Article
Medicine, Research & Experimental
Chengwei Wu, Xianghai Wang, Xingwei Wu, Xingwu Chen
Summary: ENC1 is highly expressed in lung cancer tissues and cells compared to para-cancerous tissues and non-cancer lung cells. Knockdown of ENC1 with si-ENC1 significantly reduced proliferation, migration, and invasion of A549 and H1299 cells. Downregulation of ENC1 resulted in decreased levels of MMP2, MMP9, N-cadherin, p-JNK, p-ERK, and p-p38, while upregulating E-cadherin. In a mouse lung tumor model, reduced levels of ENC1 inhibited tumor growth. This suggests that ENC1 plays a role in the progression of lung cancer and may be a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Xiaoli Pan, Junping Pei, Aoxue Wang, Wen Shuai, Lu Feng, Faqian Bu, Yumeng Zhu, Lan Zhang, Guan Wang, Liang Ouyang
Summary: This review provides an overview of the roles of the ERKs signaling pathway in cancer and the structure-activity relationships of small molecule inhibitors targeting ERKs. It offers important insights for drug design and optimization as well as potential therapeutic strategies to overcome drug resistance.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Oncology
Jie Lang, Zhizhen Guo, Shushan Xing, Jian Sun, Bin Qiu, Yu Shu, Zhiqiang Wang, Guixiang Liu
Summary: This study investigated the effect and mechanism of puerarin on the invasion and metastasis of A549 lung cancer cell line. The results showed that puerarin could inhibit cell migration and reduce the expression of invasion and metastasis-related factor MMP9. Furthermore, puerarin could also inhibit the phosphorylation of ERK.
TRANSLATIONAL CANCER RESEARCH
(2022)
Article
Oncology
Eun Ju Kim, Jeong Seon Kim, Sieun Lee, Inyoung Cheon, Seo Ree Kim, Yoon Ho Ko, Keunsoo Kang, Xiaochao Tan, Jonathan M. Kurie, Young-Ho Ahn
Summary: The study found that lnc-Nr2f1 is upregulated by ZEB1 and NR2F1 in lung adenocarcinoma cells, and promotes migration and invasion of these cells by regulating TWIST2.
Article
Biochemistry & Molecular Biology
Joanna Szuszkiewicz, Kamil Myszczynski, Zaneta P. Reliszko, Yael Heifetz, Monika M. Kaczmarek
Summary: Research has shown that during early pregnancy, communication between the embryo and uterus occurs through the exchange of extracellular vesicles carrying miRNAs. These vesicles impact embryonic development and trophoblast cell function and interactions, playing a crucial role in successful embryo implantation and pregnancy.
Article
Nutrition & Dietetics
Yu-Chen Liu, Chun-Chao Chang, Hirofumi Matsui, Jane C. -J. Chao
Summary: This study found that C-phycocyanin (CPC) and Lycium barbarum polysaccharides (LBP) can protect against gastric damage caused by aspirin. They can reduce inflammation and decrease cell apoptosis to alleviate gastric mucosal injury. These findings suggest that CPC and LBP may be potential drugs for the treatment of gastric damage.
Article
Oncology
Onsurang Wattanathamsan, Paninee Chetprayoon, Naphat Chantaravisoot, Piriya Wongkongkathep, Pithi Chanvorachote, Varisa Pongrakhananon
Summary: This study demonstrates that CAMSAP3 plays an intriguing role in lung carcinoma cell senescence-associated phenotypes through modulating p-ERK/cyclin D1 signaling pathway. CAMSAP3 knockout promotes senescence and G1 cell cycle arrest in lung cancer cells by downregulating p-ERK and cyclin D1 levels. Vimentin appears to be required as a scaffold for CAMSAP3-modulating ERK signaling in lung cancer cells.
Article
Cell Biology
Chungen Lan, Huikun Zhang, Kezhen Wang, Xiaoli Liu, Yawen Zhao, Zhifang Guo, Ning Zhang, Yongxia Zhou, Manzhi Gao, Feng Gu, Yongjie Ma
Summary: The study demonstrates that PTBP1 modulates the alternative splicing of ITSN1, promoting glioma proliferation and motility by up-regulating the ratio of ITSN1-S/ITSN1-L, suggesting that PTBP1 may be a promising therapeutic target for gliomas.
