The ERK–ZEB1 pathway mediates epithelial–mesenchymal transition in pemetrexed resistant lung cancer cells with suppression by vinca alkaloids

FRA-1 as a driver of tumour heterogeneity: a nexus between oncogenes and embryonic signalling pathways in cancer

(2014) A S Dhillon et al.   ONCOGENE

Expression of thymidylate synthase predicts clinical outcomes of pemetrexed-containing chemotherapy for non-small-cell lung cancer: a systemic review and meta-analysis

(2013) Yu Liu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Vinorelbine in pemetrexed-pretreated patients with malignant pleural mesothelioma

(2013) P.A. Zucali et al.   LUNG CANCER

Thymidylate Synthase Expression Determines Pemetrexed Targets and Resistance Development in Tumour Cells

(2013) Aitziber Buqué et al.   PLoS One

Establishment of pemetrexed-resistant non-small cell lung cancer cell lines

(2011) Dan Zhang et al.   CANCER LETTERS

Sustained activation of ERK and Cdk2/cyclin-A signaling pathway by pemetrexed leading to S-phase arrest and apoptosis in human non-small cell lung cancer A549 cells

(2011) Tsung-Ying Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Thymidylate synthase and dihydrofolate reductase expression in non-small cell lung carcinoma: The association with treatment efficacy of pemetrexed

(2011) Chung-Yu Chen et al.   LUNG CANCER

Pemetrexed induces both intrinsic and extrinsic apoptosis through ataxia telangiectasia mutated/p53-dependent and -independent signaling pathways

(2011) Tsung-Ying Yang et al.   MOLECULAR CARCINOGENESIS

Targeting miRNAs involved in cancer stem cell and EMT regulation: An emerging concept in overcoming drug resistance

(2010) Zhiwei Wang et al.   DRUG RESISTANCE UPDATES

The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition

(2010) David S Yee et al.   Molecular Cancer

ERK2 but Not ERK1 Induces Epithelial-to-Mesenchymal Transformation via DEF Motif-Dependent Signaling Events

(2010) Sejeong Shin et al.   MOLECULAR CELL

ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1

(2010) E Sánchez-Tilló et al.   ONCOGENE

Acquisition of Epithelial-Mesenchymal Transition Phenotype of Gemcitabine-Resistant Pancreatic Cancer Cells Is Linked with Activation of the Notch Signaling Pathway

(2009) Z. Wang et al.   CANCER RESEARCH

Significance of thymidylate synthase for resistance to pemetrexed in lung cancer

(2009) Hiroaki Ozasa et al.   CANCER SCIENCE

L-type calcium channel blockers reverse docetaxel and vincristine-induced multidrug resistance independent of ABCB1 expression in human lung cancer cell lines

(2009) Ling-Yen Chiu et al.   TOXICOLOGY LETTERS

Epithelial to mesenchymal transition derived from repeated exposure to gefitinib determines the sensitivity to EGFR inhibitors in A549, a non-small cell lung cancer cell line

(2008) Jin Kyung Rho et al.   LUNG CANCER

Taxanes, microtubules and chemoresistant breast cancer

(2007) Barbara T. McGrogan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER