLOGY REPORTS

Xanthohumol inhibits the extracellular signal regulated kinase (ERK) signalling pathway and suppresses cell growth of lung adenocarcinoma cells

(2016) Adrianna Sławińska-Brych et al.   TOXICOLOGY

Mechanisms of TGFβ-Induced Epithelial–Mesenchymal Transition

(2016) Aristidis Moustakas et al.   Journal of Clinical Medicine

Xanthohumol inhibits cell cycle progression and proliferation of larynx cancer cells in vitro

(2015) Adrianna Sławińska-Brych et al.   CHEMICO-BIOLOGICAL INTERACTIONS

TGF-β-activated SMAD3/4 complex transcriptionally upregulates N-cadherin expression in non-small cell lung cancer

(2015) Haiping Yang et al.   LUNG CANCER

Suppression of A549 cell proliferation and metastasis by calycosin via inhibition of the PKC-α/ERK1/2 pathway: An in vitro investigation

(2015) XU-DONG CHENG et al.   Molecular Medicine Reports

Xanthohumol Inhibits Notch Signaling and Induces Apoptosis in Hepatocellular Carcinoma

(2015) Selvi Kunnimalaiyaan et al.   PLoS One

Snail regulates Nanog status during the epithelial–mesenchymal transition via the Smad1/Akt/GSK3β signaling pathway in non-small-cell lung cancer

(2015) Chen-Wei Liu et al.   Oncotarget

α-catenin

(2014) Yutong Sun et al.   CELL CYCLE

Xanthohumol suppresses oestrogen-signalling in breast cancer through the inhibition of BIG3-PHB2 interactions

(2014) Tetsuro Yoshimaru et al.   Scientific Reports

Gelatinase B/MMP-9 in Tumour Pathogenesis and Progression

(2014) Antonietta Farina et al.   Cancers

Xanthohumol attenuates tumour cell-mediated breaching of the lymphendothelial barrier and prevents intravasation and metastasis

(2013) Katharina Viola et al.   ARCHIVES OF TOXICOLOGY

2-Hydroxychalcone and xanthohumol inhibit invasion of triple negative breast cancer cells

(2013) Sun Young Kim et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Chemoprevention of Lung Cancer

(2013) Eva Szabo et al.   CHEST

Unknown

(2013) Roberta Vene et al.   MOLECULAR MEDICINE

The AKT/NF-κB inhibitor xanthohumol is a potent anti-lymphocytic leukemia drug overcoming chemoresistance and cell infiltration

(2012) Roberto Benelli et al.   BIOCHEMICAL PHARMACOLOGY

Genetic polymorphisms in MMP 2, 9 and 3genes modify lung cancer risk and survival

(2012) Patricia González-Arriaga et al.   BMC CANCER

TGF-β – an excellent servant but a bad master

(2012) Lenka Kubiczkova et al.   Journal of Translational Medicine

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Novel Therapeutic Targets in Non-small Cell Lung Cancer

(2011) Filip Janku et al.   Journal of Thoracic Oncology

Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines

(2011) João R. Araújo et al.   NUTRITION RESEARCH

Cancer metastasis as a therapeutic target

(2010) Jonathan Sleeman et al.   EUROPEAN JOURNAL OF CANCER

Phorbol ester phorbol-12-myristate-13-acetate induces epithelial to mesenchymal transition in human prostate cancer ARCaPE cells

(2010) Hui He et al.   PROSTATE

Anti-Invasive and Anti-Angiogenic Effects of Xanthohumol and Its Synthetic Derivatives

(2009) Jung-Ae Kim et al.   Biomolecules & Therapeutics

Plumbagin inhibits TPA-induced MMP-2 and u-PA expressions by reducing binding activities of NF-κB and AP-1 via ERK signaling pathway in A549 human lung cancer cells

(2009) Jiunn-Min Shieh et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

In vitro evaluation of antibacterial, anticollagenase, and antioxidant activities of hop components (Humulus lupulus) addressing acne vulgaris

(2009) Naoto Yamaguchi et al.   PHYTOMEDICINE

Xanthohumol inhibits inflammatory factor production and angiogenesis in breast cancer xenografts

(2008) Rosário Monteiro et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Transforming growth factor-β1 increases cell migration and β1 integrin up-regulation in human lung cancer cells

(2008) Yi-Chin Fong et al.   LUNG CANCER

Antileukemia effects of xanthohumol in Bcr/Abl-transformed cells involve nuclear factor- B and p53 modulation

(2008) S. Monteghirfo et al.   MOLECULAR CANCER THERAPEUTICS