CELL DEATH & DISEASE
(2022)
Article
Pharmacology & Pharmacy
Yan Hu, Zhe Zhao, Yuan-Ting Liu, Ze-Cheng Xu, Jing-Yi Li, Zheng-Yu Yang, Yun-Qi Yang, Jia-Hui Zhang, Si-Yuan Qiu, Tao He, Yi-Ying Wu, Sha Liu
Summary: This study found that NITyr inhibits non-small cell lung cancer (NSCLC) by activating CB1 and CB2 receptors, involving the PI3K and ERK pathways. It inhibits cell proliferation, blocks the cell cycle, induces apoptosis, and inhibits migration.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell & Tissue Engineering
Jie Zhou, Junying Yang, Yuan Dong, Yaru Shi, Endong Zhu, Hairui Yuan, Xiaoxia Li, Baoli Wang
Summary: Our study has for the first time established the direct role of OSMR in regulating osteogenic differentiation of marrow stromal progenitor cells through ERK-mediated autophagy signaling. OSMR thus contributes to bone homeostasis through dual regulation of osteoblasts and osteoclasts. It also suggests that OSMR may be a potential target for the treatment of metabolic disorders such as osteoporosis.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Psychology, Developmental
Craig A. Erickson, Charles R. Tessier, Christina Gross, Ernest Pedapati, Logan K. Wink, Kelli C. Dominick, Rebecca C. Shaffer, Hilary Rosselot, Michael P. Hong, Andrew P. Bantel, Elizabeth Berry-Kravis, Paul S. Horn, Ryan Adams, John A. Sweeney
Summary: This study investigated the activity of ERK1/2 in autism spectrum disorder (ASD). The results showed that lymphocytic ERK1/2 activation was faster in individuals with ASD, and this was correlated with greater social impairment. The differences in ERK1/2 activation were more pronounced in younger individuals.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Medicine, Research & Experimental
Jieun Jeon, Tamanna Jahan Mony, Eunbi Cho, Huiyoung Kwon, Wan-Seob Cho, Ji Woong Choi, Byeong C. Kim, Jong Hoon Ryu, Se Jin Jeon, Kyoung Ja Kwon, Chan Young Shin, Se Jin Park, Dong Hyun Kim
Summary: In this study, it was found that rubrofusarin enhances learning and memory in mice and promotes neurite outgrowth. These effects may be achieved through activation of the ERK pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Hidenori Kanno, Sei Naito, Yutaro Obara, Hiromi Ito, Osamu Ichiyanagi, Takafumi Narisawa, Tomoyuki Kato, Akira Nagaoka, Norihiko Tsuchiya
Summary: ERK5 has been found to be highly expressed in clear cell renal cell carcinoma (ccRCC) and is associated with high grade, high recurrence rate, and high cancer-specific survival. The expression of ERK5 is regulated by miR-143. Inhibition of ERK5 holds promise as a potential target for ccRCC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Cian Gavin, Nele Geerts, Brenton Cavanagh, Meagan Haynes, C. Patrick Reynolds, Daniela Loessner, Andrew J. Ewald, Olga Piskareva
Summary: Paediatric cancer research, especially in neuroblastoma, lacks preclinical models of metastasis. This study developed a patient-derived xenograft (PDX) and cell line-based organoid model to understand the molecular mechanisms of neuroblastoma metastasis. The ECM composition influenced the growth, viability, and invasion of organoids, with PDX-derived organoids showing various invasion phenotypes dependent on the microenvironment. Real-time imaging and 3D culture assays will help elucidate the molecular mechanisms controlling neuroblastoma invasion.
Review
Toxicology
Yujia Xie, Jixuan Ma, Meng Yang, Lieyang Fan, Weihong Chen
Summary: Silicosis is a scarring lung disease caused by inhaling fine particles of crystalline silica in the workplace. The underlying molecular mechanisms of silicosis are not fully understood, but recent studies have highlighted the role of the activated ERK signaling pathway in regulating oxidative stress, inflammatory response, fibroblast activation, and other processes involved in the formation and development of silicosis.
TOXICOLOGY RESEARCH
(2021)